Zinc-Deficient Rats Have Fewer Recent Thymic Emigrant (CD90+) T Lymphocytes in Spleen and Blood

Journal of Nutrition

Volumn 133, Issue 12, 2003, Pages 4239-4242

  Hosea, Heather J ^a   Rector, Edward S ^a   Taylor, Carla G ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

Author keywords

P56lck; Rats; Recent thymic emigrants; T lymphocytes; Zinc

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; T LYMPHOCYTE RECEPTOR; THY 1 ANTIGEN; ZINC;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIETARY INTAKE; MALNUTRITION; NONHUMAN; RAT; SPLEEN; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; THYMUS; WESTERN BLOTTING; ZINC DEFICIENCY;

ANIMALIA;

EID: 0344306493     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/133.12.4239     Document Type: Article

References (21)

1. lck. Nature (Lond.) 357: 161-164.
2. lck in thymopoiesis. EMBO J. 12: 1671-1680.
3. lck. J. Exp. Med. 173: 1421-4132.
4. lck, a zinc-finger signal transduction protein, is elevated by dietary zinc deficiency and diet restriction in mice. J. Nutr. 129: 620-627.
5. Moore, J. B., Blanchard, R. K., McCormack, W. T. & Cousins, R. J. (2001) cDNA array analysis identifies thymic LCK as upregulated in moderate murine zinc deficiency before T-lymphocyte population changes. J. Nutr. 131: 3189-3196.
6. Chandra, R. K. (1979) T and B lymphocyte subpopulations and leukocyte terminal deoxynucleotidyl-transferase in energy-protein undernutrition. Acta Paediatr. Scand. 68: 841-845.
7. Nash, L., Iwata, T., Fernandes, G., Good, R. A. & Incefy, G. S. (1979) Effect of zinc deficiency on autologous rosette-forming cells. Cell. Immunol. 48: 238-243.
8. Parent, G., Chevalier, P., Zalles, L., Sevilla, R., Bustos, M., Dhenin, J. & Jambon, B. (1994) In vitro lymphocyte-differentiating effects of thymulin (Zn-FTS) on lymphocyte subpopulations of severely malnourished children. Am. J. Clin. Nutr. 60: 274-278.
9. Bossuyt, P. J., Rector, E. S. & Taylor, C. G. (2001) Dietary zinc deficiency and protein-energy malnutrition decrease in vitro T lymphocyte cell cycle progression. J. Nutr. Immunol. 5: 71-83.
10. Bergeron, M., Faucher, S., Ding, T., Phaneuf, S. & Mandy, F. (2002) Evaluation of a universal template for single-platform absolute T-lymphocyte subset enumeration. Cytometry 50: 62-68.
11. Fujise, S., Matsuzaki, G., Kishihara, K., Kadena, T., Molina, T. & Nomoto, K. (1996) The role of p56lck in the development of γ δ T cells and their function during an infection by listeria monocytogenes. J. Immunol. 157: 247-254.
12. Hosseinzadeh, H. & Goldschneider, I. (1993) Recent thymic emigrants in the rat express a unique antigenic phenotype and undergo post-thymic maturation in peripheral lymphoid tissues. J. Immunol. 150: 1670-1679.
13. Iwakoshi, N. N., Goldschneider, I., Tausche, F., Mordes, J. P., Rossini, A. A. & Greiner, D. L. (1998) High frequency apoptosis of recent thymic emigrants in the liver of lymphopenic diabetes-prone BioBreeding rats. J. Immunol. 160: 5838-5850.
14. Kendall, M. D. (1991) Functional anatomy of the thymic microenvironment. J. Anat. 177: 1-29.
15. Di Somma, M., Nuti, S., Telford, J. L. & Baldari, T. (1995) p56lck plays a key role in transducing apoptotic signals in T cells. FEBS Lett. 363: 101-104.
16. Hunig, T., Torres-Nagel, N., Mehling, B., Park, H.-Y. & Herrmann, T. (2001) Thymic development and repertoire selection: the rat perspective. Immunol. Rev. 184: 7-19.
17. Woodward, B. (2003) Apoptotic loss of thymic lymphocytes in acute murine zinc deficiency [Letter]. J. Nutr. 133: 814.
18. Beck, F.W.J., Prasad, A. S., Kaplan, J., Fitzgerald, J. T. & Brewer, G. J. (1997) Changes in cytokine production and T cell subpopulations in experimentally induced zinc-deficient humans. Am. J. Physiol. 272: E1002-E1007.
19. Fraker, P. J., King, L. E., Laakko, T. & Vollmer, T. L. (2000) The dynamic link between the integrity of the immune system and zinc status. J. Nutr. 130: 1399S-1406S.
20. King, L. E., Osati-Ashtiani, F. & Fraker, P. J. (2002) Apoptosis plays a distinct role in the loss of precursor lymphocytes during zinc deficiency in mice. J. Nutr. 132: 974-979.
21. Slobodianik, N. H., Cosarinsky, R. C., Langini, S. H., Roux, M. E., Rio, M. E. & Sanahuja, J. C. (1984) Effect of severe protein deficiency on surface and intracellular markers of growing rats' lymphoid organs. Nutr. Rep. Int. 29: 957-964.