Pseudechetoxin Binds to the Pore Turret of Cyclic Nucleotide-gated Ion Channels

Journal of General Physiology

Volumn 122, Issue 6, 2003, Pages 749-760

  Brown, R Lane ^a   Lynch, Leatha L ^a   Haley, Tammie L ^a   Arsanjani, Reza ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

CNG channel; Neurotoxin; Patch clamp electrophysiology; Snake venom; Xenopus oocyte

Indexed keywords

CYCLIC NUCLEOTIDE; ION CHANNEL; NEUROTOXIN; PEPTIDE TOXIN; PROTEIN SUBUNIT; PSEUDECHETOXIN; SNAKE VENOM; THIOMESYLIC ACID METHYL ESTER; TOXIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CHANNEL GATING; CHIMERA; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ELECTRICITY; ELECTROPHYSIOLOGY; EMBRYO; EXTRACELLULAR SPACE; HUMAN; HUMAN CELL; NONHUMAN; PATCH CLAMP; PHOTORECEPTOR CELL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN STRUCTURE; RETINA CONE; SIGNAL TRANSDUCTION; XENOPUS;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELAPID VENOMS; HUMANS; ION CHANNEL GATING; ION CHANNELS; MOLECULAR SEQUENCE DATA; SNAKE VENOMS;

EID: 0344304501     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.200308823     Document Type: Article

References (51)

1. Biel, M., X. Zong, M. Distler, E. Bosse, N. Klugbauer, M. Murakami, V. Flockerzi, and F. Hofmann. 1994. Another member of the cyclic nucleotide-gated channel family, expressed in testis, kidney, and heart. Proc. Natl. Acad. Sci. USA. 91:3505-3509.
2. Bonigk, W., J. Bradley, F. Muller, F. Sesti, I. Boekhoff, G.V. Ronnett, U.B. Kaupp, and S. Frings. 1999. The native rat olfactory cyclic nucleotide-gated channel is composed of three distinct subunits. J. Neurosci. 19:5332-5347.
3. Bontems, F., C. Roumestand, B. Gilquin, A. Menez, and F. Toma. 1991. Refined structure of charybdotoxin: common motifs in scorpion toxins and insect defensins. Science. 254:1521-1523.
4. Bourinet, E., T.W. Soong, K. Sutton, S. Slaymaker, E. Mathews, A. Monteil, G.W. Zamponi, J. Nargeot, and T.P. Snutch. 1999. Splicing of alpha 1A subunit gene generates phenotypic variants of P- and Q-type calcium channels. Nat. Neurosci. 2:407-415.
5. Bradley, J., S. Frings, K.W. Yau, and R. Reed. 2001. Nomenclature for ion channel subunits. Science. 294:2095-2096.
6. Bradley, J., J. Li, N. Davidson, H.A. Lester, and K. Zinn. 1994. Heteromeric olfactory cyclic nucleotide-gated channels: a subunit that confers increased sensitivity to cAMP. Proc. Natl. Acad. Sci. USA. 91:8890-8894.
7. Brown, R.L., S.D. Snow, and T.L. Haley. 1998. Movement of gating machinery during the activation of rod cyclic nucleotide-gated channels. Biophys. J. 75:825-833.
8. Brown, R.L., T.L. Haley, K.A. West, and J.W. Crabb. 1999. Pseudechetoxin: a peptide blocker of cyclic nucleotide-gated ion channels. Proc. Natl. Acad. Sci. USA. 96:754-759.
9. Chen, T.Y., Y.W. Peng, R.S. Dhallan, B. Ahamed, R.R. Reed, and K.W. Yau. 1993. A new subunit of the cyclic nucleotide-gated cation channel in retinal rods. Nature. 362:764-767.
10. Dhallan, R.S., K.W. Yau, K.A. Schrader, and R.R. Reed. 1990. Primary structure and functional expression of a cyclic nucleotide-activated channel from olfactory neurons. Nature. 347:184-187.
11. Doyle, D.A., C.J. Morais, R.A. Pfuetzner, A. Kuo, J.M. Gulbis, S.L. Cohen, B.T. Chait, and R. MacKinnon. 1998. The structure of the potassium channel: molecular basis of K+ conduction and selectivity. Science. 280:69-77.
12. Ellinor, P.T., J.F. Zhang, W.A. Horne, and R.W. Tsien. 1994. Structural determinants of the blockade of N-type calcium channels by a peptide neurotoxin. Nature. 372:272-275.
13. Feng, Z.P., J. Hamid, G.M. Bosey, T.P. Snutch, and G.W. Zamponi. 2001. Residue Gly1326 of the N-type calcium channel alpha 1B subunit controls reversibility of omega-conotoxin GVIA and MVIIA block. J. Biol. Chem. 276:15728-15735.
14. Finn, J.T., M.E. Grunwald, and K.W. Yau. 1996. Cyclic nucleotide-gated ion channels: an extended family with diverse functions. Annu. Rev. Physiol. 58:395-426.
15. Garcia, M.L., Y. Gao, O.B. McManus, and G.J. Kaczorowski. 2001. Potassium channels: from scorpion venoms to high-resolution structure. Toxicon. 39:739-748.
16. Garcia, M.L., M. Garcia-Calvo, P. Hidalgo, A. Lee, and R. MacKinnon. 1994. Purification and characterization of three inhibitors of voltage-dependent K+ channels from Leiurus quinquestriatus var. hebraeus venom. Biochemistry. 33:6834-6839.
17. Gerstner, A., X. Zong, F. Hofmann, and M. Biel. 2000. Molecular cloning and functional characterization of a new modulatory cyclic nucleotide-gated channel subunit from mouse retina. J. Neurosci. 20:1324-1332.
18. Gross, A., T. Abramson, and R. MacKinnon. 1994. Transfer of the scorpion toxin receptor to an insensitive potassium channel. Neuron. 13:961-966.
19. Gross, A., and R. MacKinnon. 1996. Agitoxin footprinting the shaker potassium channel pore. Neuron. 16:399-406.
20. Harvey, A.L. 2001. Twenty years of dendrotoxins. Toxicon. 39:15-26.
21. Heginbotham, L., T. Abramson, and R. MacKinnon. 1992. A functional connection between the pores of distantly related ion channels as revealed by mutant K+ channels. Science. 258:1152-1155.
22. Hidalgo, P., and R. MacKinnon. 1995. Revealing the architecture of a K+ channel pore through mutant cycles with a peptide inhibitor. Science. 268:307-310.
23. Kaupp, U.B., T. Niidome, T. Tanabe, S. Terada, W. Bonigk, W. Stuhmer, N.J. Cook, K. Kangawa, H. Matsuo, T. Hirose, et al. 1989. Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel. Nature. 342:762-766.
24. Kaupp, U.B., and R. Seifert. 2002. Cyclic nucleotide-gated ion channels. Physiol. Rev. 82:769-824.
25. Korschen, H.G., M. Illing, R. Seifert, F. Sesti, A. Williams, S. Gotzes, C. Colville, F. Muller, A. Dose, M. Godde, et al. 1995. A 240 kDa protein represents the complete beta subunit of the cyclic nucleotide-gated channel from rod photoreceptor. Neuron. 15:627-636.
26. Krezel, A.M., C. Kasibhatla, P. Hidalgo, R. MacKinnon, and G. Wagner. 1995. Solution structure of the potassium channel inhibitor agitoxin 2: caliper for probing channel geometry. Protein Sci. 4:1478-1489.
27. Lampe, R.A., P.A. DeFeo, M.D. Davison, J. Young, J.L. Herman, R.C. Spreen, M.B. Horn, T.J. Mangano, and R.A. Keith. 1993. Isolation and pharmacological characterization of omega-grammotoxin SIA, a novel peptide inhibitor of neuronal voltage-sensitive calcium channel responses. Mol. Pharmacol. 44:451-460.
28. + channel determined by construction of multimeric cDNAs. Neuron. 9(5):861-871.
29. Liman, E.R., and L.B. Buck. 1994. A second subunit of the olfactory cyclic nucleotide-gated channel confers high sensitivity to cAMP. Neuron. 13:611-621.
30. Liu, J., and S.A. Siegelbaum. 2000. Change of pore helix conformational state upon opening of cyclic nucleotide-gated channels. Neuron. 28:899-909.
31. + channel. J. Gen. Physiol. 91:335-349.
32. MacKinnon, R., and C. Miller. 1989. Mutant potassium channels with altered binding of charybdotoxin, a pore-blocking peptide inhibitor. Science. 245:1382-1385.
33. MacKinnon, R., L. Heginbotham, and T. Abramson. 1990. Mapping the receptor site for charybdotoxin, a pore-blocking potassium channel inhibitor. Neuron. 5:767-771.
34. Mintz, I.M., V.J. Venema, K.M. Swiderek, T.D. Lee, B.P. Bean, and M.E. Adams. 1992. P-type calcium channels blocked by the spider toxin omega-Aga-IVA. Nature. 355:827-829.
35. Olivera, B.M., D.R. Hillyard, M. Marsh, and D. Yoshikami. 1995. Combinatorial peptide libraries in drug design: lessons from venomous cone snails. Trends Biotechnol. 13:422-426.
36. Olivera, B.M., J. Rivier, J.K. Scott, D.R. Hillyard, and L.J. Cruz. 1991. Conotoxins. J. Biol. Chem. 266:22067-22070.
37. Pardo-Lopez, L., M. Zhang, J. Liu, M. Jiang, G.N. Tseng. 2002. Mapping the bidning site of a human ether-a-go-go-related gene-specific toxin (ErgTx) to the channel's outer vestibule. J. Biol. Chem. 277:16403-16411.
38. Ranganathan, R., J.H. Lewis, and R. MacKinnon. 1996. Spatial localization of the K+ channel selectivity filter by mutant cycle-based structure analysis. Neuron. 16:131-139.
39. Rash, L.D., and W.C. Hodgson. 2002. Pharmacology and biochemistry of spider venoms. Toxicon. 40:225-254.
40. Rho, S., H.M. Lee, K. Lee, and C. Park. 2000. Effects of mutation at a conserved N-glycosylation site in the bovine retinal cyclic nucleotide-gated ion channel. FEBS Lett. 478:246-252.
41. Rich, T.C., T.E. Tse, J.G. Rohan, J. Schaack, and J.W. Karpen. 2001. In vivo assessment of local phosphodiesterase activity using tailored cyclic nucleotide-gated channels as cAMP sensors. J. Gen. Physiol. 118:63-78.
42. Sautter, A., X. Zong, F. Hofmann, and M. Biel. 1998. An isoform of the rod photoreceptor cyclic nucleotide-gated channel beta subunit expressed in olfactory neurons. Proc. Natl. Acad. Sci. USA. 95:4696-4701.
43. Swartz, K.J., and R. MacKinnon. 1995. An inhibitor of the Kv2.1 potassium channel isolated from the venom of a Chilean tarantula. Neuron. 15:941-949.
44. Swartz, K.J., and R. MacKinnon. 1997. Mapping the receptor site for hanatoxin, a gating modifier of voltage-dependent K+ channels. Neuron. 18:675-682.
45. Weitz, D., N. Ficek, E. Kremmer, P.J. Bauer, and U.B. Kaupp. 2002. Subunit Stoichiometry of the CNG channel of rod photoreceptors. Neuron. 36:881-889.
46. Weyand, I., M. Godde, S. Frings, J. Weiner, F. Muller, W. Altenhofen, H. Hatt, and U.B. Kaupp. 1994. Cloning and functional expression of a cyclic-nucleotide-gated channel from mammalian sperm. Nature. 368:859-863.
47. Winterfield, J.R., and K.J. Swartz. 2000. A hot spot for the interaction of gating modifier toxins with voltage-dependent ion channels. J. Gen. Physiol. 116:637-644.
48. Yamazaki, Y., R.L. Brown, and T. Morita. 2002. Purification and cloning of toxins from elapid venoms that target cyclic nucleotide-gated ion channels. Biochemistry. 41:11331-11337.
49. + channel. Science. 251:939-942.
50. Zheng, J., M.C. Trudeau, and W.N. Zagotta. 2002. Rod cyclic nucleotide-gated channels have a stoichiometry of three CNGA1 subunits and one CNGB1 subunit. Neuron. 36:891-896.
51. Zhong, H., L.L. Molday, R.S. Molday, and K.W. Yau. 2002. The heteromeric cyclic nucleotide-gated channel adopts a 3A:1B stoichiometry. Nature. 420:193-198.