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Volumn 5, Issue 15, 2003, Pages 1345-1356

Helicobacter pylori flagellins have very low intrinsic activity to stimulate human gastric epithelial cells via TLR5

Author keywords

Flagellin; Gastric epithelial cells; Helicobacter pylori; TOLL like receptor 5

Indexed keywords

BACTERIAL PROTEIN; FLAGELLIN; INTERLEUKIN 8; TOLL LIKE RECEPTOR 5;

EID: 0344234277     PISSN: 12864579     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.micinf.2003.09.018     Document Type: Article
Times cited : (164)

References (58)
  • 1
    • 0037057683 scopus 로고    scopus 로고
    • Helicobacter pylori infection
    • Suerbaum S., Michetti P. Helicobacter pylori infection. N. Engl. J. Med. 347:2002;1175-1186.
    • (2002) N. Engl. J. Med. , vol.347 , pp. 1175-1186
    • Suerbaum, S.1    Michetti, P.2
  • 4
    • 0026570302 scopus 로고
    • Surface proteins from Helicobacter pylori exhibit chemotactic activity for human leukocytes and are present in gastric mucosa
    • Mai U.E., Perez-Perez G.I., Allen J.B., Wahl S.M., Blaser M.J., Smith P.D. Surface proteins from Helicobacter pylori exhibit chemotactic activity for human leukocytes and are present in gastric mucosa. J. Exp. Med. 175:1992;517-525.
    • (1992) J. Exp. Med. , vol.175 , pp. 517-525
    • Mai, U.E.1    Perez-Perez, G.I.2    Allen, J.B.3    Wahl, S.M.4    Blaser, M.J.5    Smith, P.D.6
  • 6
    • 0030860384 scopus 로고    scopus 로고
    • Mucosal chemokines in Helicobacter pylori infection
    • Shimoyama T., Crabtree J.E. Mucosal chemokines in Helicobacter pylori infection. J. Physiol. Pharmacol. 48:1997;315-323.
    • (1997) J. Physiol. Pharmacol. , vol.48 , pp. 315-323
    • Shimoyama, T.1    Crabtree, J.E.2
  • 8
    • 0029880538 scopus 로고    scopus 로고
    • Immune and inflammatory responses to Helicobacter pylori infection
    • Crabtree J.E. Immune and inflammatory responses to Helicobacter pylori infection. Scand. J. Gastroenterol. 215:(Suppl):1996;3-10.
    • (1996) Scand. J. Gastroenterol. , vol.215 , Issue.SUPPL , pp. 3-10
    • Crabtree, J.E.1
  • 9
    • 0031724633 scopus 로고    scopus 로고
    • Chemokine mRNA expression in gastric mucosa is associated with Helicobacter pylori cagA positivity and severity of gastritis
    • Shimoyama T., Everett S.M., Dixon M.F., Axon A.T., Crabtree J.E. Chemokine mRNA expression in gastric mucosa is associated with Helicobacter pylori cagA positivity and severity of gastritis. J. Clin. Pathol. 51:1998;765-770.
    • (1998) J. Clin. Pathol. , vol.51 , pp. 765-770
    • Shimoyama, T.1    Everett, S.M.2    Dixon, M.F.3    Axon, A.T.4    Crabtree, J.E.5
  • 11
    • 0032769215 scopus 로고    scopus 로고
    • Multiple genes in the left half of the cag pathogenicity island of Helicobacter pylori are required for tyrosine kinase-dependent transcription of interleukin-8 in gastric epithelial cells
    • Li S.D., Kersulyte D., Lindley I.J., Neelam B., Berg D.E., Crabtree J.E. Multiple genes in the left half of the cag pathogenicity island of Helicobacter pylori are required for tyrosine kinase-dependent transcription of interleukin-8 in gastric epithelial cells. Infect. Immun. 67:1999;3893-3899.
    • (1999) Infect. Immun. , vol.67 , pp. 3893-3899
    • Li, S.D.1    Kersulyte, D.2    Lindley, I.J.3    Neelam, B.4    Berg, D.E.5    Crabtree, J.E.6
  • 12
    • 0035725211 scopus 로고    scopus 로고
    • Systematic mutagenesis of the Helicobacter pylori cag pathogenicity island: Essential genes for CagA translocation in host cells and induction of interleukin-8
    • Fischer W., Püls J., Buhrdorf R., Gebert B., Odenbreit S., Haas R. Systematic mutagenesis of the Helicobacter pylori cag pathogenicity island: essential genes for CagA translocation in host cells and induction of interleukin-8. Mol. Microbiol. 42:2001;1337-1348.
    • (2001) Mol. Microbiol. , vol.42 , pp. 1337-1348
    • Fischer, W.1    Püls, J.2    Buhrdorf, R.3    Gebert, B.4    Odenbreit, S.5    Haas, R.6
  • 13
    • 0036156209 scopus 로고    scopus 로고
    • Functional analysis of the Helicobacter pylori cag pathogenicity island reveals both VirD4-CagA-dependent and VirD4-CagA-independent mechanisms
    • Selbach M., Moese S., Meyer T.F., Backert S. Functional analysis of the Helicobacter pylori cag pathogenicity island reveals both VirD4-CagA-dependent and VirD4-CagA-independent mechanisms. Infect. Immun. 70:2002;665-671.
    • (2002) Infect. Immun. , vol.70 , pp. 665-671
    • Selbach, M.1    Moese, S.2    Meyer, T.F.3    Backert, S.4
  • 14
    • 0031025291 scopus 로고    scopus 로고
    • Helicobacter pylori lipopolysaccharide can activate 70Z/3 cells via CD14
    • Kirkland T., Viriyakosol S., Perez-Perez G.I., Blaser M.J. Helicobacter pylori lipopolysaccharide can activate 70Z/3 cells via CD14. Infect. Immun. 65:1997;604-608.
    • (1997) Infect. Immun. , vol.65 , pp. 604-608
    • Kirkland, T.1    Viriyakosol, S.2    Perez-Perez, G.I.3    Blaser, M.J.4
  • 15
    • 0035977010 scopus 로고    scopus 로고
    • Distinct mechanism of Helicobacter pylori-mediated NF-κB activation between gastric cancer cells and monocytic cells
    • Maeda S., Akanuma M., Mitsuno Y., Hirata Y., Ogura K., Yoshida H., Shiratori Y., Omata M. Distinct mechanism of Helicobacter pylori-mediated NF-κB activation between gastric cancer cells and monocytic cells. J. Biol. Chem. 276:2001;44856-44864.
    • (2001) J. Biol. Chem. , vol.276 , pp. 44856-44864
    • Maeda, S.1    Akanuma, M.2    Mitsuno, Y.3    Hirata, Y.4    Ogura, K.5    Yoshida, H.6    Shiratori, Y.7    Omata, M.8
  • 16
    • 0034001098 scopus 로고    scopus 로고
    • Helicobacter pylori water-soluble surface proteins activate human neutrophils and up-regulate expression of CXC chemokines
    • Kim J.S., Jung H.C., Kim J.M., Song I.S., Kim C.Y. Helicobacter pylori water-soluble surface proteins activate human neutrophils and up-regulate expression of CXC chemokines. Dig. Dis. Sci. 45:2000;83-92.
    • (2000) Dig. Dis. Sci. , vol.45 , pp. 83-92
    • Kim, J.S.1    Jung, H.C.2    Kim, J.M.3    Song, I.S.4    Kim, C.Y.5
  • 17
    • 0028241385 scopus 로고
    • Neutrophil activation by Helicobacter pylori lipopolysaccharides
    • Nielsen H., Birkholz S., Andersen L.P., Moran A.P. Neutrophil activation by Helicobacter pylori lipopolysaccharides. J. Infect. Dis. 170:1994;135-139.
    • (1994) J. Infect. Dis. , vol.170 , pp. 135-139
    • Nielsen, H.1    Birkholz, S.2    Andersen, L.P.3    Moran, A.P.4
  • 19
    • 0031899363 scopus 로고    scopus 로고
    • Proteins encoded by the cag pathogenicity island of Helicobacter pylori are required for NF-κB activation
    • Glocker E., Lange C., Covacci A., Bereswill S., Kist M., Pahl H.L. Proteins encoded by the cag pathogenicity island of Helicobacter pylori are required for NF-κB activation. Infect. Immun. 66:1998;2346-2348.
    • (1998) Infect. Immun. , vol.66 , pp. 2346-2348
    • Glocker, E.1    Lange, C.2    Covacci, A.3    Bereswill, S.4    Kist, M.5    Pahl, H.L.6
  • 20
    • 0033571334 scopus 로고    scopus 로고
    • Differential activation of mitogen-activated protein kinases in AGS gastric epithelial cells by cag+ and cag- Helicobacter pylori
    • Keates S., Keates A.C., Warny M., Peek R.M.J., Murray P.G., Kelly C.P. Differential activation of mitogen-activated protein kinases in AGS gastric epithelial cells by cag+ and cag- Helicobacter pylori. J. Immunol. 163:1999;5552-5559.
    • (1999) J. Immunol. , vol.163 , pp. 5552-5559
    • Keates, S.1    Keates, A.C.2    Warny, M.3    Peek, R.M.J.4    Murray, P.G.5    Kelly, C.P.6
  • 21
    • 0034671936 scopus 로고    scopus 로고
    • P21-activated kinase 1 activates the nuclear factor κb (NF-κB)-inducing kinase-IκB kinases NF-κB pathway and proinflammatory cytokines in Helicobacter pylori infection
    • Foryst-Ludwig A., Naumann M. p21-activated kinase 1 activates the nuclear factor κB (NF-κB)-inducing kinase-IκB kinases NF-κB pathway and proinflammatory cytokines in Helicobacter pylori infection. J. Biol. Chem. 275:2000;39779-39785.
    • (2000) J. Biol. Chem. , vol.275 , pp. 39779-39785
    • Foryst-Ludwig, A.1    Naumann, M.2
  • 22
    • 0035877274 scopus 로고    scopus 로고
    • Mechanism for Helicobacter pylori stimulation of interleukin-8 production in a gastric epithelial cell line (MKN 28): Roles of mitogen-activated protein kinase and interleukin-1beta
    • Yamada H., Aihara T., Okabe S. Mechanism for Helicobacter pylori stimulation of interleukin-8 production in a gastric epithelial cell line (MKN 28): roles of mitogen-activated protein kinase and interleukin-1beta. Biochem. Pharmacol. 61:2001;1595-1604.
    • (2001) Biochem. Pharmacol. , vol.61 , pp. 1595-1604
    • Yamada, H.1    Aihara, T.2    Okabe, S.3
  • 23
    • 0036639484 scopus 로고    scopus 로고
    • Identification of a signaling cascade for interleukin-8 production by Helicobacter pylori in human gastric epithelial cells
    • Nozawa Y., Nishihara K., Peek R.M., Nakano M., Uji T., Ajioka H., Matsuura N., Miyake H. Identification of a signaling cascade for interleukin-8 production by Helicobacter pylori in human gastric epithelial cells. Biochem. Pharmacol. 64:2002;21-30.
    • (2002) Biochem. Pharmacol. , vol.64 , pp. 21-30
    • Nozawa, Y.1    Nishihara, K.2    Peek, R.M.3    Nakano, M.4    Uji, T.5    Ajioka, H.6    Matsuura, N.7    Miyake, H.8
  • 25
    • 0037069449 scopus 로고    scopus 로고
    • Cag pathogenicity island-specific responses of gastric epithelial cells to Helicobacter pylori infection
    • Guillemin K., Salama N.R., Tompkins L.S., Falkow S. Cag pathogenicity island-specific responses of gastric epithelial cells to Helicobacter pylori infection. Proc. Natl. Acad. Sci. USA. 99:2002;15136-15141.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 15136-15141
    • Guillemin, K.1    Salama, N.R.2    Tompkins, L.S.3    Falkow, S.4
  • 28
    • 0030002653 scopus 로고    scopus 로고
    • Colonization of gnotobiotic piglets by Helicobacter pylori deficient in two flagellin genes
    • Eaton K.A., Suerbaum S., Josenhans C., Krakowka S. Colonization of gnotobiotic piglets by Helicobacter pylori deficient in two flagellin genes. Infect. Immun. 64:1996;2445-2448.
    • (1996) Infect. Immun. , vol.64 , pp. 2445-2448
    • Eaton, K.A.1    Suerbaum, S.2    Josenhans, C.3    Krakowka, S.4
  • 30
    • 0026096795 scopus 로고
    • Identification, characterization, and spatial localization of two flagellin species in Helicobacter pylori flagella
    • Kostrzynska M., Betts J.D., Austin J.W., Trust T.J. Identification, characterization, and spatial localization of two flagellin species in Helicobacter pylori flagella. J. Bacteriol. 173:1991;937-946.
    • (1991) J. Bacteriol. , vol.173 , pp. 937-946
    • Kostrzynska, M.1    Betts, J.D.2    Austin, J.W.3    Trust, T.J.4
  • 31
    • 0027252455 scopus 로고
    • Cloning and genetic characterization of the Helicobacter pylori and Helicobacter mustelae flaB flagellin genes and construction of H. pylori flaA- and flaB-negative mutants by electroporation-mediated allelic exchange
    • Suerbaum S., Josenhans C., Labigne A. Cloning and genetic characterization of the Helicobacter pylori and Helicobacter mustelae flaB flagellin genes and construction of H. pylori flaA- and flaB-negative mutants by electroporation-mediated allelic exchange. J. Bacteriol. 175:1993;3278-3288.
    • (1993) J. Bacteriol. , vol.175 , pp. 3278-3288
    • Suerbaum, S.1    Josenhans, C.2    Labigne, A.3
  • 32
    • 0026753106 scopus 로고
    • Construction of isogenic urease-negative mutants of Helicobacter pylori by allelic exchange
    • Ferrero R.L., Cussac V., Courcoux P., Labigne A. Construction of isogenic urease-negative mutants of Helicobacter pylori by allelic exchange. J. Bacteriol. 174:1992;4212-4217.
    • (1992) J. Bacteriol. , vol.174 , pp. 4212-4217
    • Ferrero, R.L.1    Cussac, V.2    Courcoux, P.3    Labigne, A.4
  • 33
    • 0030835739 scopus 로고    scopus 로고
    • The complete genome sequence of the gastric pathogen Helicobacter pylori
    • Tomb J.-F., White O., Kerlavage A.R., et al. The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature. 388:1997;539-547.
    • (1997) Nature , vol.388 , pp. 539-547
    • Tomb, J.-F.1    White, O.2    Kerlavage, A.R.3
  • 34
    • 0033915316 scopus 로고    scopus 로고
    • Switching of flagellar motility in Helicobacter pylori by reversible length variation of a short homopolymeric sequence repeat in fliP, a gene encoding a basal body protein
    • Josenhans C., Eaton K.A., Thevenot T., Suerbaum S. Switching of flagellar motility in Helicobacter pylori by reversible length variation of a short homopolymeric sequence repeat in fliP, a gene encoding a basal body protein. Infect. Immun. 68:2000;4598-4603.
    • (2000) Infect. Immun. , vol.68 , pp. 4598-4603
    • Josenhans, C.1    Eaton, K.A.2    Thevenot, T.3    Suerbaum, S.4
  • 35
    • 0031039252 scopus 로고    scopus 로고
    • Cloning and characterization of the Helicobacter pylori flbA gene, which codes for a membrane protein involved in coordinated expression of flagellar genes
    • Schmitz A., Josenhans C., Suerbaum S. Cloning and characterization of the Helicobacter pylori flbA gene, which codes for a membrane protein involved in coordinated expression of flagellar genes. J. Bacteriol. 179:1997;987-997.
    • (1997) J. Bacteriol. , vol.179 , pp. 987-997
    • Schmitz, A.1    Josenhans, C.2    Suerbaum, S.3
  • 36
    • 0033552961 scopus 로고    scopus 로고
    • Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori
    • Alm R.A., Ling L.-S.L, Moir D.T., et al. Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori. Nature. 397:1999;176-180.
    • (1999) Nature , vol.397 , pp. 176-180
    • Alm, R.A.1    Ling, L.-S.L.2    Moir, D.T.3
  • 37
    • 0035909914 scopus 로고    scopus 로고
    • Recombination and mutation during long-term gastric colonization by Helicobacter pylori: Estimates of clock rates, recombination size and minimal age
    • Falush D., Kraft C., Correa P., Taylor N.S., Fox J.G., Achtman M., Suerbaum S. Recombination and mutation during long-term gastric colonization by Helicobacter pylori: estimates of clock rates, recombination size and minimal age. Proc. Natl. Acad. Sci. USA. 98:2001;15056-15061.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 15056-15061
    • Falush, D.1    Kraft, C.2    Correa, P.3    Taylor, N.S.4    Fox, J.G.5    Achtman, M.6    Suerbaum, S.7
  • 38
    • 0003903343 scopus 로고
    • J. Sambrook, E.F. Fritsch, & T. Maniatis. Cold Spring Harbor: Cold Spring Harbor Laboratory Press
    • Sambrook J., Fritsch E.F., Maniatis T. Molecular Cloning: a Laboratory Manual, 2nd ed. 1989;Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
    • (1989) Molecular Cloning: A Laboratory Manual, 2nd Ed.
  • 39
    • 0026769011 scopus 로고
    • Cloning and genetic characterization of a Helicobacter pylori flagellin gene
    • Leying H., Suerbaum S., Geis G., Haas R. Cloning and genetic characterization of a Helicobacter pylori flagellin gene. Mol. Microbiol. 6:1992;2863-2874.
    • (1992) Mol. Microbiol. , vol.6 , pp. 2863-2874
    • Leying, H.1    Suerbaum, S.2    Geis, G.3    Haas, R.4
  • 40
    • 0026737755 scopus 로고
    • Terminal disorder: A common structural feature of the axial proteins of bacterial flagellum
    • Vonderviszt F., Ishima R., Akasaka K., Aizawa S.-I. Terminal disorder: a common structural feature of the axial proteins of bacterial flagellum. J. Mol. Biol. 226:1992;575-579.
    • (1992) J. Mol. Biol. , vol.226 , pp. 575-579
    • Vonderviszt, F.1    Ishima, R.2    Akasaka, K.3    Aizawa, S.-I.4
  • 41
    • 0035881675 scopus 로고    scopus 로고
    • Cutting edge: Bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression
    • Gewirtz A.T., Navas T.A., Lyons S., Godowski P.J., Madara J.L. Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression. J. Immunol. 167:2001;1882-1885.
    • (2001) J. Immunol. , vol.167 , pp. 1882-1885
    • Gewirtz, A.T.1    Navas, T.A.2    Lyons, S.3    Godowski, P.J.4    Madara, J.L.5
  • 43
    • 0029019564 scopus 로고
    • Comparative ultrastructural and functional studies of Helicobacter pylori and Helicobacter mustelae flagellin mutants: Both flagellin subunits, FlaA and FlaB, are necessary for full motility in Helicobacter species
    • Josenhans C., Labigne A., Suerbaum S. Comparative ultrastructural and functional studies of Helicobacter pylori and Helicobacter mustelae flagellin mutants: both flagellin subunits, FlaA and FlaB, are necessary for full motility in Helicobacter species. J. Bacteriol. 177:1995;3010-3020.
    • (1995) J. Bacteriol. , vol.177 , pp. 3010-3020
    • Josenhans, C.1    Labigne, A.2    Suerbaum, S.3
  • 45
    • 0033916226 scopus 로고    scopus 로고
    • Adherence of isogenic flagella negative mutants of Helicobacter pylori and Helicobacter mustelae to primary human and ferret gastric epithelial cells
    • Clyne M., O'Croinin T., Suerbaum S., Josenhans C., Drumm B. Adherence of isogenic flagella negative mutants of Helicobacter pylori and Helicobacter mustelae to primary human and ferret gastric epithelial cells. Infect. Immun. 68:2000;4335-4339.
    • (2000) Infect. Immun. , vol.68 , pp. 4335-4339
    • Clyne, M.1    O'Croinin, T.2    Suerbaum, S.3    Josenhans, C.4    Drumm, B.5
  • 46
    • 0038222345 scopus 로고    scopus 로고
    • The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells
    • Means T.K., Hayashi F., Smith K.D., Aderem A., Luster A.D. The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells. J. Immunol. 170:2003;5165-5175.
    • (2003) J. Immunol. , vol.170 , pp. 5165-5175
    • Means, T.K.1    Hayashi, F.2    Smith, K.D.3    Aderem, A.4    Luster, A.D.5
  • 47
    • 0033945681 scopus 로고    scopus 로고
    • Enteroaggregative Escherichia coli expresses a novel flagellin that causes IL-8 release from intestinal epithelial cells
    • Steiner T.S., Nataro J.P., Poteet-Smith C.E., Smith J.A., Guerrant R.L. Enteroaggregative Escherichia coli expresses a novel flagellin that causes IL-8 release from intestinal epithelial cells. J. Clin. Invest. 105:2000;1769-1777.
    • (2000) J. Clin. Invest. , vol.105 , pp. 1769-1777
    • Steiner, T.S.1    Nataro, J.P.2    Poteet-Smith, C.E.3    Smith, J.A.4    Guerrant, R.L.5
  • 48
    • 0037560879 scopus 로고    scopus 로고
    • Structural, genetic and functional characterization of the flagellin glycosylation process in Helicobacter pylori
    • Schirm M., Soo E.C., Aubry A.J., Austin J., Thibault P., Logan S.M. Structural, genetic and functional characterization of the flagellin glycosylation process in Helicobacter pylori. Mol. Microbiol. 48:2003;1579-1592.
    • (2003) Mol. Microbiol. , vol.48 , pp. 1579-1592
    • Schirm, M.1    Soo, E.C.2    Aubry, A.J.3    Austin, J.4    Thibault, P.5    Logan, S.M.6
  • 49
    • 0033796984 scopus 로고    scopus 로고
    • High-affinity interaction between Gram-negative flagellin and a cell surface polypeptide results in human monocyte activation
    • McDermott P.F., Ciacci-Woolwine F., Snipes J.A., Mizel S.B. High-affinity interaction between Gram-negative flagellin and a cell surface polypeptide results in human monocyte activation. Infect. Immun. 68:2000;5525-5529.
    • (2000) Infect. Immun. , vol.68 , pp. 5525-5529
    • McDermott, P.F.1    Ciacci-Woolwine, F.2    Snipes, J.A.3    Mizel, S.B.4
  • 51
    • 0037174919 scopus 로고    scopus 로고
    • Two nonadjacent regions in enteroaggregative Escherichia coli flagellin are required for activation of toll-like receptor 5
    • Donnelly M.A., Steiner T.S. Two nonadjacent regions in enteroaggregative Escherichia coli flagellin are required for activation of toll-like receptor 5. J. Biol. Chem. 277:2002;40456-40461.
    • (2002) J. Biol. Chem. , vol.277 , pp. 40456-40461
    • Donnelly, M.A.1    Steiner, T.S.2
  • 52
    • 0037035408 scopus 로고    scopus 로고
    • The neuA/flmD gene cluster of Helicobacter pylori is involved in flagellar biosynthesis and flagellin glycosylation
    • Josenhans C., Vossebein L., Friedrich S., Suerbaum S. The neuA/flmD gene cluster of Helicobacter pylori is involved in flagellar biosynthesis and flagellin glycosylation. FEMS Microbiol. Lett. 210:2002;165-172.
    • (2002) FEMS Microbiol. Lett. , vol.210 , pp. 165-172
    • Josenhans, C.1    Vossebein, L.2    Friedrich, S.3    Suerbaum, S.4
  • 53
  • 54
    • 0038607406 scopus 로고    scopus 로고
    • Identification of a sequence in human toll-like receptor 5 required for the binding of Gram-negative flagellin
    • Mizel S.B., West A.P., Hantgan R.R. Identification of a sequence in human toll-like receptor 5 required for the binding of Gram-negative flagellin. J. Biol. Chem. 278:2003;23624-23629.
    • (2003) J. Biol. Chem. , vol.278 , pp. 23624-23629
    • Mizel, S.B.1    West, A.P.2    Hantgan, R.R.3
  • 55
    • 0035892911 scopus 로고    scopus 로고
    • Salmonella flagellin-dependent proinflammatory responses are localized to the conserved amino and carboxyl regions of the protein
    • Eaves-Pyles T.D., Wong H.R., Odoms K., Pyles R.B. Salmonella flagellin-dependent proinflammatory responses are localized to the conserved amino and carboxyl regions of the protein. J. Immunol. 167:2001;7009-7016.
    • (2001) J. Immunol. , vol.167 , pp. 7009-7016
    • Eaves-Pyles, T.D.1    Wong, H.R.2    Odoms, K.3    Pyles, R.B.4
  • 57
    • 0037066502 scopus 로고    scopus 로고
    • Decoding the patterns of self and nonself by the innate immune system
    • Medzhitov R., Janeway C.A. Jr. Decoding the patterns of self and nonself by the innate immune system. Science. 296:2002;298-300.
    • (2002) Science , vol.296 , pp. 298-300
    • Medzhitov, R.1    Janeway Jr., C.A.2


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