Lack of lung tissue and systemic accumulation after consecutive daily aerosols of amikacin in ventilated piglets with healthy lungs

Anesthesiology

Volumn 98, Issue 4, 2003, Pages 1016-1019

  Ferrari, Fabio ^a,b   Goldstein, Ivan ^g   Nieszkowszka, Ania ^a   Elman, Marilia ^a,c   Marquette, Charles Hugo ^d   Rouby, Jean Jacques ^a,e   Lechat, Philippe ^a   Aymard, Guy ^a   Nicolas Robin, Armelle ^a   Lu, Qin ^a   Coriat, Pierre ^a   Petitjean, Olivier ^f   Louchahi, Kamel ^f  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^b SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^c FACULDADE DE CIÊNCIAS MÉDICAS DA SANTA CASA DE SÃO PAULO   (Brazil)

^d UNIV LILLE   (France)

^e SORBONNE UNIVERSITÉ   (France)

^f AVICENNE HOSPITAL   (France)

^g Avicenne Hospital ^*

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN;

AEROSOL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; ARTIFICIAL VENTILATION; DRUG ABSORPTION; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG TISSUE LEVEL; LUNG PARENCHYMA; NONHUMAN; PRIORITY JOURNAL; SWINE;

ADMINISTRATION, INHALATION; AEROSOLS; AMIKACIN; ANESTHESIA; ANIMALS; ANTI-BACTERIAL AGENTS; AREA UNDER CURVE; LUNG; RESPIRATION, ARTIFICIAL; SWINE; TISSUE DISTRIBUTION;

EID: 0344211927     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-200304000-00033     Document Type: Article

References (6)

1. Goldstein I, Wallet F, Robert J, Becquemin MH, Marquette CH, Rouby JJ: Lung tissue concentrations of nebulized amikacin during mechanical ventilation in piglets with healthy lungs. Am J Respir Crit Care Med 2002; 165:171-5
2. Elman M, Goldstein I, Marquette CH, Wallet F, Lenaour G, Rouby JJ: Influence of lung aeration on pulmonary concentrations of nebulized and intravenous amikacin in ventilated piglets with severe bronchopneumonia. ANESTHESIOLOGY 2002; 97:199-206
3. Marquette CH, Wermert D, Wallet F, Copin MC, Tonnel AB: Characterization of an animal model of ventilator-acquired pneumonia. Chest 1999; 115: 200-9
4. Illowite JS, Gorvoy JD, Smaldone GC: Quantitative deposition of aerosolized gentamicin in cystic fibrosis. Am Rev Respir Dis 1987; 136:1445-9
5. Mingeot-Leclercq MP, Tulkens PM: Aminoglycosides: Nephrotoxicity. Antimicrob Agents Chemother 1999; 43:1003-12
6. Goldstein I, Wallet F, Nicolas-Robin A, Ferrari F, Becquemin MH, Marquette CH, Rouby JJ: Lung deposition and efficiency of nebulized amikacin during experimental pneumonia in piglets. Am J Respir Crit Care Med 2002; 166: 1375-81