Adducts with haemoglobin and with DNA in epichlorohydrin-exposed rats

Chemico-Biological Interactions

Volumn 117, Issue 1, 1999, Pages 49-64

  Hindso Landin H ^a   Segerback D ^b   Damberg, C ^c   Osterman Golkar, S ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Biomarkers; Crosslinking; DNA adducts; Epichlorohydrin; Hemoglobin adducts; Rats

Indexed keywords

BIOLOGICAL MARKER; EPICHLOROHYDRIN; HEMOGLOBIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA ADDUCT; FEMALE; MUTAGENIC ACTIVITY; NONHUMAN; RAT; XENOBIOTIC METABOLISM;

ANIMALS; CARCINOGENS; CROSS-LINKING REAGENTS; DNA; DNA ADDUCTS; DOSE-RESPONSE RELATIONSHIP, DRUG; EPICHLOROHYDRIN; EPOXY COMPOUNDS; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HEMOGLOBINS; MALE; RATS; RATS, INBRED F344; RATS, WISTAR; TRITIUM;

EID: 0344197150     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(98)00099-4     Document Type: Article

References (23)

1. Hine C., Rowe V.K., White E.R., Darmer K.I. Jr., Youngblood G.T. Epoxy compounds. Clayton G.D., Clayton F.E. Patty′s Industrial Hygiene and Toxicology 2A. 3rd edn:1981;2142-2247 Wiley, New York.
2. Van Duuren B.L., Goldschmidt B.M., Katz C., Seideman I., Paul J.S. Carcinogenic activity of alkylating agents. J. Natl. Cancer Inst. 53(3):1974;695-700.
3. Laskin S., Sellakumar A.R., Kuschner M. et al. Inhalation carcinogenicity of epichlorohydrin in noninbred Sprague-Dawley rats. J. Natl. Cancer Inst. 65(4):1980;751-757.
4. International Agency for Research on Cancer (IARC), Monographs on the evaluation of the carcinogenic risk of chemicals to man. Cadmium, nickel, some epoxides, Miscellaneous industrial chemicals and general consideration on volatile anaesthetics, vol. 11, Lyon, 1976, pp. 131-139.
5. Ehrenberg L., Hussain S. Genetic toxicity of some important epoxides. Mutat. Res. 86:1981;1-113.
6. Hindsø Landin H., Osterman-Golkar S., Zorcec V., Törnqvist M. Biomonitoring of epichlorohydrin. Anal. Biochem. 240:1996;1-6.
7. Singh U.S., Decker-Samuelian K., Solomon J.J. Reaction of epichlorohydrin with 2′-deoxynucleosides: characterization of adducts. Chem.-Biol. Interact. 99:1996;109-128.
8. Mazzullo M., Colacci A., Grilli S., Prodi G., Arfellini G. In vivo and in vitro binding of epichlorohydrin to nucleic acids. Cancer Lett. 23:1984;81-90.
9. Törnqvist M. Epoxide adducts to N-terminal valine in hemoglobin. Everse J., Vandergriff K.D., Winslow R.M. 'Methods in Enzymology: Hemoglobin. 231 B:1994;650-657 Academic Press, San Diago, CA.
10. 14C]epichlorohydrin after oral administration to rats. Drug Metab. Disp. 13:1985;333-341.
11. Segerbäck D. Alkylation of DNA and hemoglobin in the mouse following exposure to ethene and ethene oxide. Chem.-Biol. Interact. 45:1983;139-151.
12. Licea Pérez H., Plná K., Osterman-Golkar S. Dosimetry of glycidyl ethers in mice by quantification of haemoglobin adducts. Chem.-Biol. Interact. 103:1997;1-16.
13. Segerbäck D., Osterman-Golkar S., Molholt B., Nilsson R. In vivo tissue dosimetry as a basis for cross-species extrapolation in cancer risk assessment of propylene oxide. Regul. Toxicol. Pharmacol. 20:1994;1-14.
14. Plná K., Segerbäck D., Schweda E.K.H. DNA adduct formation by allyl glycidyl ether. Carcinogenesis. 17(7):1996;1465-1471.
15. Anson M.L., Mirsky A.E. Protein coagulation and its reversal. The preparation of insoluble globin, soluble globin and heme. J. Gen. Physiol. 13:1930;469-476.
16. Ohmori S., Takahashi K., Ikeda M. A fundamental study of quantitative desulfurization of sulfur containing amino acids by Raney Nickel and its character. Z. Naturforschung B. 36:1981;370-374.
17. Wüthrich K. 'NMR of Proteins and Nucleic Acids. 1986;Wiley, New York.
18. Kolman A., Dušinská M. Comparison of propylene oxide and epichlorohydrin effects in two transformation tests (C3H/10T1/2 and SHE cells). Toxicol. Lett. 81:1995;213-221.
19. Lutz K. In vivo covalent binding of organic chemicals to DNA as a quantitative indicator in the process of chemical carcinogenesis. Mutat. Res. 65:1979;289-356.
20. Farmer P.B., Neumann H.-G., Henschler D. Estimation of exposure of man to substances reacting covalently with macromolecules. Arch. Toxicol. 60:1987;251-260.
21. de Petrocellis L., Tortoreto M., Pagialunga S. et al. Determination of epichlorohydrin in blood by gas chromatography and selected ion monitoring. J. Chromatogr. 240:1982;218-223.
22. Rossi A.M., Migliore L., Lascialfari D., Sbrana I., Loprieno N. Genotoxicity, metabolism and blood kinetics of epichlorohydrin in mice. Mutat. Res. 118:1983;213-226.
23. Hindsø Landin H., Grummt T., Laurent C., Tates A. Monitoring of occupational exposure to epichlorohydrin by genetic effects and hemoglobin adducts. Mutat. Res. 381:1997;217-226.