A comparison between stereospecificity of oracin reduction and stereoselectivity of oxidation of 11-dihydrooracin enantiomers in vitro in rat and guinea pig

Chirality

Volumn 11, Issue 5-6, 1999, Pages 510-515

  Skálová, Lenka ^a   Wsól, Vladimír ^a   Szotáková, Barbora ^a   Kvasničková, Eva ^a  

^a Charles University in Prague Faculty of Pharmacy   (Czech Republic)

Author keywords

Biotransformation; Carbonyl reductases; Cytosolic reduction; Cytostatic drug; Hepatocytes; Inter species differences; Microsomal reduction; Reoxidation

Indexed keywords

11 DIHYDROORACIN; CARBONYL REDUCTASE; CYTOSTATIC AGENT; ORACIN; ORACIN REDUCTASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; BIOTRANSFORMATION; CHIRALITY; CONFERENCE PAPER; CONTROLLED STUDY; ENANTIOMER; GUINEA PIG; LIVER CELL; LIVER CYTOSOL; MALE; MICROSOME; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RAT; SPECIES DIFFERENCE; STEREOCHEMISTRY; STEREOSPECIFICITY;

ALCOHOL OXIDOREDUCTASES; ANIMALS; ANTINEOPLASTIC AGENTS; BIOTRANSFORMATION; CYTOSOL; ETHANOLAMINES; GUINEA PIGS; ISOQUINOLINES; LIVER; MALE; MICROSOMES, LIVER; RATS; SPECIES SPECIFICITY; STEREOISOMERISM;

EID: 0344171949     PISSN: 08990042     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-636X(1999)11:5/6<510::AID-CHIR26>3.0.CO;2-G     Document Type: Conference Paper

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