Fermenter balancing for semi-continuous, multi-tank mammalian cell culture processes

Chemical Engineering Journal

Volumn 65, Issue 2, 1997, Pages 123-132

  Dey, S ^a   Marshall, C ^b   Slater, N K H ^a  

^a ASTON UNIVERSITY   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Antibody production; Bioprocess optimisation; Fermenter scheduling

Indexed keywords

ANTIBODIES; FERMENTERS; MANUFACTURE; SCHEDULING;

ANTIBODY PRODUCTION; BIOPROCESS OPTIMISATION; FERMENTER BALANCING;

ANIMAL CELL CULTURE;

EID: 0344157470     PISSN: 13858947     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1385-8947(96)03195-6     Document Type: Article

References (12)

1. R.G. Askin and C.R. Standridge, Modelling and Analysis of Manufacturing Systems, Wiley, New York, 1993.
2. G.V. Reklaitis, Review of scheduling of process operations, AICHE Symp. Ser., 78 (1982) 119-133.
3. E. Ptsidou and J. Kantor, Scheduling of a multipurpose batch plant using a graphically derived mixed integer linear program, Ind. Eng. Chem. Res., 30 (1991) 1548-1561.
4. D.B. Birewar and I.E. Grossman, Incorporating scheduling in the optimal design of multiproduct batch plants, Comput. Chem. Eng., 13(1-2) (1989) 141-161.
5. H.M. Cartwright and R.A. Long, Simultaneous optimisation of chemical flowshop sequencing and topology using genetic algorithms, Ind. Eng. Chem. Res., 32 (1993) 2706-2713.
6. G.P. Pisano and S.C. Wheelwright, The new logic of high-tech R&D, Harvard Business Rev., September-October (1995) 93-105.
7. A. Johnson, Optimisation of fed-batch biotechnical processes, IFAC Modelling and Control of Biotechnical Processes, Colorado, 1992, p. 243.
8. N.J. Samsatli and N. Shah, Integrated bioprocess design, Proc. 1996 Inst. Chem. Eng. Res. Event, pp. 118-120.
9. W.-S. Hu and J.M. Piret, Mammalian cell culture processes, Current Opin. Biotechnol., 3 (1992) 110-114.
10. W.-S. Hu and M.V. Pasha, Animal cell bioreactors - recent advances and challenges to scale-up, Can. J. Chem. Eng., 69 (1991) 409-420.
11. A.S. Lubiniecki and J.H. Lupker, Purified protein products of rDNA technology expressed in animal cell culture, Biologicals, 22 (1994) 161-169.
12. E. Kondili, C.C. Pantelides and R.W.H. Sargent, A general algorithm for short-term scheduling of batch operations. 1. MILP formulation, Comput. Chem. Eng., 17 (1993) 211.