메뉴 건너뛰기




Volumn 92, Issue 1-2, 1998, Pages 160-169

IL-6 deficiency leads to increased emotionality in mice: Evidence in transgenic mice carrying a null mutation for IL-6

Author keywords

Cytokines; Emotionality; Holeboard; IL 6 deficiency; Knock out mice; Plus maze

Indexed keywords

INTERLEUKIN 6;

EID: 0344141247     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(98)00199-4     Document Type: Article
Times cited : (65)

References (64)
  • 1
    • 0026505309 scopus 로고
    • The acute inflammatory response to lipopolysaccharide in CNS parenchyma differs from that in other body tissues
    • Andersson P., Perry V., Gordon S. The acute inflammatory response to lipopolysaccharide in CNS parenchyma differs from that in other body tissues. Neuroscience. 48:1992;169-186.
    • (1992) Neuroscience , vol.48 , pp. 169-186
    • Andersson, P.1    Perry, V.2    Gordon, S.3
  • 2
    • 0015837338 scopus 로고
    • Tests for emotionality in rats and mice: A review
    • Archer J. Tests for emotionality in rats and mice: a review. Anim. Behav. 21:1973;205-235.
    • (1973) Anim. Behav. , vol.21 , pp. 205-235
    • Archer, J.1
  • 3
    • 0025787689 scopus 로고
    • Interleukin 1 receptor antagonist. A new member of the interleukin 1 family
    • Arend W.P. Interleukin 1 receptor antagonist. A new member of the interleukin 1 family. J. Clin. Invest. 88:1991;1445-1451.
    • (1991) J. Clin. Invest. , vol.88 , pp. 1445-1451
    • Arend, W.P.1
  • 4
    • 0022480634 scopus 로고
    • Sensitivity of anterior pituitary hormones to graded levels of psychological stress
    • Armario A., López Calderón A., Jolín T., Castellanos J. Sensitivity of anterior pituitary hormones to graded levels of psychological stress. Life Sci. 39:1986;471-475.
    • (1986) Life Sci. , vol.39 , pp. 471-475
    • Armario, A.1    López Calderón, A.2    Jolín, T.3    Castellanos, J.4
  • 6
    • 0028200994 scopus 로고
    • Genes, environment, and personality
    • Bouchard T.J. Genes, environment, and personality. Science. 264:1994;1700-1701.
    • (1994) Science , vol.264 , pp. 1700-1701
    • Bouchard, T.J.1
  • 8
    • 0028114735 scopus 로고
    • Abnormal fear response and aggressive behavior in mutant mice deficient for alpha-calcium-calmodulin kinase II
    • Chen C., Rainnie D., Greene R., Tonegawa S. Abnormal fear response and aggressive behavior in mutant mice deficient for alpha-calcium-calmodulin kinase II. Science. 266:1994;291-294.
    • (1994) Science , vol.266 , pp. 291-294
    • Chen, C.1    Rainnie, D.2    Greene, R.3    Tonegawa, S.4
  • 9
    • 0025241288 scopus 로고
    • Physiological and behavioral responses to corticotrophin-releasing factor administration: Is CRF a mediator of anxiety or stress responses?
    • Dunn A., Berridge C. Physiological and behavioral responses to corticotrophin-releasing factor administration: is CRF a mediator of anxiety or stress responses? Brain Res. Rev. 15:1990;71-100.
    • (1990) Brain Res. Rev. , vol.15 , pp. 71-100
    • Dunn, A.1    Berridge, C.2
  • 10
    • 0016818575 scopus 로고
    • Validity of head-dipping as a measure of exploration in a modified hole-board
    • File S.E., Wardill A.G. Validity of head-dipping as a measure of exploration in a modified hole-board. Psychopharmacologia. 44:1975;53-59.
    • (1975) Psychopharmacologia , vol.44 , pp. 53-59
    • File, S.E.1    Wardill, A.G.2
  • 11
    • 0023678776 scopus 로고
    • Production of B cell stimulatory factor-2 and interferon gamma in the central nervous system during viral meningitis and encephalitis
    • Frei K., Leist T., Meager A., Gallo P., Leppert D., Zinkernagel R., Fontana A. Production of B cell stimulatory factor-2 and interferon gamma in the central nervous system during viral meningitis and encephalitis. J. Exp. Med. 168:1988;449-453.
    • (1988) J. Exp. Med. , vol.168 , pp. 449-453
    • Frei, K.1    Leist, T.2    Meager, A.3    Gallo, P.4    Leppert, D.5    Zinkernagel, R.6    Fontana, A.7
  • 12
    • 0027309536 scopus 로고
    • Differential expression of interleukin-6 (IL-6) and interleukin-6 receptor (IL-6R) mRNAs in rat hypothalamus
    • Gadient R.A., Otten U. Differential expression of interleukin-6 (IL-6) and interleukin-6 receptor (IL-6R) mRNAs in rat hypothalamus. Neurosci. Lett. 153:1993;13-16.
    • (1993) Neurosci. Lett. , vol.153 , pp. 13-16
    • Gadient, R.A.1    Otten, U.2
  • 13
    • 0028069262 scopus 로고
    • Expression of interleukin-6 (IL-6) and interleukin-6 receptor (IL-6R) mRNAs in rat brain during postnatal development
    • Gadient R.A., Otten U. Expression of interleukin-6 (IL-6) and interleukin-6 receptor (IL-6R) mRNAs in rat brain during postnatal development. Brain Res. 637:1994;10-14.
    • (1994) Brain Res. , vol.637 , pp. 10-14
    • Gadient, R.A.1    Otten, U.2
  • 14
    • 0027949041 scopus 로고
    • Identification of interleukin-6 (IL-6)-expressing neurons in the cerebellum and hippocampus of normal adult rats
    • Gadient R.A., Otten U. Identification of interleukin-6 (IL-6)-expressing neurons in the cerebellum and hippocampus of normal adult rats. Neurosci. Lett. 182:1994;243-246.
    • (1994) Neurosci. Lett. , vol.182 , pp. 243-246
    • Gadient, R.A.1    Otten, U.2
  • 15
    • 0024312483 scopus 로고
    • Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system: An evaluation of cytokines in cerebrospinal fluid
    • Gallo P., Fre K., Rordorf C., Lazdins J., Tavolato B., Fontana A. Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system: an evaluation of cytokines in cerebrospinal fluid. J. Neuroimmunol. 23:1989;109-116.
    • (1989) J. Neuroimmunol. , vol.23 , pp. 109-116
    • Gallo, P.1    Fre, K.2    Rordorf, C.3    Lazdins, J.4    Tavolato, B.5    Fontana, A.6
  • 16
    • 0029940557 scopus 로고    scopus 로고
    • Gene-targeting studies of mammalian behavior: Is it the mutation or the background genotype?
    • Gerlai R. Gene-targeting studies of mammalian behavior: is it the mutation or the background genotype? Trends Neurosci. 19:1996;177-186.
    • (1996) Trends Neurosci. , vol.19 , pp. 177-186
    • Gerlai, R.1
  • 17
    • 0024466595 scopus 로고
    • Interleukin 6 as a neurotrophic factor for promoting the survival of cultured basal forebrain cholinergic neurons from postnatal rats
    • Hama T., Miyamoto M., Tsukui H., Nishio C., Hatanaka H. Interleukin 6 as a neurotrophic factor for promoting the survival of cultured basal forebrain cholinergic neurons from postnatal rats. Neurosci. Lett. 104:1989;340-344.
    • (1989) Neurosci. Lett. , vol.104 , pp. 340-344
    • Hama, T.1    Miyamoto, M.2    Tsukui, H.3    Nishio, C.4    Hatanaka, H.5
  • 18
    • 0026024226 scopus 로고
    • Interleukin-6 improves the survival of mesencephalic catecholaminergic and septal cholinergic neurons from postnatal, two-week-old rats in cultures
    • Hama T., Kushima Y., Miyamoto M., Kubota M., Takei N., Hatanaka H. Interleukin-6 improves the survival of mesencephalic catecholaminergic and septal cholinergic neurons from postnatal, two-week-old rats in cultures. Neuroscience. 40:1991;445-452.
    • (1991) Neuroscience , vol.40 , pp. 445-452
    • Hama, T.1    Kushima, Y.2    Miyamoto, M.3    Kubota, M.4    Takei, N.5    Hatanaka, H.6
  • 19
    • 0005696267 scopus 로고
    • Brain interleukin-1 receptors: mapping, characterization and modulation
    • In: Rothwell, N., Dantzer, R. (Eds.), Pergamon, Oxford, pp.
    • Haour, F., Ban, E., Marquette, C., Milon, G., Fillion, G., 1992. Brain interleukin-1 receptors: mapping, characterization and modulation. In: Rothwell, N., Dantzer, R. (Eds.), Interleukin-1 in the Brain, Pergamon, Oxford, pp. 13-25.
    • (1992) Interleukin-1 in the Brain , pp. 13-25
    • Haour, F.1    Ban, E.2    Marquette, C.3    Milon, G.4    Fillion, G.5
  • 20
    • 0018093997 scopus 로고
    • Sensitive pituitary adrenal responsiveness to varying intensities of psychological stimulation
    • Hennessy M., Levine S. Sensitive pituitary adrenal responsiveness to varying intensities of psychological stimulation. Physiol. Behav. 21:1978;295-297.
    • (1978) Physiol. Behav. , vol.21 , pp. 295-297
    • Hennessy, M.1    Levine, S.2
  • 21
    • 0031028141 scopus 로고    scopus 로고
    • Progressive decline in avoidance learning paralleled by inflammatory neurodegeneration in transgenic mice expressing interleukin 6 in the brain
    • Heyser C.J., Masliah E., Samimi A., Campbell I.L., Gold L.H. Progressive decline in avoidance learning paralleled by inflammatory neurodegeneration in transgenic mice expressing interleukin 6 in the brain. Proc. Natl. Acad. Sci. USA. 94:1997;1500-1505.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 1500-1505
    • Heyser, C.J.1    Masliah, E.2    Samimi, A.3    Campbell, I.L.4    Gold, L.H.5
  • 22
    • 0024366885 scopus 로고
    • Tumor necrosis factor identified in multiple-sclerosis brain
    • Hofman F., Hinton D., Johnson K., Merrill J. Tumor necrosis factor identified in multiple-sclerosis brain. J. Exp. Med. 170:1989;607-612.
    • (1989) J. Exp. Med. , vol.170 , pp. 607-612
    • Hofman, F.1    Hinton, D.2    Johnson, K.3    Merrill, J.4
  • 23
    • 0028800715 scopus 로고
    • Cytokines and the nervous system: I. Expression and recognition
    • Hopkins S., Rothwell N. Cytokines and the nervous system: I. Expression and recognition. Trends Neurosci. 18:1995;83-88.
    • (1995) Trends Neurosci. , vol.18 , pp. 83-88
    • Hopkins, S.1    Rothwell, N.2
  • 24
    • 0023848694 scopus 로고
    • Elevated levels of the 26K human hybridoma growth factor (interleukin 6) in cerebrospinal fluid of patients with acute infection of the central nervous system
    • Houssiau F., Bukasa K., Sindic C., van Dammes J., van Snick J. Elevated levels of the 26K human hybridoma growth factor (interleukin 6) in cerebrospinal fluid of patients with acute infection of the central nervous system. Clin. Exp. Immunol. 71:1988;320-323.
    • (1988) Clin. Exp. Immunol. , vol.71 , pp. 320-323
    • Houssiau, F.1    Bukasa, K.2    Sindic, C.3    Van Dammes, J.4    Van Snick, J.5
  • 25
    • 0025779765 scopus 로고
    • Conditioned taste aversion but not adrenal activity develops to icv administration of interleukin-1 in rats
    • Janz L.J., Brown R., Zuo L., Falk J., Greenberg A.H., Dyck D.G. Conditioned taste aversion but not adrenal activity develops to icv administration of interleukin-1 in rats. Physiol. Behav. 49:1991;691-694.
    • (1991) Physiol. Behav. , vol.49 , pp. 691-694
    • Janz, L.J.1    Brown, R.2    Zuo, L.3    Falk, J.4    Greenberg, A.H.5    Dyck, D.G.6
  • 28
    • 0025945932 scopus 로고
    • Elevated plus-maze: A novel psychobehavioral tool to measure anxiety in rodents
    • Kulkarni S.K., Sharma A.C. Elevated plus-maze: a novel psychobehavioral tool to measure anxiety in rodents. Methods Find. Exp. Clin. Pharmacol. 13:1991;573-577.
    • (1991) Methods Find. Exp. Clin. Pharmacol. , vol.13 , pp. 573-577
    • Kulkarni, S.K.1    Sharma, A.C.2
  • 29
    • 0025372712 scopus 로고
    • The effects of psychological stress on plasma interleukin-6 activity in rats
    • LeMay L.G., Vander A.J., Kluger M.J. The effects of psychological stress on plasma interleukin-6 activity in rats. Physiol. Behav. 47:1990;957-961.
    • (1990) Physiol. Behav. , vol.47 , pp. 957-961
    • Lemay, L.G.1    Vander, A.J.2    Kluger, M.J.3
  • 30
    • 0031049044 scopus 로고    scopus 로고
    • Interleukin-6 inhibits long-term potentiation in rat hippocampal slices
    • Li A.-J., Katafuchi T., Oda S., Hori T., Oomura Y. Interleukin-6 inhibits long-term potentiation in rat hippocampal slices. Brain Res. 748:1997;30-38.
    • (1997) Brain Res. , vol.748 , pp. 30-38
    • Li, A.-J.1    Katafuchi, T.2    Oda, S.3    Hori, T.4    Oomura, Y.5
  • 31
    • 0025873504 scopus 로고
    • Localization of interleukin-1 receptor antagonist mRNA in rat brain
    • Licinio J., Wong M.L., Gold P.W. Localization of interleukin-1 receptor antagonist mRNA in rat brain. Endocrinology. 129:1991;562-564.
    • (1991) Endocrinology , vol.129 , pp. 562-564
    • Licinio, J.1    Wong, M.L.2    Gold, P.W.3
  • 32
    • 0023255981 scopus 로고
    • The use of a plus-maze to measure anxiety in the mouse
    • Lister R. The use of a plus-maze to measure anxiety in the mouse. Psychopharmacology. 92:1987;180-185.
    • (1987) Psychopharmacology , vol.92 , pp. 180-185
    • Lister, R.1
  • 33
    • 0028846024 scopus 로고
    • Intracerebroventricular interleukin-1 receptor antagonist blocks the enhancement of fear conditioning and interference with escape produced by inescapable shock
    • Maier S.F., Watkins L.R. Intracerebroventricular interleukin-1 receptor antagonist blocks the enhancement of fear conditioning and interference with escape produced by inescapable shock. Brain Res. 695:1995;279-282.
    • (1995) Brain Res. , vol.695 , pp. 279-282
    • Maier, S.F.1    Watkins, L.R.2
  • 34
    • 0024252881 scopus 로고
    • Multivariate analysis of putative measures of activity, exploration, emotionality, and spatial behavior in the hooded rat (Rattus norvegicus)
    • Maier S.E., Vandenhoff P., Crowne D.P. Multivariate analysis of putative measures of activity, exploration, emotionality, and spatial behavior in the hooded rat (Rattus norvegicus). J. Comp. Psychol. 102:1988;378-387.
    • (1988) J. Comp. Psychol. , vol.102 , pp. 378-387
    • Maier, S.E.1    Vandenhoff, P.2    Crowne, D.P.3
  • 36
    • 0029013929 scopus 로고
    • Interactions of the nervous and immune systems in development, normal brain homeostasis, and disease
    • Merrill J.E., Jonakait G.M. Interactions of the nervous and immune systems in development, normal brain homeostasis, and disease. FASEB J. 9:1995;611-618.
    • (1995) FASEB J. , vol.9 , pp. 611-618
    • Merrill, J.E.1    Jonakait, G.M.2
  • 39
    • 0030805736 scopus 로고    scopus 로고
    • Behavioural performance in three substrains of mouse strain 129
    • Montkowski A., Poettig M., Mederer A., Holsboer F. Behavioural performance in three substrains of mouse strain 129. Brain Res. 762:1997;12-18.
    • (1997) Brain Res. , vol.762 , pp. 12-18
    • Montkowski, A.1    Poettig, M.2    Mederer, A.3    Holsboer, F.4
  • 40
    • 0028568612 scopus 로고
    • Cytokines as mediators in the central nervous system
    • Pousset F. Cytokines as mediators in the central nervous system. Biomed. Pharmacother. 48:1994;425-431.
    • (1994) Biomed. Pharmacother. , vol.48 , pp. 425-431
    • Pousset, F.1
  • 41
    • 0028812570 scopus 로고
    • Interleukin-6 selectively enhances the intracellular calcium response to NMDA in developing CNS neurons
    • Qiu Z., Parsons K.L., Gruol D.L. Interleukin-6 selectively enhances the intracellular calcium response to NMDA in developing CNS neurons. J. Neurosci. 15:1995;6688-6699.
    • (1995) J. Neurosci. , vol.15 , pp. 6688-6699
    • Qiu, Z.1    Parsons, K.L.2    Gruol, D.L.3
  • 42
    • 0031439207 scopus 로고    scopus 로고
    • Modulation of hypothalamic-pituitary-adrenal function by transgenic expression of interleukin-6 in the CNS of mice
    • Raber J., O'Shea R., Bloom F., Campbell I. Modulation of hypothalamic-pituitary-adrenal function by transgenic expression of interleukin-6 in the CNS of mice. J. Neurosci. 17:1997;9473-9480.
    • (1997) J. Neurosci. , vol.17 , pp. 9473-9480
    • Raber, J.1    O'Shea, R.2    Bloom, F.3    Campbell, I.4
  • 43
    • 0029560472 scopus 로고
    • Interleukin-6 mRNA expression by cortical neurons in culture: Evidence for neuronal sources of interleukin-6 production in the brain
    • Ringheim G.E., Burgher K.L., Heroux J.A. Interleukin-6 mRNA expression by cortical neurons in culture: evidence for neuronal sources of interleukin-6 production in the brain. J. Neuroimmunol. 63:1995;113-123.
    • (1995) J. Neuroimmunol. , vol.63 , pp. 113-123
    • Ringheim, G.E.1    Burgher, K.L.2    Heroux, J.A.3
  • 44
    • 0030855014 scopus 로고    scopus 로고
    • Behavioral reactivity to aversive stimuli in a transgenic mouse model of impaired glucocorticoid (type II) receptor function: Effects of diazepam and FG-7142
    • Rochford J., Beaulieu S., Rousse I., Glowa J., Barden N. Behavioral reactivity to aversive stimuli in a transgenic mouse model of impaired glucocorticoid (type II) receptor function: effects of diazepam and FG-7142. Psychopharmacology. 132:1997;145-152.
    • (1997) Psychopharmacology , vol.132 , pp. 145-152
    • Rochford, J.1    Beaulieu, S.2    Rousse, I.3    Glowa, J.4    Barden, N.5
  • 45
    • 0026076534 scopus 로고
    • Functions and mechanisms of interleukin 1 in the brain
    • Rothwell N.J. Functions and mechanisms of interleukin 1 in the brain. Trends Physiol. Sci. 12:1991;430-436.
    • (1991) Trends Physiol. Sci. , vol.12 , pp. 430-436
    • Rothwell, N.J.1
  • 46
    • 0028869476 scopus 로고
    • Cytokines and the nervous system: II. Actions and mechanisms of action
    • Rothwell N.J., Hopkins S.J. Cytokines and the nervous system: II. Actions and mechanisms of action. Trends Neurol. Sci. 18:1995;130-136.
    • (1995) Trends Neurol. Sci. , vol.18 , pp. 130-136
    • Rothwell, N.J.1    Hopkins, S.J.2
  • 47
    • 0001692849 scopus 로고
    • On the construct validity of open-field measures
    • Royce J.R. On the construct validity of open-field measures. Psychol. Bull. 84:1977;1098-1106.
    • (1977) Psychol. Bull. , vol.84 , pp. 1098-1106
    • Royce, J.R.1
  • 48
    • 0023691651 scopus 로고
    • Induction of neuronal differentiation of PC12 cells by B cell stimulatory factor 2/interleukin 6
    • Satoh T., Nakamura S., Taga T., Matsuda T., Hirano T., Kishimoto T., Kaziro Y. Induction of neuronal differentiation of PC12 cells by B cell stimulatory factor 2/interleukin 6. Mol. Cell. Biol. 8:1988;3546-3549.
    • (1988) Mol. Cell. Biol. , vol.8 , pp. 3546-3549
    • Satoh, T.1    Nakamura, S.2    Taga, T.3    Matsuda, T.4    Hirano, T.5    Kishimoto, T.6    Kaziro, Y.7
  • 49
    • 0027423232 scopus 로고
    • Cellular localization of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain
    • Schöbitz B., de Kloet E.R., Sutanto W., Holsboer F. Cellular localization of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain. Eur. J. Neurosci. 5:1993;1426-1435.
    • (1993) Eur. J. Neurosci. , vol.5 , pp. 1426-1435
    • Schöbitz, B.1    De Kloet, E.R.2    Sutanto, W.3    Holsboer, F.4
  • 52
    • 0029045856 scopus 로고
    • Strain-dependent epithelial defects in mice lacking the EGF receptor
    • Sibilia M., Wagner E.F. Strain-dependent epithelial defects in mice lacking the EGF receptor. Science. 269:1995;234-238.
    • (1995) Science , vol.269 , pp. 234-238
    • Sibilia, M.1    Wagner, E.F.2
  • 53
    • 0029932137 scopus 로고    scopus 로고
    • Beta-adrenoceptor antagonists suppress elevation in body temperature and increase in plasma IL-6 in rats exposed to open field
    • Soszynski D., Kozak W., Conn C., Rudolph K., Kluger M. Beta-adrenoceptor antagonists suppress elevation in body temperature and increase in plasma IL-6 in rats exposed to open field. Neuroendocrinology. 63:1996;459-467.
    • (1996) Neuroendocrinology , vol.63 , pp. 459-467
    • Soszynski, D.1    Kozak, W.2    Conn, C.3    Rudolph, K.4    Kluger, M.5
  • 54
    • 0028324921 scopus 로고
    • Overproduction of corticotrophin-releasing factor in transgenic mice: A genetic model of anxiogenic behavior
    • Stenzel-Poore M., Heinrichs S., Rivest S., Koob G., Vale W. Overproduction of corticotrophin-releasing factor in transgenic mice: a genetic model of anxiogenic behavior. J. Neurosci. 14:1994;2579-2584.
    • (1994) J. Neurosci. , vol.14 , pp. 2579-2584
    • Stenzel-Poore, M.1    Heinrichs, S.2    Rivest, S.3    Koob, G.4    Vale, W.5
  • 55
    • 0022312028 scopus 로고
    • Higher reliability and closer relationship between open-field test measures on aggregation data
    • Tachibana T. Higher reliability and closer relationship between open-field test measures on aggregation data. Anim. Learn. Behav. 13:1985;345-348.
    • (1985) Anim. Learn. Behav. , vol.13 , pp. 345-348
    • Tachibana, T.1
  • 56
    • 0028245444 scopus 로고
    • Forward and reverse genetic approaches to behavior in the mouse
    • Takahashi J.S., Pinto L.H., Vitaterna M.H. Forward and reverse genetic approaches to behavior in the mouse. Science. 264:1994;1724-1733.
    • (1994) Science , vol.264 , pp. 1724-1733
    • Takahashi, J.S.1    Pinto, L.H.2    Vitaterna, M.H.3
  • 57
    • 0028543542 scopus 로고
    • Immobilization stress may increase plasma interleukin-6 via central and peripheral catecholamines
    • Takaki A., Huang Q.-H., Somogyvári-V A., Arimura A. Immobilization stress may increase plasma interleukin-6 via central and peripheral catecholamines. Neuroimmunomodulation. 1:1994;335-342.
    • (1994) Neuroimmunomodulation , vol.1 , pp. 335-342
    • Takaki, A.1    Huang, Q.-H.2    Somogyvári-V, A.3    Arimura, A.4
  • 58
    • 0029587113 scopus 로고
    • Modulation of interleukin-1 receptors in the brain-endocrine-immune axis by stress and infection
    • Takao T., Hashimoto K., De Souza E.B. Modulation of interleukin-1 receptors in the brain-endocrine-immune axis by stress and infection. Brain Behav. Immun. 9:1995;276-291.
    • (1995) Brain Behav. Immun. , vol.9 , pp. 276-291
    • Takao, T.1    Hashimoto, K.2    De Souza, E.B.3
  • 60
    • 0027273662 scopus 로고
    • Differences in fear motivated behaviors among inbred mouse strains
    • Trullas R., Skolnick P. Differences in fear motivated behaviors among inbred mouse strains. Psychopharmacology. 111:1993;323-331.
    • (1993) Psychopharmacology , vol.111 , pp. 323-331
    • Trullas, R.1    Skolnick, P.2
  • 61
    • 0029999725 scopus 로고    scopus 로고
    • Is IL-6 both a cytokine and a neurotrophic factor?
    • Wagner J.A. Is IL-6 both a cytokine and a neurotrophic factor? J. Exp. Med. 183:1996;2417-2419.
    • (1996) J. Exp. Med. , vol.183 , pp. 2417-2419
    • Wagner, J.A.1
  • 62
    • 0000650706 scopus 로고
    • The open-field test: A critical review
    • Walsh R.N., Cummins R.A. The open-field test: a critical review. Psychol. Bull. 83:1976;482-504.
    • (1976) Psychol. Bull. , vol.83 , pp. 482-504
    • Walsh, R.N.1    Cummins, R.A.2
  • 63
    • 0025820808 scopus 로고
    • Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: Evidence of a role for microglia in cytokine production
    • Woodrofe M., Sarna G., Wadhwa M., Hayes G., Loughlin A., Tinker A., Cuzner M. Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: evidence of a role for microglia in cytokine production. J. Neuroimmunol. 33:1991;227-236.
    • (1991) J. Neuroimmunol. , vol.33 , pp. 227-236
    • Woodrofe, M.1    Sarna, G.2    Wadhwa, M.3    Hayes, G.4    Loughlin, A.5    Tinker, A.6    Cuzner, M.7
  • 64
    • 0027131192 scopus 로고
    • Exposure to physical and psychological stressors elevates plasma interleukin 6: Relationship to the activation of hypothalamic-pituitary-adrenal axis
    • Zhou D., Kusnecov A.W., Shurin M.R., DePaoli M., Rabin B.S. Exposure to physical and psychological stressors elevates plasma interleukin 6: relationship to the activation of hypothalamic-pituitary-adrenal axis. Endocrinology. 133:1993;2523-2530.
    • (1993) Endocrinology , vol.133 , pp. 2523-2530
    • Zhou, D.1    Kusnecov, A.W.2    Shurin, M.R.3    Depaoli, M.4    Rabin, B.S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.