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Volumn 27, Issue SUPPL. 2, 1999, Pages

Development of resistance and perspectives for future therapies against hepatitis B infections: Lessons to be learned from HIV

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; LAMIVUDINE; NUCLEOSIDE ANALOG; PROTEINASE INHIBITOR; RNA DIRECTED DNA POLYMERASE; RNA POLYMERASE;

EID: 0344131411     PISSN: 03008126     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02561672     Document Type: Conference Paper
Times cited : (8)

References (75)
  • 1
    • 2642639623 scopus 로고    scopus 로고
    • Experience with lamivudine against hepatitis B virus
    • Jaeckel, E., Manns, M. P.: Experience with lamivudine against hepatitis B virus, Intervirology 40 (1997) 322-336.
    • (1997) Intervirology , vol.40 , pp. 322-336
    • Jaeckel, E.1    Manns, M.P.2
  • 2
    • 0344965298 scopus 로고    scopus 로고
    • Clinica. Doc. No.: C00529354
    • Hepatitis overview. Clinica. Doc. No.: C00529354 (1997).
    • (1997) Hepatitis Overview
  • 4
    • 0031716163 scopus 로고    scopus 로고
    • Incidence of hepatitis B virus infection in the United States, 1976-1994: Estimates from the National Health and Nutrition Examination Surveys
    • Coleman, P. J., McQuillan, G. M., Moyer, L. A., Lumbert, S. B., Margolis, H. S.; Incidence of hepatitis B virus infection in the United States, 1976-1994: estimates from the National Health and Nutrition Examination Surveys. J. Infect. Dis. 178 (1998) 954-959.
    • (1998) J. Infect. Dis. , vol.178 , pp. 954-959
    • Coleman, P.J.1    McQuillan, G.M.2    Moyer, L.A.3    Lumbert, S.B.4    Margolis, H.S.5
  • 5
    • 0029888920 scopus 로고    scopus 로고
    • Importance of perinatal versus horizontal transmission of hepatitis B virus infection in China
    • Yao, G. B.: Importance of perinatal versus horizontal transmission of hepatitis B virus infection in China. Gut 38 (Suppl. 2) (1996) S39-S42.
    • (1996) Gut , vol.38 , Issue.SUPPL. 2
    • Yao, G.B.1
  • 6
    • 0031758548 scopus 로고    scopus 로고
    • The global epidemiology of hepatitis B: Soz
    • Kane, M. A.: The global epidemiology of hepatitis B: Soz. Präventivmed. 43 (Suppl. 1) (1998) S24-S26.
    • (1998) Präventivmed. , vol.43 , Issue.SUPPL. 1
    • Kane, M.A.1
  • 7
    • 0026658646 scopus 로고
    • Survival and prognostic indicators in hepatitis B surface antigen-positive cirrhosis of the liver
    • de Jongh, F. E., Janssen, H. L., de Man, R. A., Hop, W. C., Sirhalm, S. W., van Blankenstein, M.: Survival and prognostic indicators in hepatitis B surface antigen-positive cirrhosis of the liver (see comments). Gastroenterology 103 (1992) 1630-1635.
    • (1992) Gastroenterology , vol.103 , pp. 1630-1635
    • De Jongh, F.E.1    Janssen, H.L.2    De Man, R.A.3    Hop, W.C.4    Sirhalm, S.W.5    Van Blankenstein, M.6
  • 8
    • 0345681218 scopus 로고
    • Diagnosis
    • Zuckerman, A. J., Thomas, H. C. (eds.): Churchill Livingstone, Edinburgh
    • Decker, R. H.: Diagnosis. In: Zuckerman, A. J., Thomas, H. C. (eds.): Viral hepatitis. Churchill Livingstone, Edinburgh 1993, pp. 165-184.
    • (1993) Viral Hepatitis , pp. 165-184
    • Decker, R.H.1
  • 9
    • 0029803611 scopus 로고    scopus 로고
    • Immunologic aspects of acute and chronic hepatitis B and C
    • Rehermann, B., Manns, M. P.: Immunologic aspects of acute and chronic hepatitis B and C. Curr. Opin. Gastroenterol. 12 (1996) 554-559.
    • (1996) Curr. Opin. Gastroenterol. , vol.12 , pp. 554-559
    • Rehermann, B.1    Manns, M.P.2
  • 10
    • 0029838758 scopus 로고    scopus 로고
    • The hepatitis-B virus persists for decades after patients recover from acute viral hepatitis despite active maintenance of a cytotoxic T-lymphocyte response
    • Rehermann, B., Ferrari, C., Pasquinelli, C., Chisari, F. V.: The hepatitis-B virus persists for decades after patients recover from acute viral hepatitis despite active maintenance of a cytotoxic T-lymphocyte response. Nature Medicine 2 (1996) 1104-1108.
    • (1996) Nature Medicine , vol.2 , pp. 1104-1108
    • Rehermann, B.1    Ferrari, C.2    Pasquinelli, C.3    Chisari, F.V.4
  • 11
    • 0031792389 scopus 로고    scopus 로고
    • The immunopathogenesis of HBV infection
    • Koziel, M. J.: The immunopathogenesis of HBV infection. Antiviral Ther. 3 (Suppl. 3) (1998) 13-24.
    • (1998) Antiviral Ther. , vol.3 , Issue.SUPPL. 3 , pp. 13-24
    • Koziel, M.J.1
  • 12
    • 0345396623 scopus 로고    scopus 로고
    • Doc. No.: PH029050
    • Pharmaprojects, Doc. No.: PH029050 (1999).
    • (1999) Pharmaprojects
  • 13
    • 0033017481 scopus 로고    scopus 로고
    • HBV viral load within subpopulations of peripheral blood mononuclear cells in HBV infection using limiting dilution PCR
    • Trippler, M., zum Buschenfelde, K. H. M., Gerken, G.: HBV viral load within subpopulations of peripheral blood mononuclear cells in HBV infection using limiting dilution PCR. J. Virol. Methods 78 (1999) 129-147.
    • (1999) J. Virol. Methods , vol.78 , pp. 129-147
    • Trippler, M.1    Zum Buschenfelde, K.H.M.2    Gerken, G.3
  • 16
    • 0028610533 scopus 로고
    • Eurohep consensus report on the management of liver transplantation for hepatitis-B virus infection
    • Muller, R., Samuel, D., Fassati, L. R., Benhamou, J. P., Bismuth, H., Alexander, G. J. M.: Eurohep consensus report on the management of liver transplantation for hepatitis-B virus infection. J. Hepatol. 21 (1994) 1140-1143.
    • (1994) J. Hepatol. , vol.21 , pp. 1140-1143
    • Muller, R.1    Samuel, D.2    Fassati, L.R.3    Benhamou, J.P.4    Bismuth, H.5    Alexander, G.J.M.6
  • 17
    • 0031790995 scopus 로고    scopus 로고
    • Advances in the treatment of chronic hepatitis B virus infection
    • Marques A. R., Straus, S. E.: Advances in the treatment of chronic hepatitis B virus infection. Reviews in Medical Virology 8 (1998) 223-234.
    • (1998) Reviews in Medical Virology , vol.8 , pp. 223-234
    • Marques, A.R.1    Straus, S.E.2
  • 18
    • 0032908321 scopus 로고    scopus 로고
    • Evolving therapies for the treatment of viral hepatitis
    • Poordad, F. F., Gish, R. G.: Evolving therapies for the treatment of viral hepatitis. Emerging Drugs 4 (1999) 15-35.
    • (1999) Emerging Drugs , vol.4 , pp. 15-35
    • Poordad, F.F.1    Gish, R.G.2
  • 19
    • 0031927053 scopus 로고    scopus 로고
    • Therapy of viral hepatitis
    • Hoofnagle, J. H.: Therapy of viral hepatitis. Digestion 59 (1998) 563-578.
    • (1998) Digestion , vol.59 , pp. 563-578
    • Hoofnagle, J.H.1
  • 20
    • 0006679374 scopus 로고    scopus 로고
    • Good response to lamivudine therapy in patients with de novo hepatitis B following orthotopic liver transplantation: A pilot study
    • Prieto, M., Cordoba, J., Rayon, J. M., Garcia-Herola, A., Berenguer, M., Carraseo, D., Olaso, V., Mir, J., Berenguer, J.: Good response to lamivudine therapy in patients with de novo hepatitis B following orthotopic liver transplantation: a pilot study. Hepatology 28 (Suppl.) (1998) 348A.
    • (1998) Hepatology , vol.28 , Issue.SUPPL.
    • Prieto, M.1    Cordoba, J.2    Rayon, J.M.3    Garcia-Herola, A.4    Berenguer, M.5    Carraseo, D.6    Olaso, V.7    Mir, J.8    Berenguer, J.9
  • 21
    • 0024846323 scopus 로고
    • Treatment of chronic hepatitis B with IFN: Experience in western countries
    • Perillo, R. P.: Treatment of chronic hepatitis B with IFN: experience in western countries. Semin. Liver Dis. 9 (1989) 240-241.
    • (1989) Semin. Liver Dis. , vol.9 , pp. 240-241
    • Perillo, R.P.1
  • 24
    • 0027320956 scopus 로고
    • NIH, FDA seek lessons from hepatitis-B drug trial death
    • Macilwain, C.: NIH, FDA seek lessons from hepatitis-B drug trial death. Nature 364 (1993) 275.
    • (1993) Nature , vol.364 , pp. 275
    • Macilwain, C.1
  • 25
    • 0028291513 scopus 로고
    • NIH panel report of 'no flaws' in FIAU trial at variance with FDA report, new probe planned
    • Marwick, C.: NIH panel report of 'no flaws' in FIAU trial at variance with FDA report, new probe planned (news). JAMA 272 (1994) 9-11.
    • (1994) JAMA , vol.272 , pp. 9-11
    • Marwick, C.1
  • 28
    • 0030034211 scopus 로고    scopus 로고
    • Ganciclovir treatment of active hepatitis B virus infection in a heart transplant patient
    • Anand, B. S., Yoffe, B., Young, J. B.: Ganciclovir treatment of active hepatitis B virus infection in a heart transplant patient. J. Clin. Gastroenterol. 22 (1996) 144-146.
    • (1996) J. Clin. Gastroenterol. , vol.22 , pp. 144-146
    • Anand, B.S.1    Yoffe, B.2    Young, J.B.3
  • 29
    • 0029647717 scopus 로고
    • FDA advised to license three anti-HIV agents
    • Nelson, H.: FDA advised to license three anti-HIV agents (news). Lancet 346 (1995) 1358.
    • (1995) Lancet , vol.346 , pp. 1358
    • Nelson, H.1
  • 30
    • 0028205185 scopus 로고
    • Metabolism and mechanism of antiretroviral action of purine and pyrimidine derivatives
    • Balzarini, J.: Metabolism and mechanism of antiretroviral action of purine and pyrimidine derivatives. Pharmacy World and Science 16 (1994) 113-126.
    • (1994) Pharmacy World and Science , vol.16 , pp. 113-126
    • Balzarini, J.1
  • 32
    • 0029031381 scopus 로고
    • Mechanism of inhibition of duck hepatitis B virus polymerasc by(-)-beta-L-2′,3′-dideoxy-3′-thiacytidine
    • Severini, A., Liu, X. Y., Wilson, J. S., Tyrrell, D. L.: Mechanism of inhibition of duck hepatitis B virus polymerasc by(-)-beta-L-2′,3′-dideoxy-3′-thiacytidine, Antimicrob. Agents Chemother. 39 (1995) 1430-1435.
    • (1995) Antimicrob. Agents Chemother. , vol.39 , pp. 1430-1435
    • Severini, A.1    Liu, X.Y.2    Wilson, J.S.3    Tyrrell, D.L.4
  • 33
    • 0030598407 scopus 로고    scopus 로고
    • Effect of betaenantiomeric and racemic nucleoside analogues on mitochondrial functions in HepG2 cells. Implications for predicting drug hepatotoxicity
    • Cui, L., Schinazi, R. F., Gosselin, G., Imbach, J. L., Chu, C. K., Rando, R. F., Revankar, G. R., Sommadossi, J. P.: Effect of betaenantiomeric and racemic nucleoside analogues on mitochondrial functions in HepG2 cells. Implications for predicting drug hepatotoxicity. Biochem. Pharmacol. 52 (1996) 1577-1584.
    • (1996) Biochem. Pharmacol. , vol.52 , pp. 1577-1584
    • Cui, L.1    Schinazi, R.F.2    Gosselin, G.3    Imbach, J.L.4    Chu, C.K.5    Rando, R.F.6    Revankar, G.R.7    Sommadossi, J.P.8
  • 34
    • 0000226527 scopus 로고
    • Mitochondrial toxicity of antiviral nucleoside analogues
    • Parker, W. B., Cheng, Y. C.: Mitochondrial toxicity of antiviral nucleoside analogues. J. NIH Res. 6 (1994) 57-61.
    • (1994) J. NIH Res. , vol.6 , pp. 57-61
    • Parker, W.B.1    Cheng, Y.C.2
  • 35
    • 0030032079 scopus 로고    scopus 로고
    • 2′,3′-dideoxy-beta-L-5-fluorocytidine inhibits duck hepatitis B virus reverse transcription and suppresses viral DNA synthesis in hepatocytes, both in vitro and in vivo
    • Zoulim, F., Dannaoui, E., Borel, C., Hantz, O., Lin, T. S., Liu, S. H., Trepo, C., Cheng, Y. C.: 2′,3′-dideoxy-beta-L-5-fluorocytidine inhibits duck hepatitis B virus reverse transcription and suppresses viral DNA synthesis in hepatocytes, both in vitro and in vivo. Antimicrob. Agents Chemother. 40 (1996) 448-453.
    • (1996) Antimicrob. Agents Chemother. , vol.40 , pp. 448-453
    • Zoulim, F.1    Dannaoui, E.2    Borel, C.3    Hantz, O.4    Lin, T.S.5    Liu, S.H.6    Trepo, C.7    Cheng, Y.C.8
  • 38
    • 0344965284 scopus 로고    scopus 로고
    • Doc. No.: S00622582
    • Scrip. Doc. No.: S00622582 (1999).
    • (1999) Scrip.
  • 39
    • 0000388261 scopus 로고    scopus 로고
    • Lamivudine treatment for one year in previously untreated US hepatitis B patients: Histologie improvement and hepatitis B c antigen scroconversion
    • Dienstag, J., Schiff, E. R., Wright, T., Perrillo, R., Hann, H. W., Crowther, L., Woessner, M., Rubin, M., Brown, N., Group US Lamivudine Investigator: Lamivudine treatment for one year in previously untreated US hepatitis B patients: histologie improvement and hepatitis B c antigen scroconversion. Gastroenterology 114 (1998) pA1235.
    • (1998) Gastroenterology , vol.114
    • Dienstag, J.1    Schiff, E.R.2    Wright, T.3    Perrillo, R.4    Hann, H.W.5    Crowther, L.6    Woessner, M.7    Rubin, M.8    Brown, N.9
  • 40
    • 0030179646 scopus 로고    scopus 로고
    • A double blind, placebo controlled study to assess the effect of famciclovir on virus replication in patients with chronic hepatitis B virus infection
    • Main, J., Brown, J. L., Howells, C., Galassini, R., Crossey, M., Karayiannis, P., Georgiou, P., Atkinson, G., Thomas, H. C.: A double blind, placebo controlled study to assess the effect of famciclovir on virus replication in patients with chronic hepatitis B virus infection. J. Virol. Hepatitis 3 (1996) 211-215.
    • (1996) J. Virol. Hepatitis , vol.3 , pp. 211-215
    • Main, J.1    Brown, J.L.2    Howells, C.3    Galassini, R.4    Crossey, M.5    Karayiannis, P.6    Georgiou, P.7    Atkinson, G.8    Thomas, H.C.9
  • 41
    • 0344965282 scopus 로고    scopus 로고
    • Doc. No.: S00620466
    • Scrip, Doc. No.: S00620466, (1999).
    • (1999) Scrip
  • 42
    • 0344102907 scopus 로고    scopus 로고
    • Doc. No.: S006111502
    • Scrip, Doc. No.: S006111502, (1999).
    • (1999) Scrip
  • 44
    • 0142098293 scopus 로고    scopus 로고
    • Mutations in human hepatitis B virus polymerase associated with resistance to lamivudine and famciclovir do not decrease sensitivity to adefovir
    • Xiong, X., Flores, C., Yang, H., Westland, C. E.,Toole, J. J., Gibbs, C. S.: Mutations in human hepatitis B virus polymerase associated with resistance to lamivudine and famciclovir do not decrease sensitivity to adefovir. Antiviral Res. 37 (1998) pA66.
    • (1998) Antiviral Res. , vol.37 , pp. 66
    • Xiong, X.1    Flores, C.2    Yang, H.3    Westland, C.E.4    Toole, J.J.5    Gibbs, C.S.6
  • 45
    • 0345396620 scopus 로고    scopus 로고
    • HBV polymerase mutations associated with resistance to lamivudine and famciclovir do not decrease sensitivity to adefovir
    • Gibbs, C., Flores, C., Yang, H., Westland, C., Toole, J., Xiong, X.: HBV polymerase mutations associated with resistance to lamivudine and famciclovir do not decrease sensitivity to adefovir. J. Hepatol. 28 (Suppl. 1 ) (1998) 111.
    • (1998) J. Hepatol. , vol.28 , Issue.SUPPL. 1 , pp. 111
    • Gibbs, C.1    Flores, C.2    Yang, H.3    Westland, C.4    Toole, J.5    Xiong, X.6
  • 46
    • 0031793849 scopus 로고    scopus 로고
    • Mutations in hepatitis B DNA polymerase associated resistance to lamivudine do not confer resistance to adefovir in vitro
    • Xiong, X. F., Flores, C., Yang, H., Toole, J. J., Gibbs, C. S.: Mutations in hepatitis B DNA polymerase associated resistance to lamivudine do not confer resistance to adefovir in vitro. Hepatology 28 (1998) 1669-1673.
    • (1998) Hepatology , vol.28 , pp. 1669-1673
    • Xiong, X.F.1    Flores, C.2    Yang, H.3    Toole, J.J.4    Gibbs, C.S.5
  • 47
    • 0032951562 scopus 로고    scopus 로고
    • Sensitivity of L-(-)2′,3′-dideoxythiacytidine resistant hepatitis B virus to other antiviral nucleoside analogues
    • Fu, L., Liu, S. H., Cheng, Y. C.: Sensitivity of L-(-)2′,3′-dideoxythiacytidine resistant hepatitis B virus to other antiviral nucleoside analogues. Biochem. Pharmacol. 57 (1999) 1351-1359.
    • (1999) Biochem. Pharmacol. , vol.57 , pp. 1351-1359
    • Fu, L.1    Liu, S.H.2    Cheng, Y.C.3
  • 48
    • 10544253075 scopus 로고    scopus 로고
    • Efficacy of lamivudine in chronic hepatitis B patients with active viral replication and decompensated cirrhosis undergoing liver transplantation
    • Bain, V. G., Kneteman, N. M., Ma, M. M., Gutfreund, K., Shapiro, J. A., Fischer, K., Tipples, G., Lee, H., Jewell, L. D., Tyrrell, D. L.: Efficacy of lamivudine in chronic hepatitis B patients with active viral replication and decompensated cirrhosis undergoing liver transplantation.Transplantation 62 (1996) 1456-1462.
    • (1996) Transplantation , vol.62 , pp. 1456-1462
    • Bain, V.G.1    Kneteman, N.M.2    Ma, M.M.3    Gutfreund, K.4    Shapiro, J.A.5    Fischer, K.6    Tipples, G.7    Lee, H.8    Jewell, L.D.9    Tyrrell, D.L.10
  • 49
    • 0029817898 scopus 로고    scopus 로고
    • Mutation in HBV RNA-dependent DNA-polymerase confers resistance to lamivudine in vivo
    • Tipples, G. A., Ma, M. M., Fischer, K. P., Bain, V. G., Knetemann, N. M., Tyrrell, D. L. J.: Mutation in HBV RNA-dependent DNA-polymerase confers resistance to lamivudine in vivo. Hepatology 24 (1996) 714-717.
    • (1996) Hepatology , vol.24 , pp. 714-717
    • Tipples, G.A.1    Ma, M.M.2    Fischer, K.P.3    Bain, V.G.4    Knetemann, N.M.5    Tyrrell, D.L.J.6
  • 50
    • 0029815110 scopus 로고    scopus 로고
    • Selection of mutations in the hepatitis-B virus polymerase during therapy of transplant recipients with lamivudine
    • Ling, R., Mutimer, D., Ahmed, N., Boxall, E. H., Elias, E., Dusheiko, G. M., Harrison,T. J.: Selection of mutations in the hepatitis-B virus polymerase during therapy of transplant recipients with lamivudine. Hepatology 24 (1996) 711-713.
    • (1996) Hepatology , vol.24 , pp. 711-713
    • Ling, R.1    Mutimer, D.2    Ahmed, N.3    Boxall, E.H.4    Elias, E.5    Dusheiko, G.M.6    Harrison, T.J.7
  • 52
    • 0031900989 scopus 로고    scopus 로고
    • Identification of more than one mutation in the hepatitis B virus polymerase gene arising during prolonged lamivudine treatment
    • Niesters, H. G. M., Honkoop, P., Haagsma, E, B., deMan, R. A., Schalm, S. W., Osterhaus, A. D. M. E.: Identification of more than one mutation in the hepatitis B virus polymerase gene arising during prolonged lamivudine treatment. J. Infect. Dis. 177 (1998) 1382-1385.
    • (1998) J. Infect. Dis. , vol.177 , pp. 1382-1385
    • Niesters, H.G.M.1    Honkoop, P.2    Haagsma, E.B.3    DeMan, R.A.4    Schalm, S.W.5    Osterhaus, A.D.M.E.6
  • 53
    • 0032898178 scopus 로고    scopus 로고
    • Analysis of hepatitis B virus quasispecies changes during emergence and reversion of lamivudine resistance in liver transplantation
    • Cane, P. A., Mutimer, D., Ratcliffe, D., Cook, P., Beards, G., Elias, E., Pillay, D.: Analysis of hepatitis B virus quasispecies changes during emergence and reversion of lamivudine resistance in liver transplantation. Antiviral Ther. 4 (1999) 7-14.
    • (1999) Antiviral Ther. , vol.4 , pp. 7-14
    • Cane, P.A.1    Mutimer, D.2    Ratcliffe, D.3    Cook, P.4    Beards, G.5    Elias, E.6    Pillay, D.7
  • 56
    • 0344212334 scopus 로고    scopus 로고
    • The occurrence of sequential viral mutations in a liver transplant recipient reinfected with hepatitis B: Primary famciclovir resistance followed by a lethal hepatitis during acquired lamivudine resistance
    • De Man, R. A., Bartholomeusz, A., Locarnini, S., Niesters, H. G. M., Zondervan, P. F..: The occurrence of sequential viral mutations in a liver transplant recipient reinfected with hepatitis B: primary famciclovir resistance followed by a lethal hepatitis during acquired lamivudine resistance. J. Hepatol. 26 (Suppl. 1) (1997) 77.
    • (1997) J. Hepatol. , vol.26 , Issue.SUPPL. 1 , pp. 77
    • De Man, R.A.1    Bartholomeusz, A.2    Locarnini, S.3    Niesters, H.G.M.4    Zondervan, P.F.5
  • 57
    • 0032173354 scopus 로고    scopus 로고
    • The sequential occurcnce of viral mutations in liver transplant recipient re-infected with hepatitis B: Hepatitis B immune globulin escape, famciclovir non-response, followed by lamivudine resistance resulting in graft loss
    • deMan, R. A., Bartholomeusz, A. I., Niesters, H. G. M., Zondervan, P. E., Locarnini, S. A.: The sequential occurcnce of viral mutations in liver transplant recipient re-infected with hepatitis B: hepatitis B immune globulin escape, famciclovir non-response, followed by lamivudine resistance resulting in graft loss. J. Hepatol. 29 (1998) 669-675.
    • (1998) J. Hepatol. , vol.29 , pp. 669-675
    • DeMan, R.A.1    Bartholomeusz, A.I.2    Niesters, H.G.M.3    Zondervan, P.E.4    Locarnini, S.A.5
  • 58
    • 0030882376 scopus 로고    scopus 로고
    • Mutations in the hepatitis B virus polymerase gene that are associated with resistance to famciclovir and lamivudine
    • Bartholomeusz, A., Locarnini, S.: Mutations in the hepatitis B virus polymerase gene that are associated with resistance to famciclovir and lamivudine. International Antiviral News 5 (1997) 123-124.
    • (1997) International Antiviral News , vol.5 , pp. 123-124
    • Bartholomeusz, A.1    Locarnini, S.2
  • 59
    • 0344102906 scopus 로고    scopus 로고
    • Emergence of lamivudine resistant HBV is not always associated with HBeAg positive status or a high pre-treatment viral load in patients with chronic infection
    • Whalley, S., Manolakopoulos S., Brown, D., Davies, S., Ling, R., Harrison, T., Dusheiko, G.: Emergence of lamivudine resistant HBV is not always associated with HBeAg positive status or a high pre-treatment viral load in patients with chronic infection. Gut 42 (Suppl. 1) (1998) 14.
    • (1998) Gut , vol.42 , Issue.SUPPL. 1 , pp. 14
    • Whalley, S.1    Manolakopoulos, S.2    Brown, D.3    Davies, S.4    Ling, R.5    Harrison, T.6    Dusheiko, G.7
  • 61
    • 0033031769 scopus 로고    scopus 로고
    • Functional analysis of mutations conferring lamivudine resistance on hepatitis B virus
    • Ling, R., Harrison, T. J.: Functional analysis of mutations conferring lamivudine resistance on hepatitis B virus. J. Gen. Virol. 80 (Part 3) (1999) 601-606.
    • (1999) J. Gen. Virol. , vol.80 , Issue.PART 3 , pp. 601-606
    • Ling, R.1    Harrison, T.J.2
  • 62
    • 0033017849 scopus 로고    scopus 로고
    • YMDD motif in hepatitis B virus DNA polymerase influences on replication and lamivudine resistance: A study by in vitro full-length viral DNA transfection
    • Ono-Nita, S. K., Kato, N., Shiratori, Y., Masaki, T., Lan, K. H., Carrilho, F. J., Omata, M.: YMDD motif in hepatitis B virus DNA polymerase influences on replication and lamivudine resistance: a study by in vitro full-length viral DNA transfection. Hepatology 29 (1999) 939-945.
    • (1999) Hepatology , vol.29 , pp. 939-945
    • Ono-Nita, S.K.1    Kato, N.2    Shiratori, Y.3    Masaki, T.4    Lan, K.H.5    Carrilho, F.J.6    Omata, M.7
  • 63
    • 0032525030 scopus 로고    scopus 로고
    • Role of additional mutations outside the YMDD motif of hepatitis B virus polymcrase in L(-)SddC (3TC) resistance
    • Fu, L., Cheng, Y. C.: Role of additional mutations outside the YMDD motif of hepatitis B virus polymcrase in L(-)SddC (3TC) resistance. Biochem. Pharmacol. 55 (1998) 1567-1572.
    • (1998) Biochem. Pharmacol. , vol.55 , pp. 1567-1572
    • Fu, L.1    Cheng, Y.C.2
  • 64
    • 0031927319 scopus 로고    scopus 로고
    • The M539V polymerase variant in human hepatitis B virus demonstrates resistance 10 2′-deoxy-3′-thiacytidine and a reduced ability to synthesize viral DNA
    • Ladner, S. K., Miller, T. J., King, R. W.: The M539V polymerase variant in human hepatitis B virus demonstrates resistance 10 2′-deoxy-3′-thiacytidine and a reduced ability to synthesize viral DNA. Antimicrob. Agents Chemother. 42 (1998) 2128-2131.
    • (1998) Antimicrob. Agents Chemother. , vol.42 , pp. 2128-2131
    • Ladner, S.K.1    Miller, T.J.2    King, R.W.3
  • 65
    • 0031974697 scopus 로고    scopus 로고
    • The hepatitis B virus M539V polymerase variation responsible for 3TC resistance also confers cross-resistance to other nucleoside analogues
    • Ladner, S. K., Miller, T. J., Otto, M. J., King, R. W.: The hepatitis B virus M539V polymerase variation responsible for 3TC resistance also confers cross-resistance to other nucleoside analogues. Antiviral Chemistry & Chemotherapy 9 (1998) 65-72.
    • (1998) Antiviral Chemistry & Chemotherapy , vol.9 , pp. 65-72
    • Ladner, S.K.1    Miller, T.J.2    Otto, M.J.3    King, R.W.4
  • 68
  • 70
    • 25544445093 scopus 로고    scopus 로고
    • Antiviral therapies: Progress, resistance and trends
    • Rübsamen-Waigmann, H.: Antiviral therapies: progress, resistance and trends. Nova Acta Leopoldina NF 78 (1999) 295-312.
    • (1999) Nova Acta Leopoldina NF , vol.78 , pp. 295-312
    • Rübsamen-Waigmann, H.1
  • 74
    • 0001491974 scopus 로고    scopus 로고
    • Randomised trial in HBeAg negative patients with replicating virus with ganciclovir vs lamivudine in combination with interferon. Evaluation of long-term efficacy
    • Alexopoulou, A., Zafiropoulou, R., Papakonstantinou, A., Hadziyannis, S. J.: Randomised trial in HBeAg negative patients with replicating virus with ganciclovir vs lamivudine in combination with Interferon. Evaluation of long-term efficacy. Hepatology 28 (Suppl.) (1998) 490.
    • (1998) Hepatology , vol.28 , Issue.SUPPL. , pp. 490
    • Alexopoulou, A.1    Zafiropoulou, R.2    Papakonstantinou, A.3    Hadziyannis, S.J.4
  • 75
    • 0001349689 scopus 로고    scopus 로고
    • Combined short-term hepatitis B immunoglobulin (HBIG) and long-term lamivudine versus HBIG monotherapy as hepatitis B virus prophylaxis in liver transplant recipients
    • Terrault, N. A., Wright, T. L., Roberts, J. P., Ascher, N. L.: Combined short-term hepatitis B immunoglobulin (HBIG) and long-term lamivudine versus HBIG monotherapy as hepatitis B virus prophylaxis in liver transplant recipients. Hepatology 28 (Suppl.) (1998) 389.
    • (1998) Hepatology , vol.28 , Issue.SUPPL. , pp. 389
    • Terrault, N.A.1    Wright, T.L.2    Roberts, J.P.3    Ascher, N.L.4


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