Evidence of intra- and extracellular modifications of monoclonal IgG polypeptide chains generating charge heterogeneity

Electrophoresis

Volumn 19, Issue 5, 1998, Pages 767-775

  Mimura, Yusuke ^a   Nakamura, Kazuyuki ^a   Tanaka, Tatehiko ^a   Fujimoto, Masanori ^a  

^a YAMAGUCHI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Aging; Charge shift; Deamidation; Glycosylation; Monoclonal antibody; Two dimensional polyacrylamide gel electrophoresis

Indexed keywords

CHAINS; ELECTROPHORESIS; ENZYME ACTIVITY; MONOCLONAL ANTIBODIES;

CHARGE HETEROGENEITY; CHARGE PROPERTIES; CHARGE SHIFT; DEAMIDATION; EXTRACELLULAR; GLYCOSYLATIONS; HEAVY AND LIGHT CHAINS; POLYPEPTIDES CHAINS; SEMI-LOGARITHMIC PLOTS; TWO-DIMENSIONAL POLYACRYLAMIDE GEL ELECTROPHORESIS;

GLYCOSYLATION;

IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; MONOCLONAL ANTIBODY; POLYPEPTIDE; TUNICAMYCIN;

AGING; AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; IN VITRO STUDY; ISOELECTRIC POINT; MOUSE; NONHUMAN; PEPTIDE MAPPING; PROTEIN GLYCOSYLATION; PROTEIN MODIFICATION; PROTEIN STRUCTURE, FUNCTION AND VARIABILITY; TWO DIMENSIONAL ELECTROPHORESIS;

EID: 0344110518     PISSN: 01730835     EISSN: None     Source Type: Journal    
DOI: 10.1002/elps.1150190528     Document Type: Article

References (35)

1. Askonas, B. A., Biochem. J. 1961, 79, 33-43.
2. Fahey, J. L., J. Clin. Invest. 1963, 42, 111-123.
3. Awdeh, Z. L., Williamson, A. R., Askonas, B. A., Nature 1968, 219, 66-67.
4. Awdeh, Z. L., Williamson, A. R., Askonas, B. A., Biochem. J. 1970, 116, 241-248.
5. Williamson, A. R., Salaman, M. R., Kreth, H. W., Ann. N. Y. Acad. Sci. 1973, 209, 210-224.
6. Latner, A. L., Marshall, T., Gambie, M., Electrophoresis 1980, 1, 82-89.
7. Pearson, T. W., Anderson, N. L., Methods Enzymol. 1983, 92, 196-220.
8. Takeo, K., Suzuno, R., Tanaka, T., Nakamura, K., Electrophoresis 1989, 10, 813-818.
9. Takeo, K., Tanaka, T., Nakamura, K., Suzuno, R., Electrophoresis 1989, 10, 818-824.
10. Mimura, Y., Nakamura, K., Takeo, K., J. Chromatogr. 1992, 597, 345-350.
11. Nakamura, K., Mimura, Y., Takeo, K., Electrophoresis 1993, 14, 81-87.
12. Nakamura, K., Mimura, Y., Tanaka, T., Fujikura, Y., Takeo, K., Electrophoresis 1993, 14, 1338-1340.
13. Mimura, Y., Kabat, E. A., Tanaka, T., Fujimoto, M., Takeo, K., Nakamura, K., Electrophoresis 1995, 16, 116-123.
14. Jefferis, R., Lund, J., Mizutani, H., Nakagawa, H., Kawazoe, Y., Arata, Y., Takahashi, N., Biochem. J. 1990, 268, 529-537.
15. Fujii, S., Nishiura, T., Nishikawa, A., Miura, R., Taniguchi, N., J. Biol. Chem. 1990, 265, 6009-6018.
16. Kimura, K., Nakanishi, M., Ueda, M., Ueno, J., Nariuchi, H., Furukawa, S., Yasuda, T., Immunology 1986, 59, 235-238.
17. Matsuda, T., Kabat, E. A., J. Immunol. 1989, 142, 863-870.
18. Leatherbarrow, R. J., Rademacher, T. W., Dwek, R. A., Mol. Immunol. 1985, 22, 407-415.
19. O'Farrell, P. H., J. Biol. Chem. 1975, 250, 4007-4021.
20. Reisfeld, R. A., Lewis, U. J., Williams, D. E., Nature 1962, 195, 281-283.
21. Cleveland, D. W., Fischer, S. G., Kirschner, M. W., Laemmli, U. K., J. Biol. Chem. 1977, 252, 1102-1106.
22. Laemmli, U. K., Nature 1970, 227, 680-685.
23. Kondo, M., Harada, H., Sunada, S., Yamaguchi, T., Electrophoresis 1991, 12, 685-686.
24. Press, E. M., Piggot, P. J., Porter, R. R., Biochem. J. 1966, 99, 356-366.
25. Middaugh, C. R., Litman, G. W., J. Biol. Chem. 1987, 262, 3671-3673.
26. Lewis, D. A., Guzzetta, A. W., Hancock, W. S., Anal. Chem. 1994, 66, 585-595.
27. Robinson, A. B., McKerrow, J. H., Cary, P., Proc. Natl. Acad. Sci. USA 1970, 66, 753-757.
28. Bischoff, R., Kolbe, H. V. J., J. Chromatogr. B 1994, 662, 261-278.
29. Stephenson, R. C., Clarke, S., J. Biol. Chem. 1989, 264, 6164-6170.
30. Roberts, G. D., Johnson, W. P., Burman, S., Anumula, K. R., Carr, S. A., Anal. Chem. 1995, 67, 3613-3625.
31. Dima, S., Medesan, C., Mota, G., Moraru, I., Sjoquist, J., Ghetie, V., Eur. J. Immunol. 1983, 13, 605-614.
32. Spiegelberg, H. L., Weigle, W. O., J. Exp. Med. 1965, 121, 323-338.
33. Kim, J.-K., Tsen, M.-F., Ghetie, V., Ward, E. S., Eur. J. Immunol. 1994, 24, 542-548.
34. Kim, J.-K., Tsen, M.-F., Ghetie, V., Ward, E. S., Eur. J. Immunol. 1994, 24, 2429-2434.
35. Israel, E. J., Wilsker, D. F., Hayes, K. C., Schoenfeld, D., Simister, N. E., Immunology 1996, 89, 573-578.