Cytokines in the follicular fluid of stimulated and non-stimulated human ovaries; Is ovulation a suppressed inflammatory reaction?

Human Reproduction

Volumn 14, Issue 1, 1999, Pages 162-166

  Buscher U ^a   Chen, F C K ^a   Kentenich, H ^b   Schmiady, H ^b  

^a HUMBOLDT UNIVERSITY   (Germany)

^b NONE

Author keywords

Follicular fluid; Interleukin 1 receptor antagonist; Interleukin 6; Interleukin 8; Ovulation physiology

Indexed keywords

CLOMIFENE; CYTOKINE; ESTRADIOL; FOLLITROPIN; GONADORELIN AGONIST; HUMAN MENOPAUSAL GONADOTROPIN; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; PROGESTERONE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; CELL INTERACTION; DISSOCIATION; FEMALE; FERTILIZATION IN VITRO; HUMAN; INFLAMMATION; OVARY; OVARY CYST; OVARY FOLLICLE; OVARY FOLLICLE FLUID; OVULATION; OVULATION INDUCTION; RUPTURE;

EID: 0344097426     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/14.1.162     Document Type: Article

References (33)

1. Adashi, E.Y., Resnick, C.E., Croft, C.S. et al. (1989) Tumor necrosis factor alpha inhibits gonadotrophin hormonal action in nontransformed ovarian granulosa cells. A modulatory noncylotoxic property. J. Biol. Chem., 264, 11591-11597.
2. Arend, W.P. (1990) Interleukin-1 receptor antagonist: discovery, structure and properties. Prog. Growth Factor Res., 2, 193-205.
3. Arici, A., Oral, E., Bahtiyar, O. et al. (1997) Leukaemia inhibitory factor expression in human follicular fluid and ovarian cells. Hum. Reprod., 12, 1233-1239.
4. Arici, A., Oral, E. Bukulmez, O. et al. (1996) IL-8 expression and modulation in human preovulatory follicles and ovarian cells. Endocrinology, 137, 3762-3769.
5. Barak, V., Mordel, N., Holzer, H. et al. (1992) The correlation between interleukin 1 and tumor necrosis factor to oestradiol, progesterone and testosterone levels in periovulatory follicles of in-vitro fertilization patients. Hum. Reprod., 7, 462-464.
6. Best, C.L. and Hill, J.A. (1995) Interleukin-1α and -β modulation of luteinized human granulosa cell oestrogen and progesterone biosynthesis. Hum. Reprod., 10, 3206-3210.
7. Bonello, N., McKie, K., Jasper, M. et al. (1996) Inhibition of nitric oxide: effects on interleukin-1 beta-enhanced ovulation rate, steroid hormones, and ovarian leukocyte distribution at ovulation in the rat. Biol. Reprod., 54, 436-445.
8. Buyalos, R.P., Watson, J.M. and Martinez-Maza, O. (1992) Detection of interleukin-6 in human follicular fluid. Fertil. Steril., 57, 1230-1234.
9. Chun, S.Y., Daphna-lken, D., Calman, D. et al. (1993) Severe leukocyte depletion does not affect follicular rupture in the rat. Biol. Reprod., 48, 905-909.
10. Dinarello, C.A. and Thompson, R.C. (1991) Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitro. Immunol. Today, 12, 404-410.
11. Goh, H.H. and Ratnam, S.S. (1990) The gonadotrophin surge in humans: its mechanism and role in ovulatory function - a review. Ann. Acad. Med. Singapore, 19, 524-529.
12. Gougeon, A. (1994) Regulation intragonadique de la folliculogenese humaine: faits and hypotheses. Ann. Endocrinol. Paris, 55, 63-73.
13. Hu, S.K., Mitcho, Y.L. and Rath, N.C. (1988) Effect of oestradiol on interleukin 1 synthesis by macrophages. Int. J. Immunopharmacol., 10, 247-252.
14. Hurwitz, A., Loukides, J., Ricciarelli, E. et al. (1992) Human intraovarian interleukin-1 (IL-1) system: highly compartmentalized and hormonally dependent regulation of the genes encoding IL-1, its receptor, and its receptor antagonist. J. Clin. Invest., 89, 1746-1754.
15. Huyser, C., Fourie, F.L., Bosmans, E. et al. (1994) Interleukin-1 beta, interleukin-6, and growth hormone levels in human follicular fluid. J. Assist. Reprod. Genet., 11, 193-202.
16. Jasper, M.L., Brannstrom, M., Olofsson, J.I. et al. (1996) Granulocyte-macrophage colony-stimulating factor: presence in human follicular fluid, protein secretion and mRNA expression by ovarian cells. Mol. Hum. Reprod., 2, 555-562.
17. Kaipia, A. and Hsueh, A.J. (1997) Regulation of ovarian follicle atresia. Annu. Rev. Physiol., 59, 349-363.
18. Kokia, E., Hurwitz, A., Ben-Shlomo, I. et al. (1993) Receptor-mediated stimulatory effect of IL-1 beta on hyaluronic acid and proteoglycan biosynthesis by cultured rat ovarian cells: role for heterologous cell-cell interactions. Endocrinology, 133, 2391-2394.
19. Lipner, H. (1988) Mechanisms of mammalian ovulation. In: Knobil, E., Neil, J. and Lipner, H. (eds) The physiology of reproduction, Ch. 12. Raven Press, New York, p. 447.
20. Loukides, J.A., Loy, R.A., Edwards, R. et al. (1990) Human follicular fluids contain tissue macrophages. J. Clin. Endocrinol. Metab., 71, 1363-1367.
21. Machelon, V., Nome, F., Duran-Gasselin, I. et al. (1995) Macrophage and granulosa interleukin-1 β mRNA in human ovulatory follicles. Hum. Reprod., 10, 2198-2203.
22. Mandrup-Poulsen, T., Nerup, J., Reimers, J.I. et al. (1995) Cytokines and the endocrine system. I. The immunoendocrine network. Eur. J. Endocrinol., 133, 660-671.
23. Oral, E., Seli, E., Bahtiyar, M.O. et al. (1997) Growth-regulated alpha expression in human preovulatory follicles and ovarian cells. Am. J. Reprod. Immunol., 38, 19-25.
24. Pacifici, R., Rifas, L., McCracken, R. et al. (1989) Ovarian steroid treatment blocks a postmenopausal increase in blood monocyte interleukin 1 release. Proc. Natl Acad. Sci. USA, 86, 2398-2402.
25. Polan, M.L., Loukides, J., Nelson, P. et al. (1989) Progesterone and oestradiol modulate interleukin1-β messenger ribonucleic acid levels in cultured human peripheral monocytes. J. Clin. Endocrinol. Metab., 69, 1200-1206.
26. Polan, M.L., Loukides, J.A, and Honig, J. (1994) Interleukin-1 in human ovarian cells and in peripheral blood monocytes increases during the luteal phase: evidence for a midcycle surge in the human. Am. J. Obstet. Gynecol., 170, 1000-1006.
27. Pottratz, S.T., Bellido, T., Mocharla, H. et al. (1994) 17 beta-Oestradiol inhibits expression of human interleukin-6 promoter-reporter constructs by a receptor-dependent mechanism. J. Clin. Invest., 93, 944-950.
28. Runesson, E., Bostrom, E.K., Janson, P.O. et al. (1996) The human preovulatory follicle is a source of the chemotactic cytokine interleukin-8. Mol. Hum. Reprod., 2, 245-250.
29. Vinatier, D., Dufour, P., Tordjeman-Rizzi, N. et al. (1995) Immunological aspects of ovarian function: role of the cytokines. Eur. J. Obstet. Gynecol. Reprod. Biol., 63, 155-168.
30. Wang, L.J. and Norman, R.J. (1992) Concentration of immunoreactive interleukin-1 and interleukin-2 in human preovulatory follicular fluid. Hum. Reprod., 7, 147-150.
31. Wang, L.J., Brannstrom, M., Robertson, S.A. et al. (1992) Tumor necrosis factor alpha in the human ovary: presence in follicular fluid and effects on cell proliferation and prostaglandin production. Fertil. Steril., 58, 934-940.
32. Wang, L.J., Brannstrom, M., Cui, K.H. et al. (1997) Localisation of mRNA for interleukin-1 receptor and interleukin-1 receptor antagonist in the rat ovary. J. Endocrinol., 152, 11-17.
33. Zolti, M., Meirom, R., Shemesh, M. et al. (1990) Granulosa cells as a source and target organ for tumor necrosis factor-alpha. FEBS Lett., 261, 253-255.