Influence of estrogen-progestin treatment on back pain and disability among slim premenopausal women with low lumbar spine bone mineral density: A 2-year placebo-controlled randomized trial

Spine

Volumn 24, Issue 7, 1999, Pages 704-708

  Kyllönen, Eero S ^a   Väänänen, H Kalervo ^b   Vanharanta, J Heikki V ^b   Heikkinen, Jorma E ^b  

^a OULU UNIVERSITY HOSPITAL   (Finland)

^b NONE

Author keywords

Back; Disability; Estrogen; Menopause; Pain; Progestin

Indexed keywords

ESTROGEN; GESTAGEN; NORETHISTERONE ACETATE;

ADULT; ARTICLE; BONE DENSITY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISABILITY; DRUG EFFICACY; ESTROGEN THERAPY; FEMALE; HUMAN; ISCHIALGIA; LOW BACK PAIN; LUMBAR SPINE; PREMENOPAUSE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADULT; BODY MASS INDEX; BONE DENSITY; CIRCADIAN RHYTHM; DISABILITY EVALUATION; ESTRADIOL; FEMALE; FINLAND; FOLLOW-UP STUDIES; HUMANS; INCIDENCE; LOW BACK PAIN; LUMBAR VERTEBRAE; MIDDLE AGED; OSTEOPOROSIS, POSTMENOPAUSAL; PREMENOPAUSE; PROGESTINS; QUESTIONNAIRES;

EID: 0344097276     PISSN: 03622436     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007632-199904010-00018     Document Type: Article

References (40)

1. Adera T, Deyo RA, Donatelle RJ. Premature menopause and low back pain: A population-based study. Ann Epidemiol 1994;4:416-22.
2. Armstrong AL, Oborne J, Coupland CA, Macpherson MB, Bassey EJ, Wallace WA. Effects of hormone replacement therapy on muscle performance and balance in postmenopausal women. Clin Sci 1996;91:685-90.
3. Bellino F. Estrogen metabolism, not biosynthesis, in rabbit articular cartilage and isolated chondrocytes: A preliminary study. Steroids 1992;57:507-10.
4. Bogduk N, Tynan W, Wilson AS. The innervation of the human intervertebral discs. J Anat 1981;132:39-56.
5. Dequeker J, Goris P, Uytterhoeven R. Osteoporosis and osteoarthritis (osteoarthrosis): Anthropometric distinctions. JAMA 1983;18:1448-51.
6. Eyre DR, Muir H. Quantitative analysis of Types I and II collagens in human intervertebral discs at various ages, Biochem Biophys Acta 1976;492:29-42.
7. Fairbank JCT, Couper J, Davies JB, O'Brien JP. The Oswestry low back pain disability questionnaire. Physiotherapy 1980;66:271-3.
8. Grant SF, Reid DM, Blake G, Herd R, Fogelma I, Ralston SH. Reduced bone density and osteoporosis associated with a polymorphic Sp1 binding site in the collagen Type I alpha 1 gene. Nat Genet 1996;14:203-5.
9. Hannan MT, Felson DT, Andersen JJ, Naimark A, Kannel WB. Estrogen use and radiographic osteoarthritis of the knee in women: The Framingham Osteoarthritis Study. Arthritis Rheum 1990;33:525-32.
10. Hassager C, Fabbri-Mabelli G, Christianssen C. The effect of the menopause and hormone replacement therapy on serum carboxyterminal propeptide of Type I collagen. Osteoporosis Int 1993;3:50-2
11. Hassager C, Jensen LT, Podenphant J, Riis BJ, Christiansen C. Collagen synthesis in postmenopausal women during therapy with anabolic steroid or female sex hormones. Metabolism 1990;39:1167-9.
12. Hassager C, Risteli J, Risteli L, Christiansen C. Effect of the menopause and hormone replacement therapy on the carboxyterminal pyridinoline cross-linked telopeptide of Type I collagen. Osteopororsis Int 1994;4:349-52.
13. Heikkinen J, Kyllönen E, Kurttila-Matero E, Wilen-Rosenqvist G, Lankinen K, Väänänen K. Hormone replacement therapy and exercise: Effects on hone density, muscle strength, and lipid metabolism: A placebo-controlled 2-year prospective trial on two estrogen-progestin regimens in healthy postmenopausal women. Maturitas 1997;26:139-49.
14. Heliövaara M, Mäkelä M, Sievers K, et al. Musculoskeletal Diseases in Finland. Helsinki: Publications of the Social Insurance Institution, Finland, 1993; 35:81.
15. Ho KKY, Weissherger AJ. Impact of short-term estrogen administration on growth hormone secretion and action: Distinct route-dependent effects on connective and bone tissue metabolism. J Bone Miner Res 1992;7:821-7.
16. Kaufman JM. Pharmacokinetics of oestogens and hormone replacement therapy. Eur Menopause J 1997;4:14-22.
17. Kröger H, Heikkinen J, Laitinen K, Kotaniemi A. Dual-energy x-ray absorptiometry in normal women: A cross-sectional study of 717 Finnish volunteers. Osteoporosis Int 1992;2:135-40.
18. Kyllönen ES, Heikkinen JE, Väänänen HK, et al. Influence of estrogen-progestin replacement therapy and exercise on lumbar spine mobility and low back symptoms in a healthy early postmenopausal female population: A 2-year randomized controlled trial. Eur Spine J 1998;7:381-6.
19. Lobo RA. Benefits and risks of estrogen replacement therapy. Am J Obstet Gynecol 1995;173:982-9.
20. Million R, Hall W, Haavik Nilsen K, Baker RD, Jayson MIV. Assessment of the progress the back pain patient. Spine 1982;7:204-12.
21. Nevitt MC, Cummings SR, Lane NE, et al. Association of estrogen replacement therapy with the risk of osteoarthritis of the hip in elderly white women: Study of Osteoporotic Fractures Research Group. Arch Intern Med 1996;156: 2073-80.
22. Oliveria SA, Felson DT, Klein RA, Reed JI, Walker AM. Estrogen replacement therapy and the development of osteoarthritis. Epidemiology 1996;7:415-19.
23. Pocock NA, Eisman JA, Hopper JL, Yeates MG, Sam brook PN, Eberl S. Genetic determinants of bone mass in adults: A twin study. J Clin Invest 1987; 80:706-10.
24. Prince RL, Smith M, Dick IM, et al. Prevention of postmenopausal osteoporosis: A comparative study of exercise, calcium supplementation, and hormone replacement therapy. N Engl J Med 1991;325:1189-95.
25. Ralston SH. What's new in osteoporosis? Scott Med J 1995;40:3-5.
26. Rosner IA, Goldberg VM, Getzy L, Moskowitz RW. Effects of estrogen on cartilage and experimentally induced osteoarthritis. Arthritis Rheum 1979;22: 52-8.
27. Ross PD, Davis JW, Epstein RS, Wasnich RD. Pain and disability associated with new vertebral fractures and other spinal conditions. J Clin Epidemiol 1994; 47:231-9.
28. Ryan PJ, Evans P, Gibson T, Fogelman I. Osteoporosis and chronic back pain: A study with single-photon emission computed tomography bone scintigraphy. J Bone Miner Res 1992;7:1455-60.
29. Schneider LS, Farlow M. Combined tacrine and estrogen replacement therapy in patients with Alzhemier's disease. Ann N Y Acad Sci 1997;826:317-22.
30. Schwarzer AC, Aprill CN, Derby R, Fortin J, Kine G, Bogduk N. The prevalence and clinical features of internal disc disruption in patients with chronic low back pain. Spine 1995;20:1878-83.
31. Seeman E, Hopper JL, Young NR, Formica C, Goss P, Tsalamandris C. Do genetic factors explain associations between muscle strength, lean mass, and bone density? A twin study. Am J Physiol 1996;270:E320-7.
32. Sharp CA, Evans SF, Risteli L, Risteli J, Worsfold M, Davie MWJ. Effects of low- and conventional-dose transcutaneous HRT over 2 years on bone metabolism in younger and older postmenopausal women. Eur J Clin Sci 1996;26:763-71.
33. Sheridan PJ, Aufdemorte TB, Holt GR, Gates GA. Cartilage of the baboon contains estrogen receptors. Rheumatol Int 1985;5:279-81.
34. Tsai CL, Liu TK. Up-regulation of estrogen receptors in rabbit osteoarthritic cartilage. Life Sci 1992;50:1727-35.
35. Turner AS, Athanasiou KA, Zhu CF, Alvis MR, Bryant HU. Biochemical effects of estrogen on articular cartilage in ovariectomized sheep. Osteoarthritis Cartilage 1997;5:63-9.
36. Uden A, Åström M, Bergenud H. Pain drawings in chronic back pain: Spine 1988;13:389-92.
37. Urban J. Disc biochemistry in relation to function. In: Wiesel SW, et al, eds. The Lumbar Spine. Vol. 1. 2nd ed. Philadelphia: WB Saunders, 1996:271-3.
38. Ushiyama T, Inoue K, Nishioka J. Expression of estrogen receptor-related protein (p29) and estradiol binding in human arthritic synovium. J Rheumatol 1995;22:421-6.
39. Vanharanta H, Sachs BL, Spivey MA, et al. The relationship of pain provocation to lumbar disc deterioration as seen by CT/discography. Spine 1987;3: 295-8.
40. Yoshizawa H, O'Brien JP, Thomas-Smith W, Trumper M. The neuropathology of intervertebral discs removed for iow back pain. J Pathol 1980;132:95-104.