Alternative splicing of cyclooxygenase-1 mRNA in the human iris

Ophthalmic Research

Volumn 35, Issue 3, 2003, Pages 160-163

  Dröge, Melloney J ^a   Van Sorge, Adriaan A ^b   Van Haeringen, Nicolaas J ^c   Quax, Wim J ^a   Zaagsma, Johan ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b RIJNSTATE HOSPITAL   (Netherlands)

^c NETHERLANDS INSTITUTE FOR NEUROSCIENCE   (Netherlands)

Author keywords

Alternative splicing; Cyclooxygenase 1; Human iris

Indexed keywords

CYCLOOXYGENASE 1; FLURBIPROFEN; MESSENGER RNA;

ADULT; AGED; ALTERNATIVE RNA SPLICING; ARTICLE; BLOOD; CONTROLLED STUDY; DRUG EFFECT; FEMALE; GENE IDENTIFICATION; HUMAN; HUMAN TISSUE; IC 50; IRIS; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE;

AGED; AGED, 80 AND OVER; ALTERNATIVE SPLICING; BLOOD; CYCLOOXYGENASE 1; FEMALE; HUMANS; IRIS; ISOENZYMES; MALE; MEMBRANE PROTEINS; MIDDLE AGED; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 0344088521     PISSN: 00303747     EISSN: None     Source Type: Journal    
DOI: 10.1159/000070052     Document Type: Article

References (13)

1. Needleman P, Turk J, Jakshick BA, Morrison AR, Lefkowith JB: Arachidonic acid metabolism. Annu Rev Biochem 1986;55:69-102.
2. Hla T, Neilson K: Human cyclooxygenase-2 cDNA. Proc Natl Acad Sci USA 1992;89:7384-7388.
3. Yokoyama C, Tanabe T: Cloning of the human gene encoding prostaglandin endoperoxide synthase and primary structure of the enzyme. Biochem Biophys Res Commun 1989;165:888-894.
4. Hla T: Molecular characterization of the 5.2 KB isoforms of the human cyclooxygenase-1 transcript. Prostaglandins 1996;51:81-85.
5. Simmons DL, Xie W, Chipman JG, Evett GE: Multiple cyclooxygenases: Cloning of a mitogen inducible form; in Bailey JM (ed): Prostaglandins, Leukotrienes, Lipoxins, and PAF. New York, Plenum Press, 1991, pp 67-78.
6. Asakura T, Sano N, Shichi H: Prostaglandin synthesis and accumulation by porcin ciliary epithelium. J Ocul Pharmacol 1992;8:333-341.
7. Xie W, Chipman JG, Robertson DL, Erikson RL, Simmons DL: Expression of a mitogen responsive gene encoding prostaglandin synthase is regulated by mRNA splicing. Proc Natl Acad Sci USA 1991;88:2692-2696.
8. Matsuo T, Cynader MS: The EP2 receptor is the predominant prostanoid receptor in the human ciliary muscle. Br J Ophthalmol 1993;77:110-114.
9. Van Haeringen NJ, van Sorge AA, Carballosa Coré-Bodelier VMW: Constitutive cyclooxygenase-1 and induced cyclooxygenase-2 in isolated human iris inhibited by S(+) flurbiprofen. J Ocul Pharmacol Ther 2000;16:353-361.
10. Van Haeringen HJ, van Sorge AA, van Delft JL, Carballosa Coré-Bodelier VMW: Flurbiprofen and enantiomers in ophthalmic solution tested as inhibitors of prostanoid synthesis in human blood. J Ocul Pharmacol Ther 2000;16:345-352.
11. Diaz A, Reginato AM, Jiminez SA: Alternative splicing of human prostaglandin G/H synthase mRNA and evidence of differential regulation of the resulting transcripts by transforming growth factor β1, interleukin 1β, and tumor necrosis factor α. J Biol Chem 1992;267:10816-10822.
12. Kyveris A, Maruscak E, Senchyna M: Optimization of RNA isolation from human ocular tissues and analysis of prostanoid receptor mRNA expression using RT-PCR. Mol Vis 2002;8:51-58.
13. Cáceres JF, Kornblihtt AR: Alternative splicing: Multiple control mechanisms and involvement in human disease. Trends Genet 2002;18:186-193.