Programmed cell death in thymus during experimental paracoccidioidomycosis

Medical Microbiology and Immunology

Volumn 192, Issue 4, 2003, Pages 225-229

  Souto, Paula C S ^a   Brito, Vânia N ^a   Gameiro, Jacy ^a   Da Cruz Höfling, Maria Alice ^a   Verinaud, Liana ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Electron microscopy; Paracoccidioides brasiliensis; Programmed cell death; Thymus; TUNEL

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE TREATMENT; LYMPHOID ORGAN; MALE; MOUSE; NONHUMAN; ORGAN INJURY; PARACOCCIDIOIDES BRASILIENSIS; PRIORITY JOURNAL; SOUTH AMERICAN BLASTOMYCOSIS; THYMUS; THYMUS ATROPHY; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE;

ANIMALS; APOPTOSIS; DISEASE MODELS, ANIMAL; IN SITU NICK-END LABELING; MALE; MICE; MICE, INBRED BALB C; MICROSCOPY, ELECTRON; PARACOCCIDIOIDES; PARACOCCIDIOIDOMYCOSIS; THYMUS GLAND;

EID: 0344082043     PISSN: 03008584     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00430-003-0180-3     Document Type: Article

References (25)

1. Alvarez F, Vellena A, Zapata A, Razquim B (1995) Histopathology of the thymus in Saprolegnia-infected wild brown trout, Salmo trutta L. Vet Immunol Immunopathol 47:163-172
2. Benard G, Mendes-Giannini MJS, Juvenali M, Miranda ET, Duarte AJS (1997) Immunosuppression in paracoccidioidomycosis: T cell hyporesponsivenes to two Paracoccidioides brasiliensis glycoproteins that elicit strong humoral immune response. J Infect Dis 175:1263-1267
3. Brito VN, Souto PCS, Cruz-Höffling MA, Ricci LC, Verinaud L (2002) Thymic invasion and atrophy induced by Paracoccidioides brasiliensis in BALB/c mice. Med Mycol 41:1-5
4. Brummer E, Castaneda E, Restrepo A (1993) Paracoccidioidomycosis: an update. Clin Microbiol Rev 6:89-117
5. Cacere CR, Romano CC, Mendes-Giannini MJS, Duarte AJS, Benard G (2002) The role of apoptosis in the antigen-specific T cell hyporesponsiveness of paracoccidioidomycosis patients. Clin Immunol 105:215-222
6. Castaneda E, Brummer E, Pappagianis D, Stevens DA (1988) Impairment of cellular but not humoral responses in chronic pulmonary and disseminated paracoccidioidomycosis in mice. Infect Immun 56:1771-1777
7. Clarke, PGH (1990) Developmental cell death: morphological diversity and multiple mechanisms. Anat Embryol (Berl) 181:195-213
8. Franco M, Mendes RP, Moscadi-Bacchi M (1989) Paracoccidioidomycosis. Baillière's Clin Trop Med Comm Dis 4:185-220
9. Goldani LZ, Sugar AM (1995) Paracoccidioidomycosis and AIDS: an overview. Clin Infect Dis 21:1275-1281
10. Islam Z, Masahiro N, Yoshizawa T, Yamauchi K, Sakato N (1998) T-2 toxin induces thymic apoptosis in vivo in mice. Toxicol Appl Pharmacol 148:205-214
11. Isogai E, Isogai H, Kimura K, Fujii N, Takagi S, Hirose K, Hayashi M (1996) In vivo induction of apoptosis and immune response in mice by administration of lypopolysaccharide from Porphyromonas gingivalis. Infect Immun 64:1461-1466
12. Jimenez-Finkel BE, Murphy JW (1988) Characterization of efferent T suppressor cells induced by Paracoccidioides brasiliensis-specific afferent T suppressor cells. Infect Immun 56:744-750
13. Kerr JFR, Searle J, Harmon BV, Bishop CJ (1987) Apoptosis. In: Potten CS (ed) Perspectives on mammalian cell death. Oxford University Press, New York, pp 93-128
14. Knaapen MWM, Davies MJ, De Bie M, Haven AJ, Martinet W, Kockx MM (2001) Apoptotic versus autophagic cell death in heart failure. Cardiovasc Res 51:304-312
15. Ozeki Y, Kaneda K, Fujiwara N, Morinoto M, Oka S, Yano I (1997) In vivo induction of apoptosis in the thymus by administration of mycobacterial cord factor (trehalose 6,6′-dimycolate). Infect Immun 65:1793-1799
16. + double-positive thymocytes. J Immunol 164:1689-1694
17. Price P, Olver SD, Gibbons AE, Teo HK, Shellam GR (1993) Characterization of thymic involution induced by murine cytomegalovirus infection. Immunol Cell Biol 71:155-165
18. Roblebo MA, Graybill JR, Ahrens J, Restrepo A, Drutz DJ, Roblebo M (1982) Host defense against experimental paracoccidioidomycosis. Am Rev Respir Dis 125:583-567
19. Sano A, Nobuyuki K, Iabuki K (1993) A comparative study of four different staining methods for estimation of live yeast form cells of P. brasiliensis. Mycopathologia 124:157-161
20. Savino W, Leite-de-Moraes MC, Hontebeyrie-Joskowicz M, Dardenne M (1989) Studies on thymus in Chagas' disease I. Changes in the thymus microenvironment in mice acutely infected with Trypanosoma cruzi. Eur J Immunol 19:1727-1733
21. Silva MR, Marques AS, Campos DS, Taboada DC, Soares GH, Brascher HM, Vargens-Neto JR, Cruz MQ, Labarther NV, Rocha GL, Lima AO (1981) Imunologia na paracoccidioidomicose. An Bras Dermatol 56:227-234
22. Singer-Vermes LM, Caldeira CB, Burger E, Calich VLG (1993) Experimental murine paracoccidioidomycosis: relationship among the dissemination of infection, humoral and cellular responses. Clin Exp Immunol 94:75-79
23. Sotomayor CE, Rubistein HR, Cervi L, Riera CM, Masih DT (1989) Immunosuppression in experimental cryptococcosis in rats: induction of thymic suppressor cells. Mycopathologia 108:5-10
24. Sutton P, Newcombe NR, Waring P, Müllbacher A (1994) In vivo immunosuppressive activity of gliotoxin, a metabolite produced by human pathogenic fungi. Infect Immun 62:1192-1198
25. Teixeira HC, Calich VLG, Singer-Vermes LM, D'Imperio-Lima MR, Russo M (1987) Experimental paracoccidioidomycosis: early immunosuppression occurs in susceptible mice after infection with pathogenic fungi. Braz J Med Biol Res 20:367-369