Crosslinking of cellular DNA by nitracrine and furocoumarin derivatives

Neoplasma

Volumn 46, Issue 1, 1999, Pages 50-53

  Studzian, K ^a   Tolwinska Stanczyk Z ^a   Wilmanska D ^a   Palumbo, M ^b   Gniazdowski, M ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

^b UNIVERSITY OF PADOVA   (Italy)

Author keywords

8 methoxypsoralen; DNA crosslinks; Furocoumarins; L 1210 cells; Nitracrine

Indexed keywords

CELL DNA; DOUBLE STRANDED DNA; FUROCOUMARIN DERIVATIVE; METHOXSALEN; NITRACRINE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; COVALENT BOND; CROSS LINKING; CYTOTOXICITY; DNA MODIFICATION; DNA STRAND; DRUG ACTIVITY; DRUG DNA BINDING; DRUG EFFECT; DRUG INHIBITION; METABOLIC ACTIVATION; NONHUMAN; NUCLEIC ACID RENATURATION;

EID: 0344076152     PISSN: 00282685     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. BARTOSZEK, A., DACKIEWICZ, P., SKŁADANOWSKI, A., KONOPA, J.: In vitro DNA crosslinking by Ledakrin an antitumor derivative of 1-nitro-9-aminoacridine. Chem.-Biol. Interact., 103, 1997, 141-151.
2. DARDALHON, M., AVERBECK, D.: Induction and removal of DNA interstrand cross-links in V-79 Chinese hamster cells measured by hydroxylapatite chromatography after treatments with bifunctional furocoumarins. Int. J. Radiat. Biol., 54, 1988, 1007-1020.
3. GNIAZDOWSKI, M., SZMIGIERO, L.: Nitracrine and its congeners. An overview. Gen. Pharmacol., 26, 1995, 473-481.
4. GNIAZDOWSKI, M., CERA, C.: The effects of DNA covalent adducts on in vitro transcription. Chem. Rev., 96, 1996, 619-634.
5. GNIAZDOWSKI, M., CIESIELSKA, E., SZMIGIERO, L.: Some properties of the irreversible complexes of nitracrine (Ledakrin, C-283) with polynucleotides. Chem. Biol. Interact., 34, 1981, 355-366.
6. GNIAZDOWSKI, M., CZYŻ, M., WILMAŃSKA, D., STUDZIAN, K., FRASUNEK, M., PŁUCIENNICZAK, A., SZMIGIERO, L.: Inhibition of DNA-dependent RNA synthesis by 8-methoxypsoralen. Biochim. Biophys. Acta, 950, 1988, 346-353.
7. GUIOTTO, A., RODIGHIERO, P., MANZINI, P., PASTORINI, G., BORDIN, F., BACCICHETTI, F., CARLASSARE, F., VEDALDI, D., DALL'ACQUA, F., TAMARO, M., RECCHIA, G., CRISTOFOLINI, M.: 6-Methylangelicins: A new series of potential photochemotherapeutic agents for the treatment of psoriasis. J. Med. Chem., 27, 1984, 959-967.
8. KONOPA, J., PAWLAK, J.W., PAWLAK, K.: The mode of action of cytotoxic and antitumor 1-nitroacridines. III. In vitro intranstrand cross-linking of DNA of mammalian or bacterial cells by 1-nitroacridines. Chem. Biol. Interact., 43, 1983, 175-197.
9. KONOPA, J.: Interstrand DNA cross-linking in tumor cells by 1 -nitroacridines, anthracyclines and aminoanthra-guinones. In: Molecular Aspects of Chemotherapy. Eds: Borowski, E., Shugar, D. New York, Oxford, Pergamon Press 1988, 83-94.
10. KRAWCZYK, Z.: Inhibition of RNA polymerase B activity in normal and regenerating rat liver after administration of 9-aminoacridine. Acta Biochim. Polon., 29, 1982, 259-271.
11. MARCIANI-MAGNO, S., ANTONELLO, C., BACCICHETTI, F., GIA, O., RODIGHIERO, G., PATHAK, M.A.: Photoreactive water-soluble derivatives of psoralen. Il Farmaco, 36, 1981, 13-22.
12. MARMUR, J.: A procedure for the isolation of deoxyribonucleic acid from micro-organisms. J. Mol. Biol., 3, 1961, 208-218.
13. MAZERSKA, Z., ŁUKOWICZ, J., KONOPA, J.: Antitumor activity of 1-nitro-9-aminoacridines including nitracrine against some ascitic experimental tumor. Arzneim. Forsch/Drug. Res., 40, 1990, 472-477.
14. SPLENGER, S.J., SINGER, B.: Formation of interstrand cross-links in chloroacetaldehyde-treated DNA demonstrated by ethidium bromide fluorescence. Cancer Res., 48, 1988, 4884-4886.
15. SZMIGIERO, L., STUDZIAN, K.: DNA damage and cytotoxicity of nitracrine in cultured HeLa cells. Biochim. Biophys. Acta, 1008, 1989, 339-345.
16. TOŁWINSKA-STAŃCZYK, Z., WILMAŃSKA, D., STUDZIAN, K., GNIAZDOWSKI, M.: Transcriptional template activity of covalently modified DNA. Mutat. Res., 374, 1997, 139-143.
17. WALICKA, M., SZMIGIERO, L., CIESIELSKA, E., GRODZKA, I.: Are lethal effects of nitracrine on L5178Y cell sublines associated with DNA-protein crosslinks? Biochem. Pharmacol., 46, 1993, 615-620.
18. WILMAŃSKA, D., MAŁAGOCKA, E., SZMIGIERO, L., GNIAZDOWSKI, M.: Effect of intercalating and groove-binding ligands on formation of covalent complexes between nitracrine (Ledakrin, C-283) or 8-methoxy-psoralen and DNA. Biochim. Biophys. Acta, 782, 1984, 285-294.
19. WOYNAROWSKI, J.M., MCNAMEE, H., SZMIGIERO, L., BEERMAN, A., KONOPA, J.: Induction of DNA-protein crosslinks by antitumor 1-nitro-9-aminoacridines in L1210 leukemia cells. Biochem. Pharmacol., 38, 1989, 4095-4101.