An aging-related cell surface NADH oxidase (arNOX) generates superoxide and is inhibited by coenzyme Q

Molecular and Cellular Biochemistry

Volumn 254, Issue 1-2, 2003, Pages 101-109

  Morré, Dorothy M ^a   Guo, Fenghui ^a   Morré, D James ^b  

^a PURDUE UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

Author keywords

Aging; arNOX; Atherogenesis; Coenzyme Q; NADH (hydroquinone) oxidase; Superoxide

Indexed keywords

CELL SURFACE PROTEIN; CYTOCHROME C; LIPOPROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; SUPEROXIDE DISMUTASE; UBIQUINONE;

AGED; AGING; ARTICLE; ATHEROGENESIS; CELL SURFACE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; OSCILLATION; OXIDATIVE STRESS; PROTEIN ANALYSIS; PROTEIN FAMILY; PROTEIN FUNCTION; SENSITIVITY ANALYSIS;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; AGING; CELL MEMBRANE; CYTOCHROME REDUCTASES; CYTOCHROMES C; ENDOPEPTIDASE K; HUMANS; KINETICS; MIDDLE AGED; MULTIENZYME COMPLEXES; NADH, NADPH OXIDOREDUCTASES; OSCILLOMETRY; OXIDATIVE STRESS; OXYGEN; SUPEROXIDE DISMUTASE; SUPEROXIDES; TIME FACTORS; UBIQUINONE;

EID: 0344034353     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1027301405614     Document Type: Article

References (24)

1. Butler J, Koppenol WH, Margoliash E: Kinetics and mechanism of the reduction of ferricytochrome c by the superoxide anion. J Biol Chem 257: 10747-10750, 1982
2. Chueh P-J, Morré DM, Morré DJ: A site-directed mutagenesis analysis of tNOX functional domains. Biochim Biophys Acta 1594: 74-83, 2002
3. Chueh P-J, Kim C, Cho N, Morré DM, Morré DJ: Molecular cloning and characterization of a tumor-associated, growth related, and time-keeping hydroquinone (NADH) oxidase (tNOX) of the HeLa cell surface. Biochemistry 41: 3732-3741, 2002
4. deGrey ADNJ: The Mitochondrial Free Radical Theory of Aging. R.G. Landes, Austin, TX. 1999, pp 104-110
5. Foster K, Anwar N, Pogue R, Morré DM, Keenan TW, Morré DJ: Decomposition analyses applied to a complex ultradian biorhythm: The oscillating NADH oxidase activity of plasma membranes having a potential time-keeping (clock) function. Nonlinearity Biol Toxicol Med 1: 51-70, 2003
6. Gorman A, McGowan A, Cutler TG: Role of peroxide and superoxide anion during tumor cell apoptosis. FEBS Lett 404: 27-33, 1997
7. Kelker M, Kim C, Chueh P-J, Guimont R, Morré DM, Morré DJ: Cancer isoform of a tumor-associated cell surface NADH oxidase (tNOX) has properties of a prion. Biochemistry 40: 7351-7354, 2001
8. Kishi T, Morré DM, Morré DJ: The plasma membrane NADH oxidase of HeLa cells has hydroquinone oxidase activity. Biochim Biophys Acta 1412: 66-77, 1999
9. o cells. J Biol Chem 269: 30097-30100, 1994
10. Mayo LA, Curnutte J: Kinetic microplate assay for superoxide production by neutrophils and other phagocytic cells. Meth Enzymol 186: 567-575, 1990
11. Morré DJ: NADH oxidase: A multifunctional ectoprotein of the eukaryotic cell surface. In: H. Asard, A. Bérci, R.J. Caubergs (eds). Plasma Membrane Redox Systems and their Role in Biological Stress and Disease. Kluwer Academic Publishers, Dordrecht, The Netherlands, 1998 pp 121-156
12. Morré DJ: Preferential inhibition of the plasma membrane NADH oxidase (NOX) activity by diphenyleneiodonium chloride with NADPH as donor. Antioxid Redox Signal 4: 207-212, 2002
13. Morré DJ, Chueh P-J, Lawler J, Morré DM: The sulfonylurea-inhibited NADH oxidase activity of HeLa cell plasma membranes has properties of a protein disulfide-thiol oxidoreductase with protein disulfide-thiol interchange activity. J Bioenerget Biomemb 30: 477-487, 1998
14. Morré DJ, Pogue R, Morré DM: A multifunctional ubiquinol oxidase of the external cell surface and sera. BioFactors 9: 179-187, 1999
15. Morré DM, Lenaz G, Morré DJ: Surface oxidase and oxidative stress propagation in aging. J Exptl Biol 203: 1513-1521, 2000
16. Morré DJ, Chueh P-J, Pletcher J, Tang X, Wang L-Y, Morré DM: Biochemical basis for the biological clock. Biochemistry 41: 11941-11945, 2002
17. 5 reductase as myristic acid and the complete amino acid sequence of the membrane-binding domain. J Biol Chem 259: 13349-13354, 1984
18. Sedlak D, Morré DM. Morré DJ: A drug-unresponsive and protease-resistant CNOX protein from human sera. Arch Biochem Biophys 386: 106-116, 2001
19. Smith PK, Krohn RJ, Hermanson GT, Mallia AK, Gartner FD, Provenzano MD, Fugimoto EK, Goeke NM, Olson BJ, Klenk DC: Measurement of protein using bicinchoninic acid. Anal Biochem 150: 70-76, 1985
20. 5 reductase containing both the catalytic site and an additional hydrophobic membrane-binding segment. J Biol Chem 2483: 793-799, 1973
21. 5 oxidoreductase from rat liver microsomes. Biochem J 182: 21P-22P, 1970
22. Steinberg D: Low density lipoprotein oxidation and its pathobiological significance. J Biol Chem 272: 20963-20966, 1997
23. Strittmatter P, Velick SF: A microsomal cytochrome reductase specific for diphosphopyridine nucleotide. J Biol Chem 221: 277-286, 1956
24. Strittmatter P, Velick SF: The purification and properties of microsomal cytochrome reductase. J Biol Chem 228: 785-799, 1957