Synthesis and anti-proliferative activity in vitro of new 5-(2-amino-3-pyridyl)-2-thioxo-3H-1,3,4-oxadiazole derivatives

Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry

Volumn 42, Issue 11, 2003, Pages 2846-2852

  Liszkiewicz, H ^a   Kowalska, M W ^b   Wietrzyk, J ^c   Opolski, A ^c  

^a WROCLAW MEDICAL UNIVERSITY   (Poland)

^b UNIVERSITY OF WROC AW   (Poland)

^c INSTITUTE OF IMMUNOLOGY AND EXPERIMENTAL THERAPY   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINONICOTINIC ACID HYDRAZIDE; 5 (2 AMINO 3 PYRIDYL) 2 (2 HYDROXYETHYLAMINO) 1,3,4 OXADIAZOLE; 5 (2 AMINO 3 PYRIDYL) 2 (2 PYRIDYLMETHYLAMINO) 1,3,4 OXADIAZOLE; 5 (2 AMINO 3 PYRIDYL) 2 (PYRROLIDINYL) 1,3,4 OXADIAZOLE; 5 (2 AMINO 3 PYRIDYL) 2 BENZYLAMINO 1,3,4 OXADIAZOLE; 5 (2 AMINO 3 PYRIDYL) 2 CARBAMYLMETHYLTHIO 1,3,4 OXADIAZOLE; 5 (2 AMINO 3 PYRIDYL) 2 CARBAZYLMETHYLTHIO 1,3,4 OXADIAZOLE; 5 (2 AMINO 3 PYRIDYL) 2 ETHOXYCARBONYLTHIO 1,3,4 OXADIAZOLE; 5 (2 AMINO 3 PYRIDYL) 2 HYDRAZIN 1,3,4 OXADIAZOLE; 5 (2 AMINO 3 PYRIDYL) 2 MORPHOLINETHYLAMINO 1,3,4 OXADIAZOLE; 5 (2 AMINO 3 PYRIDYL) 2 MORPHOLINOCARBAMYLMETHYLTHIO 1,3,4 OXADIAZOLE; 5 (2 AMINO 3 PYRIDYL) 2 N,N DIMETHYLCARBAMYLMETHYLTHIO 1,3,4 OXADIAZOLE; 5 (2 AMINO 3 PYRIDYL) 2 PIPERIDIN 1,3,4 OXADIAZOLE; 5 (2 AMINO 3 PYRIDYL) 2 PIPERIDINOCARBAMYLMETHYLTHIO 1,3,4 OXADIAZOLE; 5 (2 AMINO 3 PYRIDYL) 2 THIOXO 3H 1,3,4 OXADIAZOLE; BIS(BENZYLCARBAMYLMETHYL)DISULFIDE; CARBON DISULFIDE; CYTOTOXIC AGENT; NICOTINIC ACID DERIVATIVE; OXADIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL;

EID: 0344013429     PISSN: 03764699     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Liszkiewicz H, Glowiak T, Kowalska M W, Rutkowska M, Szelag A, Barczyñska J, Kȩdzierska-Goździk L, Błaszczyk F & Dziewiszek W, Polish J Chem, 73, 1999, 321.
2. Peet N P & Sunder S, J Org Chem, 40, 1975, 1909.
3. Peet N P & Sunder S, J Heterocycl Chem, 21, 1984, 1807.
4. Pearson S A, Excellet F & Harper A P, J Heterocycl Chem, 21, 1984, 1817.
5. Leiby R W, J. Heterocycl. Chem., 21, 1984, 1825.
6. Fülöp F, Simeonov M & Pihlaja K, Tetrahedron, 48, 1992, 531.
7. Nawrocka W & Sztuba B, Polish J Chem, 70, 1996, 197.
8. Takeuchi Y & Dennis N, Org Magn Reson, 7, 1975, 244.
9. de Kowalewski D G & Contreras R H, J Mol Struc, 213, 1989, 201.
10. Aranda G, Dessolin M, Golfier M & Guillerez M-G, Org Magn Reson, 18, 1982, 159.
11. Fascio M L & D'Accorso N B, J Heterocycl Chem, 32, 1995, 815.
12. Goswami B N, Kataky J C S, Baruah J N & Nath S C, J Heterocycl Chem, 21, 1984, 205.
13. Shah H P, Shah R B, Bhatt J J, Desai N C, Trivedi P W & Undavia N K, Indian J Chem, 37B, 1998, 180.
14. Saad H, Indian J Chem, 35B, 1996, 980.
15. Chande M S, Karnik A V, Mamdar A N & Damle S D, Indian J Chem, 30B, 1991, 430.
16. Ram V J I & Pandey H N, J Indian Chem Soc, 51, 1974, 634.
17. Geran R I, Greenberg N H, Macdonald M M, Schumacher A M & Abbott B J, Cancer Chemother Rep, 3, 1972, 59.
18. Skehan P, Storeng R, Scudiero D, Monks A, Mcmachon J, Vistica D, Warren J T, Bokesch H, Kenney S & Boyol M R, J Natl Cancer Inst, 82, 1990, 1107.