Effects of subchronic ifosfamide-mesna treatment on testes and semen characteristics in the rabbit

Reproductive Toxicology

Volumn 17, Issue 6, 2003, Pages 699-708

  Ypsilantis, Petros ^a   Papaioannou, Nikolaos ^b   Psalla, Dimitra ^b   Politou, Maria ^a   Pitiakoudis, Michail ^a   Simopoulos, Constantinos ^a  

^a DEMOCRITUS UNIVERSITY OF THRACE   (Greece)

^b ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

Ifosfamide; Mesna; Rabbit; Semen; Spermatogenesis; Testes

Indexed keywords

IFOSFAMIDE; MESNA; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHENOSPERMIA; BODY WEIGHT; CELL TYPE; COMPARATIVE STUDY; CONTROLLED STUDY; GENITAL SYSTEM; GERM CELL; GERM LAYER; HISTOLOGY; HISTOPATHOLOGY; LIBIDO; MALE; NEW ZEALAND; NONHUMAN; OLIGOSPERMIA; ORGAN WEIGHT; RABBIT; SEMINIFEROUS TUBULE; SEXUAL MATURATION; SPERM; SPERMATID; SPERMATOGENESIS; SPERMATOZOON ABNORMALITY; SPERMATOZOON COUNT; SPERMATOZOON MATURATION; SPERMATOZOON MOTILITY; TERATOZOOSPERMIA; TESTIS; TISSUE SECTION;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0344013414     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2003.08.003     Document Type: Article

References (23)

1. Soderstrom KO, Roytta M. Short-time effects of taxol on the seminiferous epithelium of the rat. Cell Tissue Res 1986;245(3): 591-8.
2. Oshio S, Tomomasa H, Amemiya H, Yazaki T, Mohri H, Umeda T, et al. Damaging effects of cisplatin on mouse spermatozoa. Arch Androl 1990;24(2):113-20.
3. Hakovirta H, Parvinen M, Lahdetie X. Effects of etoposide on stage-specific DNA synthesis during rat spermatogenesis. Mutat Res 1993;301(3):189-93.
4. Fuse H, Fujiuchi Y, Junicho A, Iwasaki M, Katayama T. Effect of carboplatin on rat spermatogenesis. Urol Int 1996;56(4):219-23.
5. Spano M, Bartoleschi C, Cordelli E, Leter G, Tiveron C, Pacchierotti F. Flow cytometric assessment of trophosphamide toxicity on mouse spermatogenesis. Cytometry 1996;24(2):174-80.
6. Saratsis Ph, Ypsilantis P, Tselkas K. Semen quality in dogs with transmissible venereal tumor during vincristine treatment. Theriogenology 2000;53(5):1185-92.
7. Dechant KL, Brogden RN, Pilkington T, Faulds D, Ifosfamide/mesna. A review of its antineoplastic activity, pharmacokinetic properties and therapeutic efficacy in cancer. Drugs 1991;42(3):428-67.
8. Ypsilantis P, Papaioannou N, Psalla D, Politou M, Simopoulos C. Effects of single dose administration of ifosfamide on testes and semen characteristics in the rabbit. Reprod Toxicol 2003;17(2):237-45.
9. Amann RP. Use of animal models for detecting specific alterations in reproduction. Fundam Appl Toxicol 1982;2:13-26.
10. Siu LL, Moore MJ. Use of mesna to prevent ifosfamide-induced urotoxicity. Support Care Cancer 1998;6(2):144-54.
11. Abercrombie M. Estimation of nuclear population from microtome sections. Anat Rec 1946;94:239-47.
12. Clermont Y, Morgentaler H. Quantitative study of spermatogenesis in the hypophysectomized rat. Endocrinology 1955;57:369-82.
13. Hafez ESE, Semen evaluation. In: Hafez ESE, editor. Reproduction in farm animals, 6th ed. Philadelphia: Lea & Febiger; 1993. p. 405-23.
14. Steel RGD, Torrie HH. Principles and procedures of statistics, 2nd ed. New York: McGraw-Hill; 1980.
15. Morton D. The use of rabbits in male reproductive toxicology. Environ Health Perspect 1988;77:5-9.
16. McGrady AV. Effects of physiologic stress on male reproduction, a review. Arch Androl 1984;13:1-7.
17. Ehling UH, Favor J, Neuhäuser-Klaus A, Adler ID. Induction of specific-locus and dominant lethal mutations in male mice by ifosfamide (Holoxan). Genet Res Camb 1998;72:177-83.
18. Vigil P, Bustos-Obregon E. Alkylating agents and mouse spermatogenesis: effects of a single dose of cyclophosphamide. Andrologia 1985;17(3):276-82.
19. Feldman EC, Nelson RW. Canine and feline endocrinology and reproduction. Philadelphia: WB Saunders Co.; 1996. p. 730.
20. Quinto I, De Marinis E, De Dominicis G, Della Morte R, Staiano N. Induction of sperm abnormalities in mice by ifosfamide and trofosfamide. Mutation Res 1988;201:113-6.
21. Cranz C, Brun B, Clavert A. Effect of short-term cyclophosphamide administration on rabbit sperm. CR Seances Soc Biol Fil 1976;170(6):1289-93.
22. Lu CC, Meistrich ML. Cytotoxic effects of chemotherapeutic drugs on mouse testis cells. Cancer Res 1979;39:3575-82.
23. Meistrich ML. Quantitative correlation between testicular stem cell survival sperm production and fertility in the mouse after treatment with different cytotoxic agents. J Androl 1982;3:58-68.