Understanding the Physical Stability of Freeze Dried Dosage Forms from the Glass Transition Temperature of the Amorphous Components

Journal of Pharmaceutical Sciences

Volumn 92, Issue 12, 2003, Pages 2495-2501

  Fitzpatrick, Shaun ^a   Saklatvala, Robert ^a  

^a Merck Sharp & Dohme Limited   (United Kingdom)

Author keywords

Freeze drying; Gelatin; Glass transition temperature; Physical stability

Indexed keywords

CITRIC ACID; EXCIPIENT; GELATIN; OLANZAPINE;

ARTICLE; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM; DRUG STABILITY; GLASS TRANSITION TEMPERATURE; ISOTHERM; MOISTURE; STORAGE TEMPERATURE;

EID: 0344012508     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.10474     Document Type: Article

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