Association of Inflammation Markers with Impaired Insulin Sensitivity and Coagulative Activation in Obese Healthy Women

Journal of Clinical Endocrinology and Metabolism

Volumn 88, Issue 11, 2003, Pages 5321-5326

  Romano, Mario ^a   Guagnano, Maria Teresa ^a   Pacini, Giovanni ^b   Vigneri, Sergio ^c   Falco, Angela ^a   Marinopiccoli, Marina ^a   Manigrasso, Maria Rosaria ^a   Basili, Stefania ^d   Davì, Giovanni ^a  

^a UNIVERSITY OF CHIETI   (Italy)

^b Inst of Syst Sci and Biomed Eng   (Italy)

^c UNIVERSITY OF PALERMO   (Italy)

^d SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 7; BLOOD CLOTTING FACTOR 7A; C REACTIVE PROTEIN; INSULIN; PLASMINOGEN ACTIVATOR INHIBITOR 1; PLASMINOGEN ACTIVATOR INHIBITOR 2; PROTHROMBIN; THROMBIN; TRANSFORMING GROWTH FACTOR BETA1;

ADULT; ARTICLE; BLOOD CLOTTING; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE MARKER; FEMALE; HUMAN; IN VIVO STUDY; INFLAMMATION; INSULIN RESISTANCE; INSULIN SENSITIVITY; MULTIPLE REGRESSION; OBESITY; PRIORITY JOURNAL;

ADULT; BIOLOGICAL MARKERS; BLOOD COAGULATION; C-REACTIVE PROTEIN; FACTOR VIIA; FEMALE; HUMANS; INSULIN RESISTANCE; MIDDLE AGED; OBESITY; PEPTIDE FRAGMENTS; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN PRECURSORS; PROTHROMBIN; THROMBIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 0344011158     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2003-030508     Document Type: Article

References (31)

1. Festa A, D'Agostino Jr R, Howard G, Mykkanen L, Tracy RP, Haffner SM 2000 Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS). Circulation 102: 42-47
2. Kuller LH, Tracy RP 2000 The role of inflammation in cardiovascular disease. Arterioscler Thromb Vasc Biol 20:901
3. Yudkin JS 1999 Abnormalities of coagulation and fibrinolysis in insulin resistance: evidence for a common antecedent? Diabetes Care 22:25-30
4. Yudkin JS, Stehouwer CD, Emeis JJ, Coppack SW 1999 C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction. A potential role for cytokines originating from adipose tissue? Arterioscler Thromb Vasc Biol 19:972-978
5. Hotamisligil GS, Arner P, Atkinson RL, Spiegelman BM 1997 Differential regulation of the p80 tumor necrosis factor receptor in human obesity and insulin resistance. Diabetes 46:451-455
6. Juhan-Vague I, Thompson SG, Jespersen J 1993 Involvement of the hemostatic system in the insulin resistance syndrome: a study of 1500 patients with angina pectoris: the ECAT Angina Pectoris Study Group. Arterioscler Thromb 13:1865-1873
7. Festa A, D'Agostino Jr R, Mykkanen L, Tracy RP, Zaccaro DJ, Hales CM, Haffner SM 1999 Relative contribution of insulin and its precursors to fibrinogen and PAI-1 in a large population with different states of glucose tolerance. The Insulin Resistance Atherosclerosis Study (IRAS). Arterioscler Thromb Vasc Biol 19:562-568
8. Samad F, Loskutoff DJ 1999 Hemostatic gene expression and vascular disease in obesity: insights from studies of genetically obese mice. Thromb Haemost 82:742-747
9. Morange PE, Alessi MC, Verdier M, Casanova D, Magalon G, Juhan-Vague I 1999 PAI-1 produced ex vivo by human adipose tissue is relevant to PAI-1 blood level. Arterioscler Thromb Vase Biol 19:1361-1365
10. Samad F, Pandey M, Loskutoff DJ 1998 Tissue factor gene expression in the adipose tissues of obese mice. Proc Natl Acad Sci USA 95:7591-7596
11. Samad F, Yamamoto K, Pandey M, Loskutoff DJ 1997 Elevated expression of transforming growth factor-β in adipose tissue from obese mice. Mol Med 3:37-48
12. Chen YQ, Sloan-Lancaster J, Berg DT, Richardson MA, Grinnell B, Tseng-Crank J 2001 Differential mechanisms of plasminogen activator inhibitor-1 gene activation by transforming growth factor-β and tumor necrosis factor-α in endothelial cells. Thromb Haemost 86:1563-1572
13. National Diabetes Data Group 1979 Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes 28:1039-1057
14. World Health Organization 1998 Obesity: Preventing and managing the global epidemic. Report on a WHO consultation on obesity. WHO/NUT/ NCD/98.1. Geneva: World Health Organization, 1997
15. Segal KR, Van Loan M, Fitzgerald PI, Hodgdon JA, Van Itallie TB 1988 Lean body mass estimation by bioelectrical impedance analysis: a four-site cross-validation study. Am J Clin Nutr 47:7-14
16. Steil GM, Volund A, Kahn SE, Bergman RN 1993 Reduced sample number for calculation of insulin sensitivity and glucose effectiveness from the minimal model. Diabetes 42:250-256
17. Davì G, Romano M, Mezzetti A, Procopio A, Iacobelli S, Antidormi T, Bucciarelli T, Alessandrini P, Cuccurullo F, Bittolo Bon G 1998 Increased levels of soluble P-selectin in hypercholesterolemic patients. Circulation 97: 953-957
18. Pacini G, Bergman RN 1986 MINMOD: a computer program to calculate insulin sensitivity and pancreatic responsivity from the frequently sampled intravenous glucose tolerance test. Comput Methods Programs Biomed 23: 113-122
19. Bergman RN 1989 Toward physiological understanding of glucose tolerance. Minimal model approach. Diabetes 38:1512-1527
20. Best JD, Kahn SE, Ader M, Watanabe RM, Ni TC, Bergman RN 1996 Role of glucose effectiveness in the determination of glucose tolerance. Diabetes Care 19:1018-1030
21. Gibaldi M, Perrier D 1982 Pharmacokinetics. 2nd ed. New York: Dekker
22. Kahn SE, Prigeon RL, McCulloch DK, Boyko EJ, Bergman RN, Schwartz MW, Neifing JL, Ward WK, Beard JC, Palmer JP, Porte Jr D 1993 Quantification of the relationship between insulin sensitivity and β-cell function in human subjects. Evidence for a hyperbolic function. Diabetes 42:1663-1672
23. Kautzky-Willer A, Krssak M, Winzer C, Pacini G, Tura A, Farhan S, Wagner O, Brabant G, Horn R, Stingl H, Schneider B, Waldhausl W, Roden M 2003 Increased intramyocellular lipid concentration identifies impaired glucose metabolism in women with previous gestational diabetes. Diabetes 52:244-251
24. Bergman RN 1997 The minimal model approach and determinants of glucose tolerance. Baton Rouge, LA: LSU Press
25. Bergman RN, Prager R, Volund A, Olefsky JM 1987 Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp. J Clin Invest 79:790-800
26. Hak AE, Stehouwer CD, Bots ML, Polderman KH, Schalkwijk CG, Westendorp IC, Hofman A, Witteman JC 1999 Associations of C-reactive protein with measures of obesity, insulin resistance, and subclinical atherosclerosis in healthy, middle-aged women. Arterioscler Thromb Vasc Biol 19:1986-1991
27. Abbasi F, McLaughlin T, Lamendola C, Lipinska I, Tofler G, Reaven GM 1999 Comparison of plasminogen activator inhibitor-1 concentration in insulin-resistant versus insulin-sensitive healthy women. Arterioscler Thromb Vasc Biol 19:2818-2821
28. Pfeiffer A, Middelberg-Bisping K, Drewes C, Schatz H 1996 Elevated plasma levels of transforming growth factor-β1 in NIDDM. Diabetes Care 19:1113-1117
29. Li B, Khanna A, Sharma V, Singh T, Suthanthiran M, August P 1999 TGF-β1 DNA polymorphisms, protein levels, and blood pressure. Hypertension 33: 271-275
30. Porreca E, Di Febbo C, Mincione G, Reale M, Baccante G, Guglielmi MD, Cuccurullo F, Colletta G 1997 Increased transforming growth factor-β production and gene expression by peripheral blood monocytes of hypertensive patients. Hypertension 30:134-139
31. Blobe GC, Schiemann WP, Lodish HF 2000 Role of transforming growth factor-β in human disease. N Engl J Med 342:1350-1358