Carbon dioxide: A "waste product" with potential therapeutic utilities in critical care

Critical Care Medicine

Volumn 31, Issue 11, 2003, Pages 2705-2707

  Torbati, Dan ^a  

^a MIAMI CHILDREN'S HOSPITAL   (United States)

Author keywords

Acid base balance; Hypercapnia; Hypocapnia; Lung injury; Mechanical ventilation; Permissive hypercapnia; Therapeutic hypercapnia

Indexed keywords

CARBON DIOXIDE;

ANESTHESIA INDUCTION; ARTERIAL CARBON DIOXIDE TENSION; EDITORIAL; HUMAN; HYPERCAPNIA; HYPOCAPNIA; INTRACRANIAL HYPERTENSION; LUNG INJURY; LUNG VENTILATION PERFUSION RATIO; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RESPIRATORY ACIDOSIS;

CARBON DIOXIDE; CRITICAL CARE; HUMANS; HYPERCAPNIA; RESPIRATION, ARTIFICIAL; RESPIRATORY DISTRESS SYNDROME, ADULT;

EID: 0344011016     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000089943.05031.B3     Document Type: Editorial

References (18)

1. Laffey JG, Kavanagh BP: Biological effects of hypercapnia. Intensive Care Med 2000; 26: 133-138
2. Laffey JK, Kavanagh BP: Carbon dioxide and the critically ill - Too little of a good thing? Lancet 1999; 354:1283-1286
3. Laffey JG, Kavanagh BP: Hypocapnia. N Engl J Med 2002; 347:43-53
4. Laffey JG, Engelberts D, Duggan M, et al: Carbon dioxide attenuates pulmonary impairment resulting from hyperventilation. Crit Care Med 2003; 31:2634-2640
5. Hickling KG: Permissive hypercapnia. Respir Care Clin N Am 2002; 8:155-169
6. Thompson BT, Hayden D, Matthay MA, et al: Clinician's approaches to mechanical ventilation in acute lung injury and ARDS. Chest 2001; 120:1622-1627
7. Hess DR, Gillette MA: Conference proceedings. Tracheal gas insufflation and related techniques to introduce gas flow into trachea. Respir Care 2001; 46:119-129
8. Epstein SK, Singh N: Respiratory acidosis. Respir Care 2001; 46:366-383
9. Kavanagh B: Normocapnia vs hypercapnia. Minerva Anestesiol 2002; 68:346-350
10. Swenson ER, Robertson HT, Hlastala P: Effects of inspired carbon dioxide on ventilation-perfusion matching in normoxia, hypoxia, and hyperoxia. Am J Respir Crit Care Med 1994; 149:1563-1569
11. Torbati D, Mangino MJ, Garcia E, et al: Acute hypercapnia increases the oxygen-carrying capacity of the blood in ventilated dogs. Crit Care Med 1998; 26:1863-1867
12. Ramirez J, Totapally BR, Hon E, et al: Oxygen-carrying capacity during 10 hours of hypercapnia in ventilated dogs. Crit Care Med 2000; 28:1918-1923
13. Torbati D, Totapally BR, Camacho MT, et al: Experimental critical care in ventilated rats: Effect of hypercapnia on arterial oxygen-carrying capacity. J Crit Care 1999; 14: 191-197
14. Vannucci RC, Towfighi J, Heitjan DF, et al: Carbon dioxide protects the perinatal brain from hypoxic-ischemic damage: An experimental study in the immature rat. Pediatrics 1995; 95:868-874
15. Laffey JG, Tanaka M, Engelberts D, et al: Therapeutic hypercapnia reduces pulmonary and systemic injury following in vivo reperfusion. Am J Respir Crit Care Med 2000; 162:2287-2294
16. Broccard AF, Hotchkiss JR, Vannay C, et al: Protective effects of hypercapnic acidosis on ventilator induced lung injury. Am J Respir Crit Care Med 2001; 164:802-806
17. Sinclair SE, Kregenow DA, Lamm WJE, et al: Hypercapnic acidosis is protective in an in vivo model of ventilator-induced lung injury. Am J Respir Crit Care Med 2002; 166: 403-408
18. Rotta AT, Gunnarsson B, Fuhrman BP, et al: Comparison of lung protective ventilation strategies in a rabbit model of acute lung injury. Crit Care Med 2001; 29:2176-2184