Colonization with antibiotic-resistant Gram-negative bacilli in the neonatal intensive care unit

Minerva Pediatrica

Volumn 55, Issue 5, 2003, Pages 385-393

  Toltzis, P ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Antibiotics; Gram negative bacterial infections; Infant, newborn; Intensive care units

Indexed keywords

AMPICILLIN; CEPHALOSPORIN; PENICILLIN G;

ANTIBIOTIC RESISTANCE; BACTERIAL COLONIZATION; CLINICAL TRIAL; DISEASE PREDISPOSITION; DISEASE SEVERITY; DISEASE TRANSMISSION; ECOLOGY; ENTEROBACTER; GASTROINTESTINAL INFECTION; GRAM NEGATIVE BACTERIUM; HEALTH CARE PERSONNEL; HOSPITAL ADMISSION; HUMAN; INCIDENCE; INTENSIVE CARE; KLEBSIELLA; PROPHYLAXIS; REVIEW; RHINOPHARYNGITIS; SERRATIA;

AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; CEPHALOSPORINS; CROSS INFECTION; DISEASE OUTBREAKS; DRUG RESISTANCE, BACTERIAL; FEMALE; GRAM-NEGATIVE BACTERIA; GRAM-NEGATIVE BACTERIAL INFECTIONS; HUMANS; INFANT, NEWBORN; INTENSIVE CARE UNITS, NEONATAL; ITALY; MALE; PREGNANCY;

EID: 0344010160     PISSN: 00264946     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (68)

1. Shah SS, Ehrenkranz RA, Gallagher PG. Increasing incidence of Gram-negative rod bacteremia in a newborn intensive care unit. Pediatr Infect Dis J 1999;18:591-5.
2. Centers for Disease Control and Prevention. Prevention of perinatal Group B streptococcal disease. Morb Mort Weekly Report 2002;51:1-22.
3. Baltimore RS, Huie SM, Meek JI, Schuchat A, O'Brien KL. Early-onset neonatal sepsis in the era of group B streptococcal prevention. Pediatrics 2001;108:1094-8.
4. Stoll BJ, Hansen N, Fanaroff AA, Wright LL, Carlo WA, Ehrenkranz RA et al. Changes in pathogens causing early-onset sepsis in very-low-birth- weight infants. N Engl J Med 2002;347:240-7.
5. Hyde TB, Hilger TM, Reingold A, Farley MM, O'Brien KL, Schuchat A. Trends in incidence and antimicrobial resistance of early-onset sepsis: population-based surveillance in San Francisco and Atlanta. Pediatrics 2002;110:690-5.
6. Schuchat A, Zywicki SS, Dinsmoor MJ, Mercer B, Romaguera J, O'Sullivan MJ et al. Risk factors and opportunities for prevention of early-onset neonatal sepsis: a multicenter case-control study. Pediatrics 2000;105:21-6.
7. Sohn AH, Garrett DO, Sinkowitz-Cochran RL, Grohskopf LA, Levine GL, Stover BH et al. Prevalence of nosocomial infections in neonatal intensive care unit patients: results from the first national point-prevalence survey. J Pediatr 2001;139:821-7.
8. Gaynes RP, Edwards JR, Jarvis WR, Culver DH, Tolson JS, Martone WJ. Nosocomial infections among neonates in high-risk nurseries in the United States. National Nosocomial Infections Surveillance System. Pediatrics 1996;98:357-61.
9. Stoll BJ, Hansen N, Fanaroff AA, Wright LL, Carlo WA, Ehronkranz RA et al. Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network. Pediatrics 2002;110:285-91.
10. Bromiker R, Arad I, Peleg O, Preminger A, Engelhard D. Neonatal bacteremia: patterns of antibiotic resistance. Infect Control Hosp Epidemiol 2001;22:767-70.
11. Nambiar S, Singh N. Change in epidemiology of health care-associated infections in a neonatal intensive care unit. Pediatr Infect Dis J 2002;21:839-42.
12. Singh N, Patel KM, Leger MM, Short B, Sprague BM, Kaln N et al. Risk of resistant infections with Enterobacteriaceae in hospitalized neonates. Pediatr Infect Dis J 2002;21:1029-33.
13. Goldmann DA. Bacterial colonization and infection in the neonate. Am J Med 1981;70:417-22.
14. Finelli L, Livengood JR, Saiman L. Surveillance of pharyngeal colonization: detection and control of serious bacterial illness in low birth weight infants. Pediatr Infect Dis J 1994;13:854-9.
15. Eriksson M, Melen B, Myrback KE, Winbladh B, Zetterstrom R. Bacterial colonization of newborn infants in a neonatal intensive care unit. Acta Paediatr Scand 1982;71:779-83.
16. Leonard EM, van Saene HK, Shears P, Walker J, Tam PK. Pathogenesis of colonization and infection in a neonatal surgical unit. Crit Care Med 1990;18:264-9.
17. Almuneef MA, Baltimore RS, Farrel PA, Reagan-Cirincione P, Dembry LM. Molecular typing demonstrating transmission of Gram-negative rods in a neonatal intensive care unit in the absence of a recognized epidemic. Clin Infect Dis 2001;32:220-7.
18. Benno Y, Sawada K, Mitsuoka T. The intestinal microflora of infants: composition of fecal flora in breastfed and bottle-fed infants. Microbiol Immunol 1984;28:975-86.
19. Balmer SE, Scott PH, Wharton BA. Diet and faecal flora in the newborn: lactoferrin. Arch Dis Child 1989;64:1685-90.
20. Balmer SE, Wharton BA. Diet and faecal flora in the newborn: breast milk and infant formula. Arch Dis Child 1989;64:1672-7.
21. Lundequist B, Nord CE, Winberg J. The composition of the faecal microflora in breastfed and bottle fed infants from birth to eight weeks. Acta Paediatr Scand 1985;74:45-51.
22. Hokama T, Imamura T. Members of the throat microflora among infants with different feeding methods. J Trop Pediatr 1998;44:84-6.
23. Goldmann DA, Leclair J, Macone A. Bacterial colonization of neonates admitted to an intensive care environment. J Pediatr 1978;93:288-93.
24. Tullus K, Fryklund B, Berglund B, Kallenius G, Burman LG. Influence of age on faecal carriage of P-fimbriated Escherichia coli and other Gram-negative bacteria in hospitalized neonates. J Hosp Infect 1988;11:349-56.
25. Savey A, Fleurette J, Salle BL. An analysis of the microbial flora of premature neonates. J Hosp Infect 1992;21:275-89.
26. Toltzis P, Dul MJ, Hoyen C, Salvator A, Walsh M, Zetts L et al. Molecular epidemiology of antibiotic-resistant gram-negative bacilli in a neonatal intensive care unit during a nonoutbreak period. Pediatrics 2001;108:1143-8.
27. Casewell M, Phillips I. Hands as route of transmission for Klebsiella species. Br Med J 1977;2:1315-7.
28. Knittle MA, Eitzman DV, Baer H. Role of hand contamination of personnel in the epidemiology of Gram-negative nosocomial infections. J Pediatr 1975;86:433-7.
29. Guenthner SH, Hendley JO, Wenzel RP. Gram-negative bacilli as nontransient flora on the hands of hospital personnel. J Clin Microbiol 1987;25:488-90.
30. Sanderson PJ, Weissler S. Recovery of coliforms from the hands of nurses and patients: activities leading to contamination. J Hosp Infect 1992;21:85-93.
31. Pittet D, Dharan S, Touveneau S, Sauvan V, Perneger TV. Bacterial contamination of the hands of hospital staff during routine patient care. Arch Intern Med 1999;159:821-6.
32. Pittet D, Hugonnet S, Harbarth S, Mourouga P, Sauvan V, Tauvenlau S et al. Effectiveness of a hospital-wide programme to improve compliance with hand hygiene. Infection Control Programme. Lancet 2000;356:1307-12. [Erratum in: Lancet 2000;356:2196].
33. Pittet D, Hugonnet S, Harbarth S, Mourouga P, Sauvan V, Tauvenlau S et al. Effectiveness of a hospital-wide programme to improve compliance with hand hygiene. Infection Control Programme. Lancet 2000;356:1307-12. [Erratum in: Lancet 2000;356:2196].
34. Hedderwick SA, McNeil SA, Lyons MJ, Kauffman CA. Pathogenic organisms associated with artificial fingernails worn by healthcare workers. Infect Control Hosp Epidemiol 2000;21:505-9.
35. Foca M, Jakob K, Whittier S, Della Latta P, Factor S, Rubenstein D et al. Endemic Pseudomonas aeruginosa infection in a neonatal intensive care unit. N Engl J Med 2000;343:695-700.
36. Moolenaar RL, Crutcher JM, San Joaquin VH, Sewell LV, Hutwagner LC, Carson LA et al. A prolonged outbreak of Pseudomonas aeruginosa in a neonatal intensive care unit: did staff fingernails play a role in disease transmission? Infect Control Hosp Epidemiol 2000;21:80-5.
37. Bryan CS, John JF, Pai MS, Austin TL. Gentamicin vs cefotaxime for therapy of neonatal sepsis: relationship to drug resistance. Am J Dis Child 1985;139:1086-9.
38. Tullus K, Burman LG. Ecological impact of ampicillin and cefuroxime in neonatal units. Lancet 1989;1:1405-7.
39. Tullus K, Berglund B, Fryklund B, Kuhn I, Burman LG. Influence of antibiotic therapy on faecal carriage of P-fimbriated Escherichia coli and other Gram-negative bacteria in neonates. J Antimicrob Chemother 1988;22:563-8.
40. Tullus K, Berglund B, Fryklund B, Kuhn I, Burman LG. Epidemiology of fecal strains of the family Enterobacteriaceae in 22 neonatal wards and influence of antibiotic policy. J Clin Microbiol 1988;26:1166-70.
41. Krediet TG, Fleer A, Gerards LJ. Development of resistance to aminoglycosides among coagulase-negative staphylococci and enterobacteriaceae in a neonatal intensive care unit. J Hosp Infect 1993;24:39-46.
42. Chow JW, Fine MJ, Shlaes DM, Quinn JP, Hooper DC, Johnson MP et al. Enterobacter bacteremia: clinical features and emergence of antibiotic resistance during therapy. Ann Intern Med 1991;115:585-90.
43. de Man P, Verhoeven BA, Verbrugh HA, Vos MC, van den Anker JN. An antibiotic policy to prevent emergence of resistant bacilli. Lancet 2000;355:973-8.
44. Toltzis P, Blumer JL. Antibiotic-resistant Gram-negative bacteria in the critical care setting. Pediatr Clin North Am 1995;42:687-702.
45. Kartali G, Tzelepi E, Pournaras S, Kontopoulou C, Kontos F, Sofianou D et al. Outbreak of infections caused by Enterobacter cloacae producing the integron-associated beta-lactamase IBC-1 in a neonatal intensive care unit of a Greek hospital. Antimicrob Agents Chemother 2002;46:1577-80.
46. v Dijk Y, Bik EM, Hochstenbach-Vernooij S, v d Vlist GJ, Savelkone PH, Kaen JA et al. Management of an outbreak of Enterobacter cloacae in a neonatal unit using simple preventive measures. J Hosp Infect 2002;51:21-6.
47. van Acker J, de Smet F, Muyldermans G, Bougatef A, Naessens A, Lauwers S. Outbreak of necrotizing enterocolitis associated with Enterobacter sakazakii in powdered milk formula. J Clin Microbiol 2001;39:293-7.
48. van den Berg RW, Claahsen HL, Niessen M, Muytjens HL, Liem K, Voss A. Enterobacter cloacae outbreak in the NICU related to disinfected thermometers. J Hosp Infect 2000;45:29-34.
49. Tresoldi AT, Padoveze MC, Trabasso P, Veiga JF, Marba ST, von Nowakonski A et al. Enterobacter cloacae sepsis outbreak in a newborn unit caused by contaminated total parenteral nutrition solution. Am J Infect Control 2000;28:258-61.
50. Yu WL, Cheng HS, Lin HC, Peng CT, Tsai CH. Outbreak investigation of nosocomial Enterobacter cloacae bacteraemia in a neonatal intensive care unit. Scand J Infect Dis 2000;32:293-8.
51. Liu SC, Leu HS, Yen MY, Lee PI, Chou MC. Study of an outbreak of Enterobacter cloacae sepsis in a neonatal intensive care unit: the application of epidemiologic chromosome profiling by pulsed-field gel electrophoresis. Am J Infect Control 2002;30:381-5.
52. Fernandez-Baca V, Ballesteros F, Hervas JA, Villalon P, Dominguez MA, Benedi VJ et al. Molecular epidemiological typing of Enterobacter cloacae isolates from a neonatal intensive care unit: three-year prospective study. J Hosp Infect 2001;49:173-82.
53. Peters SM, Bryan J, Cole MF. Enterobacterial repetitive intergenic consensus polymerase chain reaction typing of isolates of Enterobacter cloacae from an outbreak of infection in a neonatal intensive care unit. Am J Infect Control 2000;28:123-9.
54. Cotton MF, Wasserman E, Pieper CH, Theron DC, van Tubbergh D, Campbell G et al. Invasive disease due to extended spectrum beta-lactamase-producing Klebsiella pneumoniae in a neonatal unit: the possible role of cockroaches. J Hosp Infect 2000;44:13-7.
55. Gonzalez-Vertiz A, Alcantar-Curiel D, Cuauhtli M, Daza C, Gayosso C, Solache G et al. Multiresistant extended-spectrum beta-lactamase-producing Klebsiella pneumoniae causing an outbreak of nosocomial blood-stream infection. Infect Control Hosp Epidemiol 2001;22:723-5.
56. Berthelot P, Grattard F, Patural H, Ros A, Jelassi-Saoudin H, Pozzetto B et al. Nosocomial colonization of premature babies with Klebsiella oxytoca: probable role of enteral feeding procedure in transmission and control of the outbreak with the use of gloves. Infect Control Hosp Epidemiol 2001;22:148-51.
57. Jeong SH, Kim WM, Chang CL, Kim JM, Lee K, Chong V et al. Neonatal intensive care unit outbreak caused by a strain of Klebsiella oxytoca resistant to aztreonam due to overproduction of chromosomal beta-lactamase. J Hosp Infect 2001;48:281-8.
58. Lebessi E, Dellagrammaticas H, Tassios PT, Tzouvelekis LS, Ioannidou S, Foustoukou M et al. Extended-spectrum beta-lactamase-producing Klebsiella pneumoniae in a neonatal intensive care unit in the high-prevalence area of Athens, Greece. J Clin Microbiol 2002;40:799-804.
59. Macrae MB, Shannon KP, Rayner DM, Kaiser AM, Hoffman PN, French GL. A simultaneous outbreak on a neonatal unit of two strains of multiply antibiotic resistant Klebsiella pneumoniae controllable only by ward closure. J Hosp Infect 2001;49:183-92.
60. Otman J, Cavassin ED, Perugini ME, Vidotto MC. An outbreak of extended-spectrum beta-lactamase-producing Klebsiella species in a neonatal intensive care unit in Brazil. Infect Control Hosp Epidemiol 2002;23:8-9.
61. Jang TN, Fung CP, Yang TL, Shen SH, Huang CS, Lee SH. Use of pulsed-field gel electrophoresis to investigate an outbreak of Serratia marcescens infection in a neonatal intensive care unit. J Hosp Infect 2001;48:13-9.
62. Jones BL, Gorman LJ, Simpson J, Curtan ET, McNamee S, Lucas C et al. An outbreak of Serratia marcescens in two neonatal intensive care units. J Hosp Infect 2000;46:314-9.
63. Assadian O, Berger A, Aspock C, Mustafa S, Kohlhauser C, Hirschl AM. Nosocomial outbreak of Serratia marcescens in a neonatal intensive care unit. Infect Control Hosp Epidemiol 2002;23:457-61.
64. Fleisch F, Zimmermann-Baer U, Zbinden R, Bischoff G, Arlettaz R, Waldvogel K et al. Three consecutive outbreaks of Serratia marcescens in a neonatal intensive care unit. Clin Infect Dis 2002;34:767-73.
65. Prasad GA, Jones PG, Michaels J, Garland JS, Shivpuri CR. Outbreak of Serratia marcescens infection in a neonatal intensive care unit. Infect Control Hosp Epidemiol 2001;22:303-5.
66. Villari P, Crispino M, Salvadori A, Scarcella A. Molecular epidemiology of an outbreak of Serratia marcescens in a neonatal intensive care unit. Infect Control Hosp Epidemiol 2001;22:630-4.
67. Pillay T, Pillay DG, Adhikari M, Pillay A, Sturm AW. An outbreak of neonatal infection with Acinetobacter linked to contaminated suction catheters. J Hosp Infect 1999;43:299-304.
68. Centers for Disease Control and Prevention. Enterobacter sakazakii infections associated with the use of powdered infant formula-Tennessee, 2001. MMWR Morb Mortal Wkly Rep 2002;51:297-300.