Enzymatic resolution of (±)-1-ferrocenylethylamine

Tetrahedron Asymmetry

Volumn 11, Issue 5, 1999, Pages 1047-1050

  Iglesias, Luis E ^a   Rebolledo, Francisca ^a   Gotor, Vicente ^a  

^a UNIVERSITY OF OVIEDO   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

FERROCENE; FERROCENYLETHYLAMINE; FUNGAL ENZYME; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG;

ACETYLATION; BIOTRANSFORMATION; CANDIDA ANTARCTICA; CATALYSIS; CONTROLLED STUDY; PRIORITY JOURNAL; SHORT SURVEY; STEREOCHEMISTRY; TECHNIQUE;

EID: 0344002701     PISSN: 09574166     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0957-4166(00)00036-7     Document Type: Article

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18. In a typical procedure, CAL-B (75 mg) was added to a solution of (±)-1 (2.5 mmol) in 2a (8 mL) and the resulting mixture was shaken at 28°C and 200 rpm. When reaction times indicated in Table 1 were reached the lipase was filtered off, washed with dichloromethane and the resulting filtrate subjected to the work-up depicted in Scheme 1.
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20. 2: C, 66.11; H, 5.83; N, 3.86. Found: C, 65.73; H, 6.14; N, 3.79.
21. R 19.09 min.
22. D + 13.5 (c 1.2, EtOH) 88% ee} differed from reported data (El-Shihi, T.; Siglmuller, F.; Herrmann, R.; Carvalho, M. F.; Pombeiro, A. J. L. J. Organomet. Chem. 1987, 335, 239), its configuration was confirmed through the specific rotation of (R)-5.