Comparison of the effects of antiprogestins RU38486, ZK98299 and ORG31710 on periovulatory hypophysial, ovarian and adrenal hormone secretion in the rat

Journal of Endocrinological Investigation

Volumn 23, Issue 3, 2000, Pages 151-157

  Sánchez Criado, José E ^b   Tebar M ^a   Bellido, C ^c   De Jong, F H ^a  

^a ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^b UNIVERSITY OF CÓRDOBA   (Spain)

^c NONE

Author keywords

Antiprogestins; Estrous cycle; FSH; Inhibin; LH

Indexed keywords

11BETA [4 (DIMETHYLAMINO)PHENYL] 4',5' DIHYDRO 6BETA METHYLSPIRO[ESTRA 4,9 DIENE 17BETA,2'(3'H) FURAN] 3 ONE; ANTIGESTAGEN; CORTICOSTERONE; ESTRADIOL; FOLLITROPIN; INHIBIN A; LUTEINIZING HORMONE; MIFEPRISTONE; ONAPRISTONE; PROGESTERONE;

ADRENAL GLAND; ANIMAL EXPERIMENT; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CORTICOSTEROID RELEASE; DRUG EFFECT; ESTRUS; ESTRUS CYCLE; FEMALE; FOLLITROPIN RELEASE; HORMONE RELEASE; HYPOPHYSIS; LUTEINIZING HORMONE RELEASE; NONHUMAN; OVARY; PROESTRUS; PROGESTERONE RELEASE; RAT; RECEPTOR BLOCKING;

EID: 0344002693     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03343698     Document Type: Article

References (43)

1. Freeman M.E. The ovarian cycle of the rat. In: Knobil E., Neill J. (Eds.), The Physiology of Reproduction. Raven Press Ltd., New York, 1988, vol. 2, p. 1893.
2. Grady R.R., Schwartz N.B. Role of gonadal feedback in the differential regulation of LH and FSH. In: Franchimont P., Channing C.P. (Eds.), Intragonadal Regulation of Reproduction. Academic Press, London, 1981, p. 377.
3. Chappel S. Factors that regulate follicle stimulating hormone biosynthesis and secretion. In: Burger H.G., de Kretser D.M., Findlay J.K., Igarashi M. (Eds.), Inhibin-Non-Steroidal Regulation of Follicle Stimulating Hormone Secretion. Raven Press, New York, 1987, p. 1.
4. Baulieu E.E. Contragestion and other clinical applications of RU486, an antiprogestagen at the receptor. Science 1989, 245: 1351-1357.
5. Rao I.M., Mahesh V.B. Role of progesterone in the modulation of the preovulatory surge of gonadotropins and ovulation in the pregnant mare's serum gonadotropin primed immature rat and the adult rat. Biol. Reprod. 1986, 35: 1154-1161.
6. Knox K.L., Ringstrom S.J., Schwartz N.B. RU486 Block the effects of inhibin or luteinizing hormone on the second follicle-stimulating hormone surge. Endocrinology 1993, 133: 277-283.
7. Tébar M., Bellido C., Sánchez-Criado J.E. Luteinizing hormone (LH) and corticosterone in proestrous afternoon restore the follicle-stimulating hormone secretion at early estrus in adrenalectomized LH-releasing hormone antagonist-treated rats. Biol. Reprod. 1995, 52: 63-67.
8. Tébar M., Bellido C., Sánchez-Criado J.E. Evidence for a permissive effect of extraovarian steroids on the release of FSH at early estrus in rats lacking inhibin secretion or action. Neuroendocrinol. Let. 1995, 17: 21-27.
9. Sánchez-Criado J.E., Hernandez G., Bellido C., Gonzalez D., Tébar M., Diaz-Cruz A., Alonso R. Periovulatory LHRH, LH and FSH secretion in cyclic rats treated with RU486: effects of exogenous LHRH and LHRH antagonist on LH and FSH secretion at early oestrus. J. Endocrinol. 1994, 141: 7-14.
10. Szabo M., Knox K.L., Ringstrom S.J., Perlyn C.A., Sutandi S., Schwartz N.B. Mechanism of the inhibitory action of RU486 on the secondary follicle-stimulating hormone surge. Endocrinology 1996, 137: 85-89.
11. Sánchez-Criado J.E., Tébar M., Ruiz A., Padrón L. The steroid antagonist RU486 given at pro-oestrus induces hypersecretion of follicle-stimulating hormone from oestrus afternoon to early metoestrus in the rat. Eur. J. Endocrinol. 1997, 137: 281-286.
12. Tébar M., Ruiz A., Gaytán F., Sánchez-Criado J.E. Follicular and luteal progesterone play different roles synchronizing pituitary and ovarian events in the 4-day cyclic rat. Biol. Reprod. 1995, 53: 1183-1189.
13. Horwitz K. The molecular biology of RU486. Is there a role for antiprogestins in the treatment of breast cancer? Endocr. Rev. 1992, 13: 146-163.
14. Philibert D., Moguilewsky M., Mary I., Lecaque D., Tournemine C., Secchi J., Deraedt R. Pharmacological profile of RU486 in animals. In: Baulieu E.E., Segal S.J. (Eds.), The Antiprogestin Steroid RU486 and Human Fertility Control. Plenum Press, New York, 1985, p. 49.
15. Baulieu E.E. The antisteroid RU486. Its cellular and molecular mode of action. TEM 1991, 2: 233-239.
16. Waring D.W., Turgeon J.L. A pathway for luteinizing hormone releasing-hormone self potentiation: cross-talk with the progesterone receptor. Endocrinology 1992, 130: 3275-3282.
17. Turgeon J.L., Waring D.W. Activation of the progesterone receptor by the gonadotropin-releasing hormone self-priming signaling pathway. Mol. Endocrinol. 1994, 8: 860-869.
18. Brann D.W., Putnam C.D., Mahesh V.B. Validation of the mechanism proposed for the stimulatory and inhibitory effects of progesterone on gonadotropin secretion in the estrogen-primed rat: a possible role for adrenal steroids. Steroids 1991, 56: 103-111.
19. Brann D.W., Putnam C.D., Mahesh V.B. Corticosteroid regulation of gonadotropin and prolactin secretion in the rat. Endocrinology 1990, 126: 159-166.
20. Levine J.E. New concepts of the neuroendocrine regulation of gonadotropin surges in rats. Biol. Reprod. 1997, 56: 293-302.
21. Beck C.A., Zhang Y., Weigel N.L., Edwards D.P. Two types of antiprogestins have distinc effects on site-specific phosphorylation of human progesterone receptor. J. Biol. Chem. 1996, 271: 1209-1217.
22. Beck C.A., Estes P.A., Bona B.J., Muro-Cacho C.A., Nordeen S.K., Edwards D.P. The steroid antagonist RU486 exerts different effects on the glucocorticoid and progesterone receptors. Endocrinology 1993, 133: 728-740.
23. Mizutani T., Bhakta A., Kloosteroboer H.J., Moudgil V.K. Novel anti-progestins Org31806 and Org31710 interaction with mammalian progesterone receptor and DNA binding of anti-steroid receptor complexes. J. Steroid Biochem. Mol. Biol. 1992, 42: 695-704.
24. Greenwood F.C., Hunter W.M., Glover J.S. The preparation of 131-l-labeled human growth hormone of high specific radioactivity. Biochem. J. 1963, 89: 114-123.
25. Robertson D.M, Hayward S., Irby D., Jacobse J., Clarke L., McLachlan R.L., de Kretser D.M. Radioimmunoassay of rat serum inhibin: changes after PMSG stimulation and gonadectomy. Mol. Cell. Endocrinol. 1988, 58: 1-8.
26. Grootenhuis A.J., Steenbergen J., Timmerman M.A., Dorsman A.N., Schaaper W.M., Meloen R.H., de Jong F.H. Inhibin and activin-like activity in fluids from male and female gonads: different molecular weight form and bioactivity/immunoactivity ratios. J. Endocrinol. 1989, 122: 293-301.
27. McDonnell D.P. Unraveling the human progesterone receptor signal transduction pathway. Insights into antiprogestin action. TEM 1995, 6: 133-138.
28. Shaikh A.A., Shaikh S.A. Adrenal and ovarian steroid secretion in the rat estrous cycle temporally related to gonadotropins and steroid levels found in peripheral plasma. Endocrinology 1975, 96: 37-44.
29. Buckingham J.C., Döhler K.D., Wilson C.A. Activity of the pituitary-adrenocortical system and thyroid gland during the oestrous cycle of the rat. J. Endocrinol. 1978, 78: 359-366.
30. DePaolo L.V. Attenuation of preovulatory gonadotropin surges by epostane: a new inhibitor of 39-hydroxysteroid dehydrogenase. J. Endocrinol. 1988, 118: 59-68.
31. Mahesh V.B., Brann D.W. Interactions between ovarian and adrenal steroids in the regulation of gonadotropin secretion. J. Steroid Biochem. Mol. Biol. 1992, 41: 495-513.
32. Szabo M., Kilen S.M., Saberi S., Ringstrom S.J., Schwartz N.B. Antiprogestins suppress basal and activin-stimulated follicle-stimulating hormone secretion in an estrogen dependent manner. Endocrinology 1998, 139: 2223-2228.
33. Freeman M.E., Dupke K.C., Croteau C.M. Extintion of the estrogen-induced daily signal for LH release in the rat: a role for the proestrous surge of progesterone. Endocrinology 1976, 99: 223-229.
34. Lustig R.H., Pfaff D.W., Fishman J. Induction of LH hypersecretion in cyclic rats during the afternoon of oestrus by oestrogen in conjunction with progesterone antagonism or opioidergic blockade. J. Endocrinol. 1988, 117: 229-235.
35. Hasegawa Y., Miyamoto K., Igarashi M. Changes in serum concentrations of immunoreactive inhibin during the oestrous cycle of the rat. J. Endocrinol. 1989, 121: 91-100.
36. Tébar M., Ruiz A., Gonzalez D., Hernandez G., Alonso R., Sánchez-Criado J.E. Effect of RU486 on proestrous morning on LHRH, LH and 17β-estradiol secretion during the estrous cycle in the rat. J. Physiol. Biochem. 1998, 54: 91-98.
37. Sarkar D.K., Fink G. Effects of gonadal steroids on output of luteinizing hormone releasing factor into pituitary stalk blood in the female rat. J. Endocrinol. 1979, 80: 303-313.
38. McPherson J.C., Mahesh V.B. Dose related effects of a single injection of progesterone on gonadotropin secretion and pituitary sensitivity to LHRH in estrogen-primed castrate female rats. Biol. Reprod. 1979, 20: 763-772.
39. Power R.F., Mani S.K., Codina J., Conneely O.M., O'Malley B.W. Dopaminergic and ligand-independent activation of steroid hormone receptors. Science 1991, 254: 1636-1639.
40. Ignar-Trowbridge D.M., Teng C.T., Ross K.A., Parker M.G., Korach K.S., McLachlan J.A. Peptide growth factors elicit estrogen receptor-dependent transcriptional activation of an estrogen-responsive element. Mol. Endocrinol. 1993, 7: 992-998.
41. Katzenellenbogen B.S. Estrogen receptors: bioactivities and interactions with cell signalling pathways. Biol. Reprod. 1996, 54: 287-293.
42. Mani S.K, Allen J.M.C., Clark J.H., Blaustein J.D., O'Malley B.W. Convergent pathways for steroid hormone- and neurotransmitter-induced rat sexual behavior. Science 1994, 265: 1246-1249.
43. Ringstrom S.J., Szabo M., Kilen S.M., Saberi S., Knox K.L., Schwartz N.B. The antiprogestins RU486 and ZK98299 affect follicle stimulating hormone secretion differentially on estrus, but not on proestrus. Endocrinology 1997, 38: 2286-2290.