Alternative translation initiation codon for the human melanocortin MC3 receptor does not affect the ligand binding

European Journal of Pharmacology

Volumn 314, Issue 3, 1996, Pages 381-384

  Schiöth, Helgi B ^a   Muceniece, Ruta ^c   Wikberg, Jarl E S ^a,b   Szardenings, Michael ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b Wa Pharm   (Sweden)

^c NONE

Author keywords

Ligand binding; Melanocortin MC3 receptor; MSH (melanocyte stimulating hormone); Mutagenesis

Indexed keywords

HORMONE RECEPTOR; RECEPTOR PROTEIN; RECEPTOR SUBTYPE;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CELL STRAIN COS1; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; LIGAND BINDING; MOLECULAR CLONING; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; RNA TRANSLATION; TRANSLATION INITIATION;

BINDING, COMPETITIVE; CODON; GENOME, HUMAN; HUMANS; LOGISTIC MODELS; MELANOCYTE-STIMULATING HORMONES; MUTAGENESIS; PEPTIDE CHAIN INITIATION, TRANSLATIONAL; RECEPTORS, CORTICOTROPIN; RECEPTORS, MELANOCORTIN; SEQUENCE ANALYSIS; SEQUENCE ANALYSIS, DNA;

EID: 0343994310     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(96)00566-3     Document Type: Article

References (17)

1. Campbell, M.J., 1995, Lipofectin reagents prepared by a simple ethanol injection technique, BioTechniques 18, 1027.
2. Cavener, D.R. and S.C. Ray, 1991, Eurkaryotic start and stop translation sites, Nucleic Acids Res. 19, 3185.
3. Chhajlani, V. and J.E.S. Wikberg. 1992, Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA, FEBS Lett. 309, 417.
4. Chhajlani, V., R. Muceniece and J.E.S, Wikberg, 1993, Molecular cloning of a novel human melanocortin receptor, Biochem. Biophys. Res. Commun. 195, 866.
5. Chhajlani, V., X. Xu, J. Blauw and S. Sudarshi, 1996, Identification of ligand binding residues in extracellular loops of the melanocortin 1 receptor, Biochem. Biophys. Res. Commun. 219, 521.
6. Desarnaud, F., O. Labbé, D. Eggerickx, G. Vassart and M. Parmentier, 1994, Molecular cloning, functional expression and pharmacological characterization of a mouse melanocortin receptor gene, Biochem. J. 299, 367.
7. Eberle, A.N., 1988. The Melanotropins; Chemistry, Physiology and Mechanisms of Action (Karger, Basel, Switzerland) p. 252.
8. Fathi, Z., L.G. Iben and E.M. Parker, 1995, Cloning, expression, and tissue distribution of a fifth melanocortin receptor subtype, Neurochem Res. 20, 107.
9. Frändberg, P.A., R. Muceniece, P. Prusis, J.E.S. Wikberg and V. Chhajlani, 1994, Evidence for alternate points of attachment for α-MSH and its steroisomer NDP-MSH at the melanocortin 1 receptor, Biochem. Biophys. Res. Commun. 202, 1266.
10. Gantz, I., Y. Konda, T. Tashiro, Y. Shimoto, H. Miwa, G. Munzert, S.J. Watson, J. DelValle and T. Yamada, 1993a, Molecular cloning of a novel melanocortin receptor, J. Biol. Chem. 268, 8246.
11. Gantz, I., H. Miwa, Y. Konda, Y. Shimoto, T. Tashiro, S.J. Watson, J. DelValle and T. Yamada, 1993b, Molecular cloning, expression, and gene localization of a fourth melanocortin receptor, J. Biol. Chem. 268, 15174.
12. Kozak, M., 1984, Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs, Nucleic Acids Res. 12, 857.
13. Mountjoy, K.G., L.S. Robbins, M.T. Mortrud and R.D. Cone, 1992, The cloning of a family of genes that encode the melanocortin receptors, Science 257, 1248.
14. Prusis, P., P.A. Frändberg, R. Muceniece, I. Kalvinsh and J.E.S. Wikberg, 1995, A three dimentional model for the interaction of MSH with the melanocortin 1 receptor, Biochem. Biophys. Res. Commun. 210, 205.
15. Roselli-Rehfuss, L., K.G. Mountjoy, L.S. Robbins, M.T. Mortrud, M.J. Low, J.B. Tatro, M.L. Entwistle, R.B. Simerly and R.D. Cone, 1993, Identification of a receptor for γ melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system, Proc. Natl. Acad. Sci. USA 90, 8856.
16. Schiöth, H.B., R. Muceniece, J.E.S. Wikberg and V. Chhajlani, 1995, Characterisation of melanocortin receptor subtypes by radioligand binding analysis, Eur. J. Pharmacol. Mol. Pharmacol. Sect. 288, 311.
17. Siegrist W. and A.N. Eberle, 1995, Melanocortins and their implications in melanoma, Trends Endocrinol. Metab. 6, 115.