The effect of β-chloro D-alanine and L-cycloserine on the serine, phosphorus and palmitic acid uptake and metabolism of Tetrahymena lipids

Acta Biologica Hungarica

Volumn 50, Issue 4, 1999, Pages 363-373

  Kovacs P ^a  

^a SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

Author keywords

chloro D alanine; L cycloserine; Phospholip ids; Serine palmitoyltransferase; Tetrahymena

Indexed keywords

3 CHLOROALANINE; 3-CHLOROALANINE; ACYLTRANSFERASE; BETA ALANINE; CERAMIDE; CYCLOSERINE; DRUG DERIVATIVE; PALMITIC ACID; PHOSPHOLIPID; SERINE; SERINE PALMITOYLTRANSFERASE;

ANIMAL; ARTICLE; DRUG ANTAGONISM; METABOLISM; TETRAHYMENA PYRIFORMIS;

ACYLTRANSFERASES; ANIMALS; BETA-ALANINE; CERAMIDES; CYCLOSERINE; PALMITIC ACID; PHOSPHOLIPIDS; SERINE; SERINE C-PALMITOYLTRANSFERASE; TETRAHYMENA PYRIFORMIS;

ANIMALIA; TETRAHYMENA; TETRAHYMENA PYRIFORMIS;

EID: 0343920804     PISSN: 02365383     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Billah, M. M., Anthes, J. C. (1990) The regulation and cellular functions of phosphatidylcholine hydrolysis. Biochem. J. 269, 281-291.
2. Bligh, E. G., Dyer, W. J. (1959) A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37. 911-917.
3. Csaba, G., Nagy, S. U. (1976) Effect of vertebrate hormones on the cyclic AMP level in Tetrahymena. ActaBiol. Med. Germ. 35, 1399-1401.
4. Edwards, M. R., Knodler, L. A., Wilson, J. R., Schofield, P. J. (1993) The transport and metabolism of alanine by Giardia inteslinalis. Mol. Biochem. Parasitai. 61, 49-57.
5. Florin-Christensen, M., Florin-Christensen, J., Kaneshiro, E. S. (1995) Uptake and metabolism of L-serine by Pneumocystis carinii carinii. J. Eitk. Microbiol. 42, 669-675.
6. 1 and triacylglycerol lipase: two novel enzymes from Tetrahymena extracellular medium. Comp. Biochem. Physiol. 85B, 149-155.
7. Hegyesi, H., Csaba, G. (1994) A calcium-dependent protein kinase is present in Tetrahymena. Cell Biochem. Fund. 12, 221-226.
8. Kaneshiro, E. S., Merkel, S. J., Reuter, S. F. (1989) Uptake and utilization of small organic molecules by Paramecium letraurelia. Eur. J. Cell Biol. 49, 55-60.
9. Kaya, K., Ramesha, C. S., Thompson Jr., G. A. (1984) Temperature-induced changes in the hydroxy and non-hydroxy fatty acid-containing sphingolipids abundant in the surface membrane of Tetrahymenapyriformis NT-l .J. LipidRes. 25, 68-74.
10. Kolescnick, R., Golde, D. (1994) The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling. Cell 77, 325-328.
11. Kovâcs, P., Csaba, G. (1990) Involvement of the phosphoinositol (PI) system in the mechanism of hormonal imprinting. Biochem. Biophys. Res. Commun. 170, 119-126.
12. 2) and glycosyl-phosphatidylinositols (GPIs) of Tetrahymena pyriformis. Biosci. Rep. 14, 215-219.
13. Kovâcs, P., Csaba, G. (1995) Effect of 3-amino-1-propanol, indomethacin and 4-bromophenacyl bromide on the hormone binding of insulin pretreated Tetrahymena: influence of phospholipid metabolism disturbances on hormonal imprinting. Microbios 84, 255-261.
14. Kovâcs, P., Csaba, G. (1995) Effect of phorbol 12-myristate 13-acetate (PMA) on the phosphoinositol (PI) system in Tetrahymena. Study of the 32P incorporation and breakdown of phospholipids. Cell. Biochem. Fund. 13, 85-89.
15. Kovâcs, P., Csaba, G. (1996) Effects of local anaesthetics and phenothiazines on 32P-incorporation into the inositol phospholipids and glycosyl phosphatidylinositol of Tetrahymena pyriformis GL. Microbios 87. 149-159.
16. Kovâcs, P., Csaba, G. (1997) PLA2 activity in Tetrahymena pyriformis. Effects of inhibitors and stimulators. J. Lipid. Med. Cell Signal. 15, 233-247.
17. Kovâcs, P., Csaba, G. (1997) Indomethacin alters phospholipid and arachidonate metabolism in Tetrahymena pyriformis. Comp. Biochem. Physiol. 117C, 311-315.
18. Kovâcs, P., Csaba, G. (1998) Effect of ceramide-analogues on the actin cytoskeleton of Tetrahymena pyriformis GL. A confocal microscopic analysis. Acta Protozool. 37, 201-208.
19. Kovâcs, P., Csaba, G., Nagao, S., Nozawa, Y. (1989) The regulatory role of calmodulin-dependent guanylate cyclase in association with hormonal imprinting in Tetrahymena. Microbios 59, 123-128.
20. Kovâcs, P., Csaba, G., Nakashima, S., Nozawa, Y. (1997) Phospholipase D activity in the Tetrahymena pyriformis GL. Cell. Biochem. Fund. 15, 53-60.
21. Kovâcs, P., Hegyesi, H., Köhidai, L., Nemes, P., Csaba, G. (1999) Effect of C2 ceramide on the inositol phospholipid metabolism (uptake of 32P, 3H-serine and 3H-palmitic acid) and apoptosis-related morphological changes in Tetrahymena. Comp. Biochem. Physiol. 1220, 215-224.
22. Kovâcs, P., Köhidai, L., Csaba, G. (1998) Effects of tumor necrosis factor a (TNF a) on the phospholipid metabolism of Tetrahymena pyriformis. Cell. Biochem. Fund. 16, 87-97.
23. Köhidai, L., Bârsony, J., Roth, J., Marx, S. J. (1992) Rapid effect of insulin on cyclic GMP location in an intact protozoan. Experientia 48, 476-481.
24. Mallampalli, R. K., Mathur, S. N., Wamock, L. J., Salome, R. G., Hunninghake, G. W., Field, F. J. (1996) Betamethasone modulation of sphingomyelin hydrolysis up-regulates CTP : cholinephosphate cytidylyltransferase activity in adult rat lung. Biochem. J. 318, 333-341.
25. Medlock, K. A., Merrill, A. H. Jr. (1988) Inhibition of serine palmitoyltransferasc in vitro and long chain base biosynthesis in intact Chinese hamster ovary cells by beta-chloroalanine. Biochemistry 27, 7079-7084.
26. Merril, A. H. Jr., Wang, E., Mullins, R. E. (1988) Kinetics of long chain (sphingoid) base biosynthesis in intact LM cells: effects of varying the extracellular concentrations of serine and fatty acid precursors of this pathway. Biochemistry 27, 340-345.
27. Szablewsky, L., Andreasen, P. H., Tiedtke, A., Florin-Christensen, J., Florin-Christensen, M., Rasmussen, L. (1991) Tetrahymena thermophila: growth in synthetic nutrient medium in the presence and absence of glucose. J. Protozoa!. 38, 62-65.
28. Williams, R. D., Sgoutas, D. S., Zaatari, G. S., Santoianni, R. A. (1987) Inhibition of serine palmitoyltransferase activity in rabbit aorta by L-cycloserine. J. Lipid Res. 28, 1478-1481.