Prolonged cellular proliferation and pulmonary inflammation are produced in rats inhaling high concentrations of low-toxicity insoluble particulates: Comparisons with cytotoxic dusts

Inhalation Toxicology

Volumn 8, Issue SUPPL., 1996, Pages 155-167

  Warheit, D B ^a   Hansen, J F ^a   Yuen, I S ^a   Snajdr, S I ^a   Hartsky, M A ^a  

^a DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0343916028     PISSN: 08958378     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (11)

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2. Korkina, L. G., Durnev, A. D., Suslova, T. B., Cheremisina, Z. P., Daugel-Dauge, N. O., and Afansev, I. B. 1992. Oxygen radical-mediated mutagenic effect of asbestos on human lymphocytes: suppression by oxygen radical scavengers. Mutat. Res. 265:245-253.
3. 2) by inhalation for two years. Toxicol. Appl. Pharmacol. 79:179-192.
4. Morrow, P. E. 1988. Possible mechanisms to explain dust overloading of the lungs. Fundam. Appl. Toxicol. 10:369-384.
5. Morrow, P. E. 1992. Dust overloading of the lungs: Update and appraisal. Toxicol. Appl. Pharmacol. 113:1-12.
6. Oberdoerster, G., Ferin, J., and Morrow, P. E. 1992. Volumetric loading of alveolar macrophages (AM): A possible basis for diminished AM-mediated clearance. Exp. Lung Res. 18:87-104.
7. Warheit, D. B., Hill, L. H., and Brody, A. R. 1984a. Surface morphology and correlated phagocytic capacity of pulmonary macrophages lavaged from the lungs of rats. Exp. Lung Res. 6:71-82.
8. Warheit, D. B., Chang, L. Y., Hill, L. H., Hook, G. E. R., Crapo, J. D., and Brody, A. R. 1984b. Pulmonary macrophage accumulation and asbestos-induced lesions at sites of fiber deposition. Am. Rev. Respir. Dis. 129:301-310.
9. Warheit, D. B., Carakostas, M. C., Hartsky, M. A., and Hansen, J. F. 1991. Development of a short-term inhalation bioassay to assess pulmonary toxicity of inhaled particles: Comparisons of pulmonary responses to carbonyl iron and silica. Toxicol. Appl. Pharmacol. 107:350-368.
10. Warheit, D. B., Kellar, K. A., and Hartsky, M. A. 1992. Pulmonary cellular effects in rats following aerosol exposures to ultrafine Kevlar aramid fibrils: Evidence for biodegradability of inhaled fibrils. Toxicol. Appl. Pharmacol. 116:225-239.
11. Warheit, D. B., McHugh, T. A., and Hartsky, M. A. 1995. Differential pulmonary responses in rats inhaling crystalline, colloidal or amorphous silica dusts. Scant. J. Work Environ. Health 21(supppl. 2):19-21.