Apparent antinociceptive and anti-inflammatory effects of GYKI 52466

European Journal of Pharmacology

Volumn 336, Issue 2-3, 1997, Pages 143-154

  Székely, József I ^a   Kedves, Rita ^a   Máté, Ildikó ^a   Török, Katalin ^a   Tarnawa, István ^a  

^a Institute for Drug Research Budapest   (Hungary)

Author keywords

2,3 Benzodiazepine; Analgesia; Anti inflammatory drug; GYKI 52466; GYKI 53773; GYKI 53784

Indexed keywords

1 (4 AMINOPHENYL) 3,4 DIHYDRO 4 METHYL 3 METHYLCARBAMOYL 7,8 METHYLENEDIOXY 5H 2,3 BENZODIAZEPINE; 1 (4 AMINOPHENYL) 4 METHYL 7,8 METHYLENEDIOXY 5H 2,3 BENZODIAZEPINE; AMPA RECEPTOR ANTAGONIST; ANIRACETAM; BENZODIAZEPINE DERIVATIVE; DRUG METABOLITE; MORPHINE; NALOXONE; PARACETAMOL; TALAMPANEL; UNCLASSIFIED DRUG;

ANALGESIA; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ENANTIOMER; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION; SUBCUTANEOUS DRUG ADMINISTRATION;

ACETAMINOPHEN; ANALGESICS; ANIMALS; ANTI-ANXIETY AGENTS; ANTI-INFLAMMATORY AGENTS; ARTHRITIS, EXPERIMENTAL; BENZODIAZEPINES; BODY WEIGHT; EXCITATORY AMINO ACID ANTAGONISTS; FREUND'S ADJUVANT; HYPERALGESIA; INDOMETHACIN; MALE; MICE; MORPHINE; PAIN THRESHOLD; RATS; RATS, INBRED LEW; RATS, SPRAGUE-DAWLEY;

EID: 0343907708     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)01262-4     Document Type: Article

References (54)

1. Aanonsen L.M., Wilcox G.L. Nociceptive action of excitatory amino acids in the mouse: Effects of spinally administered opioids, phencyclidine and sigma agonists. J. Pharmacol. Exp. Ther. 243:1987;9-19.
2. Advokat C., Rutherford D. Selective antinociceptive effect of excitatory amino acid antagonists in intact and acute spinal rats. Pharmacol. Biochem. Behav. 51:1995;855-860.
3. Advokat C., Prejean J., Bertman L. Intrathecal coadministration of morphine and excitatory amino acid agonists produce differential effects on the tail-flick of intact and spinal rats. Brain Res. 641:1994;135-140.
4. Bolton, S., 1990. Linear regression and correlation. In: Bolton, S. (Ed.), Pharmaceutical Statistics. Dekker, New York, pp. 210-234.
5. Budai D., Larson A.A. GYKI 52466 inhibits AMPA/kainate and peripheral mechanical sensory activity. NeuroReport. 5:1994;881-884.
6. Chapman A.G., Al-Zubaidy Z., Meldrum B.S. Aniracetam reverses the anticonvulsant action of NBQX and GYKI 52466 in DBA/2 mice. Eur. J. Pharmacol. 231:1993;301-303.
7. Cumberbatch M.J., Chizh B.A., Headley P.M. AMPA receptors have an equal role in spinal nociceptive and non-nociceptive transmission. Neuroreport. 5:1994;877-880.
8. D'Amour F.E., Smith D.L. A method for determining loss of pain sensation. J. Pharmacol. Exp. Ther. 72:1941;74-79.
9. Danysz W., Parsons C.G., Bresink I., Quack G. Glutamate in CNS disorders. Drug News Perspect. 8:1995;261-277.
10. Davar G., Hama A., Deykin A., Vos B., Maciewicz R. MK-801 blocks the development of thermal hyperalgesia in a rat model of experimental painful neuropathy. Brain Res. 553:1991;327-330.
11. Davies S.N., Lodge D. Evidence for involvement of N-methylaspartate receptors in 'wind-up' of class 2 neurones in the dorsal horn of the rat. Brain Res. 424:1987;402-406.
12. De Sarro G., Chimirri A., De Sarro A., Gitto R., Grasso S., Giusti P., Chapman A.G. GYKI 52466 and related 2,3-benzodiazepines as anticonvulsant agents in DBA/2 mice. Eur. J. Pharmacol. 294:1995;411-422.
13. Dickenson A.H., Sullivan A.F. Differential effects of excitatory amino acid antagonists on dorsal horn nociceptive neurons in the rat. Brain Res. 506:1990;31-39.
14. Donevan S.D., Rogawski M.A. GYKI 52466, a 2,3-benzodiazepine, is a highly selective, noncompetitive antagonist of AMPA/kainate receptor responses. Neuron. 10:1993;51-59.
15. Donevan S.D., Yamaguchi S.-I., Rogawski M.A. Non-N-methyl-D-aspartate receptor antagonism by 3-N-substituted 2,3-benzodiazepines: Relationship to anticonvulsant activity. J. Pharmacol. Exp. Ther. 271:1994;25-29.
16. Dray A., Urban L. New pharmacological strategies for pain relief. Ann. Rev. Pharmacol. 36:1996;253-280.
17. Dray A., Urban L., Dickenson A. Pharmacology of chronic pain. Trends Pharm. Sci. 15:1994;190-197.
18. Dubner R., Ruda M.A. Activity-dependent neuronal plasticity following tissue injury and inflammation. Trends Neurosci. 15:1992;96-103.
19. Eddy N.B., Fuhrmeister-Touchberry C., Lieberman J.E. Synthetic analgesics. I. Methadone isomers and derivatives. J. Pharmacol. Exp. Ther. 98:1950;121-137.
20. Eisenberg E., LaCross S., Strassman A.M. The effects of clinically tested NMDA receptor antagonist memantine on carrageenin-induced thermal hyperalgesia in rats. Eur. J. Pharmacol. 255:1994;123-129.
21. Farkas S., Ono H. Participation of NMDA and non-NMDA excitatory amino acid receptors in the mediation of spinal reflex potentials in rats: An in vivo study. Br. J. Pharmacol. 114:1995;1193-1205.
22. Farkas, S., Tarnawa, I., Berzsenyi, P., Pátfalusi, M., Andrási, F., Ono, H., 1992. The role of non-N-methyl-D-aspartic acid exciatory amino acid receptors in mediation of spinal reflexes. In: Takai, K. (Ed.), Frontiers and New Horizons in Amino Acid Research. Elsevier, Amsterdam, pp. 471-475.
23. Ferreira S.H., Lorenzetti B.B. Glutamate spinal retrograde sensitization of primary sensory neurons associated with nociception. Neuropharmacology. 33:1994;1479-1485.
24. Fundytus M.E., Coderre T.J. Effect of activity at metabotropic, as well as ionotropic (NMDA) glutamate receptors on morphine dependence. Br. J. Pharmacol. 113:1994;1215-1220.
25. Haley J.E., Sullivan A.F., Dickenson A.H. Evidence for spinal N-methyl-D-aspartate receptor involvement in prolonged chemical nociception in the rat. Brain Res. 518:1990;218-226.
26. Harris J.A., Corsi M., Quartaroli M., Arban R., Bentivoglio M. Upregulation of spinal glutamate receptors in chronic pain. Neuroscience. 74:1996;7-12.
27. Hendershot L.C., Forsaith J. Antagonism of the frequency of phenylquinone-induced writhing in the mouse by weak analgesics and nonanalgesics. J. Pharmacol. Exp. Ther. 125:1959;237-240.
28. Horváth E.J., Hudák J., Palkovits M., Lenkei Z., Fekete M.I.K., Arányi P. A novel specific binding site for homophtalazines in the rat brain. Eur. J. Pharmacol. 236:1993;151-153.
29. Hunter J.C., Singh L. Role of excitatory acid receptors in the mediation of the nociceptive response to formalin in the rat. Neurosci. Lett. 174:1994;217-221.
30. Hylden J.L.K., Nahin R.L., Traub R.J., Dubner R. Expansion of the receptive fields of spinal lamina I projection neurons in rats with unilateral adjuvant-induced inflammation: The contribution of dorsal horn mechanisms. Pain. 37:1989;229-243.
31. Jackson D.L., Graff C.B., Richardson J.D., Hargreaves K.M. Glutamate participates in the peripheral modulation of thermal hyperalgesia in rats. Eur. J. Pharmacol. 284:1995;321-325.
32. Kallman, M.J., Tizzaro, J.P., Modin, D.L., Griffey, K., Helton, D.R., 1995. Behavioral characterization of a noncompetitive AMPA antagonist LY-300164. XXV Ann. Meeting Soc. Neurosci. San Diego, California, November 11-16, Abstr., p. 34.
33. Litchfield J.T. Jr., Wilcoxon F. A simplified method of evaluating dose-effect experiments. J. Pharmacol. Exp. Ther. 96:1949;99-113.
34. Malmberg A.B., Yaksh T.N. Hyperalgesia mediated by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibition. Science. 257:1995;1276-1279.
35. Mao J., Price D.D., Hayes R.L., Lu J., Mayer D.J. Differential roles of N-methyl-D-aspartic acid and non-N-methyl-D-aspartic acid receptor activation in induction and maintenance of thermal hyperalgesia in rats with painful peripheral mononeuropathy. Brain Res. 598:1992;271-278.
36. Näsström J., Karlsson U., Post C. Antinociceptive actions of different classes of excitatory amino acid receptor antagonists in mice. Eur. J. Pharmacol. 212:1992;21-29.
37. Newbould B.B. Chemotherapy of arthritis induced in rats by mycobacterial adjuvant. Br. J. Pharmacol. 21:1963;127-136.
38. Palmer A.J., Lodge D. Cyclothiazide reverses the AMPA receptor antagonism of the benzodiazepine, GYKI 53655. Eur. J. Pharmacol. 244:1993;193-194.
39. Randall L.O., Selitto J.J. A method for measurement of analgesic activity on inflamed tissue. Arch. Int. Pharmacodyn. 111:1957;409-419.
40. Ren K., Hylden J.L.K., Williams G.M., Ruda M.A., Dubner R. The effects of non-competitive NMDA receptor antagonist, MK-801, on behavioral hyperalgesia and dorsal horn neuronal activity in rats with unilateral inflammation. Pain. 50:1992;331-344.
41. Schouenborg J., Sjölund B.H. First-order nociceptive synapses in rat dorsal horn are blocked by amino acid antagonists. Brain Res. 379:1986;394-398.
42. Sluka K.A., Westlund K.N. Centrally administered non-NMDA receptor antagonists block peripheral knee joint inflammation. Pain. 55:1993;217-225.
43. Sluka K.A., Willis W.D., Westlund K.N. Joint inflammation and hyperalgesia are reduced by spinal bicuculline. NeuroReport. 5:1993;109-112.
44. Smith E., Meldrum B.S. Receptor site specificity for the acute effects of β-N-methylamino-alanine in mice. Eur. J. Pharmacol. 187:1990;131-134.
45. Song X.-J., Zhao Z.-Q. Differential effects NMDA and non-NMDA receptor antagonists on spinal cutaneous versus muscular nociception in the cat. NeuroReport. 4:1993;17-20.
46. Stein C., Millan M.J., Yassouridis A., Herz A. Antinociceptive effects of μ- and κ-agonists in inflammation are enhanced by a peripheral opioid-specific mechanism. Eur. J. Pharmacol. 155:1988;255-264.
47. Székely, J.I., Máté, I., Török, K., Berzsenyi, P., Andrási, F., Tarnawa, I., 1995. Apparent antinociceptive and antiphlogistic effects of GYKI 52466, a 2,3-benzodiazepine, in some animal models. XXVI Int. Narcotics Res. Conf. Fife, Scotland, July 9-13, Abstr., p. 65.
48. Székely, J.I., Kedves, R., Török, K., Tarnawa, I., 1996. Further data on the apparent antinociceptive and antiphlogistic effects of 2,3-benzodiazepines. XXVII Int. Narcotics Res. Conf. Long Beach, California, July 21-26, Abstr., p. 96.
49. Tarnawa I., Farkas S., Berzsenyi P., Pataki Á., Andrási F. Electrophysiological studies with a 2,3-benzodiazepine muscle relaxant: GYKI 52466. Eur. J. Pharmacol. 167:1989;193-199.
50. Tarnawa I., Berzsenyi P., Andrási F., Botka P., Hámori T., Ling I., Kôrösi J. Structure-activity relationships of 2,3-benzodiazepine compounds with glutamate antagonistic action. Bioorg. Med. Chem. Lett. 3:1993;99-104.
51. Urban L., Thompson S.W.N., Dray A. Modulation of spinal excitability: Cooperation between neurokinin and excitatory acid neurotransmitters. Trends Neurosci. 17:1994;432-438.
52. Witkin L.B., Heubner C.F., Gáldi F., O'Keefe E., Spitaletta P., Plummer A.J. Pharmacology of 2-amino-indane hydrochloride (SU-8629): A potent nonnarcotic analgesic. J. Pharmacol. Exp. Ther. 133:1961;400-408.
53. Woolf C.J., Thompson S.W.N. The induction and maintenance of central sensitization is dependent on N-methyl-D-aspartic acid receptor activation: Implications for the treatment of post-injury pain hypersensitivity states. Pain. 44:1991;293-299.
54. Xu X.J., Hao J.X., Seiger A., Wiesenfeld-Halin Z. Systemic excitatory acid receptor antagonists of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor and of N-methyl-D-aspartate (NMDA) receptor relieve mechanical hypersensitivity after transient spinal cord ischemia in rats. J. Pharmacol. Exp. Ther. 267:1993;140-144.