Stimulatory effects of ginsenosides on bovine brain glutamate decarboxylase

Journal of Biochemistry and Molecular Biology

Volumn 31, Issue 3, 1998, Pages 233-239

  Choi, Soo Young ^a   Bahn, Jae Hoon ^a   Jeon, Seong Gyu ^a   Chung, Young Mee ^a   Hong, Joung Woo ^a   Ahn, Jee Yin ^a   Lee, Eunjoo Hwang ^a   Cho, Sung Woo ^b   Park, Jinkyu ^c   Baek, Nam In ^d  

^a Hallym University   (South Korea)

^b University of Ulsan College of Medicine   (South Korea)

^c Korea Ginseng Corporation   (South Korea)

^d Kyung Hee University   (South Korea)

Author keywords

Activation; Brain; GABA shunt; Ginsenosides; Glutamate decarboxylase

Indexed keywords

EID: 0343859968     PISSN: 12258687     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Bradford, M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein using the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
2. Chang, W. A. and Kim, C. J. (1974) Influence of panax ginseng upon gastric ulceration produced by Restraint. J. Cath. Med. Coll. 27, 249-255.
3. Cho, S. W., Song, M. S., Kim, G. Y, Kang, W. D., Choi, E. Y., and Choi, S. Y. (1993) Kinetics and mechanism of an NADPH-dependent succinic semialdehyde reductase from bovine brain. Eur. J. Biochem. 211, 757-762.
4. Choi, S. Y., Han, K., Jang, S. H., Song, M. S., Kim, Y. K., Choe, J. H., and Cho, S. W. (1994a) Interaction of phospholipid with brain glutamate decarboxylase. Kor. Biochem. J. 27, 249-253.
5. Choi, S. Y., Kim, I., Jang, S. H., Lee, S. J., Song, M. S., Lee, Y. S., and Cho, S. W. (1993) Purification and properties of GABA transaminase from bovine brain. Mol. Cells 3, 397-401.
6. Choi, S. Y., Lee, B. R., Jang, S. H., Song, M. S., Wee, S., Choi, E. Y., Lee, K. S., and Lee, H. B. (1994b) Reaction of phospholipid with brain glutamate decarboxylase. Exp. Neurobiol. 3, 39-45.
7. Davis, B. J. (1964) Disc gel electrophoresis II. Method and application to human serum proteins. Ann. N.Y. Acad. Sci. 121, 404-427.
8. De Biase, D., Barra, D., Bossa, F., Pucci, P., and John, R. H. (1991) Chemistry of the inactivation of 4-aminobutyrate aminotransferase by the antiepileptic drug vigabatrin. J. Biol. Chem. 266, 20056-20061.
9. Fletcher, A. and Fowler, L. J. (1980) 4-aminobutyric acid metabolism in rat brain following chronic oral administration of ethanolamine-O-sulfate. Biochem. Pharmacol. 29, 1451-1454.
10. Kim, H., Chen, X., and Gillis, N. (1992) Ginsenosides protect pulmonary vascular endothelium against free radical-induced injury. Biochem. Biophys. Res. Commun. 189, 670-676.
11. Kim, J. W., Kim, J. W., Lee, H. B., and Joo, C. N. (1985) Biochemical studies on ginseng saponin(XXV): Ginseng saponin-protein interaction. Kor. Biochem. J. 18, 453-458.
12. Lee, B. R., Hong, J. W., Yoo, B. K., Lee, S. J., Cho, S. W., and Choi, S. Y. (1995a) Bovine brain succinic semialdehyde dehydrogenase: Purification, kinetics and reactivity of lysyl residues connected with catalytic activity. Mol. Cells 5, 611-617.
13. Lee, S. C., Lee, S. J., Chung, K. S., You, K. H., and Kim, H. S. (1995b) The central effects of red ginseng total saponin component. Korean J. Ginseng Sci. 19, 22-26.
14. Lee, S. C., Yoo, K. H., and Yamamoto, T. (1995c) Behavioral pharmacological studies of nootropic candidates on the central dopaminergic activity in rats. Korean J. Ginseng Sci. 19, 197-201.
15. Lim, S. Y. and Kim, C. C. (1982) Influence upon male rats' sexual behavior of ginseng administered before and after mature state. J. Cath. Med. Coll. 35, 9-14.
16. Lippert, B., Metcalf, B. Y., Jung, M. J., and Casara, P. (1977) 4-Aminohex-5-enoic acids: a selective catalytic inhibitor of 4-aminobutyrate aminotransferase in mammalian brain. Eur. J. Biochem. 74, 441-445.
17. 3H]-γ-aminobutyrate binding in the human brain. Alteration in Parkinson's disease. Brain, Res. 127, 269-275.
18. Nabata, H., Saito, H., and Takagi, K. (1973) Pharmacological studies of neutral saponins (GNS) of panax ginseng root. Jpn. J. Pharmacol. 23, 29-41.
19. Park, J. K., Chepurnov, S. A., Chepurnova, N. E., and Nam, K. Y (1995) Effects of Korean red ginseng on memory deficit and seizure susceptibility following hyperthermia induced in the rat pups, in Proceedings of '95 Korea-Japan Ginseng Symposium, pp. 89-102.
20. Perry, T. L., Hansen, S., and Kloster, M. (1973) Huntington's chorea: Deficiency of 4-aminobutyric acid in brain. New. Engl. J. Med. 288, 337-342.
21. Petkov, V. D. (1978) Effects of ginseng on the brain biogenic monoamines and 3′,5′-AMP system: Experiments on rat. Arzeim. Forsch. 28, 388-393.
22. Takagi, K., Saito, H., and Nabata, H. (1972) Pharmacological studies of panax ginseng root: Estimation of pharmacological action of panax ginseng root. Jpn. J. Pharmacol. 22, 245-259.
23. Wada, H. and Snell, E. E. (1961) The enzymatic oxidation of pyridoxine and pyridoxamine phosphates. J. Biol. Chem. 236, 2089-2095.
24. Wu, J. Y. (1983) Purification, characterization and kinetic studies of GAD and GABA-T from mouse brain; in Glutamine Glutamate and GABA in the Central Nervous System, Hertz, L., Kvamme, E., McGeer, E.G., and Schousboe, A. (eds.), pp. 161-176, Alan Liss, New York.