Cyclic GMP attenuates cyclic AMP-stimulated inotropy and oxygen consumption in control and hypertrophic hearts

Basic Research in Cardiology

Volumn 95, Issue 1, 2000, Pages 28-38

  Leone Jr , Richard J ^a   Straznicka, Michaela ^a   Scholz, Peter M ^a   Weiss, Harvey R ^a  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

3 Morpholinosyndnonimine; Cyclic AMP; Cyclic GMP; Isoproterenol; Rabbit

Indexed keywords

CYCLIC AMP; CYCLIC GMP; ISOPRENALINE; MORPHOLINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL GAS; ARTICLE; ATTENUATION; BLOOD GAS; CONTROLLED STUDY; DRUG INHIBITION; HEART HYPERTROPHY; INOTROPISM; NONHUMAN; OXYGEN CONSUMPTION; RABBIT; RENOVASCULAR HYPERTENSION;

ANIMALS; CARDIOMEGALY; CARDIOTONIC AGENTS; CYCLIC AMP; CYCLIC GMP; ISOPROTERENOL; MOLSIDOMINE; MYOCARDIAL CONTRACTION; OXYGEN CONSUMPTION; RABBITS; VASODILATOR AGENTS;

EID: 0343851721     PISSN: 03008428     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003950050005     Document Type: Article

References (32)

1. Bolli R, Hartley CJ, Chelly JE, Patel BS, Rabinovitz RS, Jeroudino, Roberts R, Noon G (1990) An accurate, nontraumatic ultrasonic method to monitor myocardial wall thickening in patients undergoing cardiac surgery. J Am Coll Cardiol 15: 1055-1065
2. Borutaite V, Brown GC (1996) Rapid reduction of nitric oxide by mitochondria, and reversible inhibition of mitochondrial respiration by nitric oxide. Biochem J 315: 295-299
3. Brown GC (1995) Nitric oxide regulates mitochondrial respiration and cell functions by inhibiting cytochrome oxidase. FEBS Lett 369: 136-139
4. 2 supply/consumption in hypertension-induced myocardial hypertrophy. Am J Physiol 259: H346-H351
5. Guo X, Kedem J, Weiss HR, Tse J, Roitstein A, Scholz PM (1996) Effect of cyclic GMP reduction on regional myocardial mechanics and metabolism in experimental left ventricular hypertrophy. J Cardiovasc Pharmacol 27: 392-400
6. Hove-Madsen L, Mery PF, Jurevicius J, Skeberdis AV, Fischmeister R (1996) Regulation of myocardial calcium channels by cyclic AMP metabolism. Basic Res Cardiol 91 (Suppl 2): 1-8
7. Hyman AL, Kadowitz PJ, Lippton HL (1989) Methylene blue selectively inhibits pulmonary vasodilator responses in cats. J Appl Physiol 66: 1513-1517
8. Joe EK, Schussheim AE, Longrois D, Maki T, Kelly RA, Smith TW, Balligand JL (1998) Regulation of cardiac myocyte contractile function by inducible nitric oxide synthase (iNOS): mechanisms of contractile depression by nitric oxide. J Molec Cell Cardiol 30: 303-315
9. Kelm M, Schrader J (1990) Control of coronary vascular tone by nitric oxide. Circ Res 66: 2562-2575
10. Laragh JH (1986) Renovascular hypertension: a paradigm for all hypertension. J Hyperten 4 (Suppl 4): S79-S88
11. Leone RJ Jr, Weiss HR, Scholz PM (1998) Positive functional effects of milrinone and methylene blue are not additive in control and hypertrophic canine hearts. J Surg Res 77: 23-28
12. Lohmann SM, Fischmeister R, Walter U (1991) Signal transduction by cGMP in heart. Basic Res Cardiol 86: 503-514
13. Mohan P, Sys SU, Brutsaert DL (1995) Positive inotropic effect of nitric oxide in myocardium. Intern J Cardiol 50: 233-237
14. Naim KL, Rabindranauth P, Weiss HR, Tse J, Leone RJ Jr, Scholz PM (1998) Positive inotropy due to lowering cyclic GMP is also mediated by increases in cyclic AMP in control and hypertrophic hearts. Canad J Physiol Pharmacol 76: 605-612
15. Nichols JR, Gonzalez NC (1982) Increase in myocardial cell cGMP concentration in pressure-induced myocardial hypertrophy. J Molec Cell Cardiol 14: 181-183
16. Paulus WJ, Vantrimpont PJ, Shah AM (1994) Acute effects of nitric oxide on left ventricular relaxation and diastolic distensibility in humans: Assessment of bicoronary sodium nitroprusside infusion. Circulation 89: 2070-2078
17. Penny DJ, Chen H, Smolich JJ (1998) Increased aortic blood pressure contributes to potentiated dobutamine inotropic responses after systemic NO synthase inhibition in sheep. Cardiovasc Res 40: 282-289
18. Rabindranauth P, Naim KL, Scholz PM, Tse J, Sadoff JD, Weiss HR (1997) Negative metabolic effects of cyclic GMP are altered in renal hypertension induced cardiac hypertrophy. Basic Res Cardiol 92: 8-16
19. Roitstein A, Kedem J, Cheinberg B, Weiss HR, Tse J, Scholz PM (1994) The effect of intracoronary nitroprusside on cyclic GMP and regional mechanics is altered in a canine model of left ventricular hypertrophy. J Surg Res 57: 584-590
20. Sadoff JD, Scholz PM, Weiss HR (1996) Endogenous basal nitric oxide production does not control myocardial oxygen consumption or function. Proc Soc Exp Biol Med 211: 332-338
21. 2 consumption in control but not renal-hypertension-induced cardiac hypertrophy. Cardiovasc Res 36: 453-459
22. Scholz PM, Upsher ME, Eliades D, Kedem J, Weiss HR (1990) Alterations in the regional β-adrenergic system in experimental left ventricular hypertrophy. Cardiovasc Res 24: 65-71
23. Sharma RK (1995) Signal transduction: regulation of cAMP concentration in cardiac muscle by calmodulin-dependent cyclic nucleotide phosphodiesterase. Molec Cell Biochem 149: 241-247
24. Sperelakis N, Tohse N, Ohya Y, Masuda H (1994) Cyclic GMP regulation of calcium slow channels in cardiac muscle and vascular smooth muscle cells. Adv Pharmacol 26: 217-252
25. Trautwein W, Trube G (1976) Negative inotropic effects of cyclic GMP in cardiac fiber fragments. Pflügers Arch 366: 293-295
26. Trautwein W, Taniguchi J, Noma A (1982) The effect of intracellular cyclic nucleotides and calcium on the action potential and acetylcholine response of isolated cardiac cells. Pflügers Arch 392: 307-314
27. Ungureanu-Longrois D, Bezie Y, Perret C, Laurent S (1997) Effects of exogenous and endogenous nitric oxide on the contractile function of cultured chick embryo ventricular myocytes. J Molec Cell Cardiol 29: 677-687
28. Wahler GM, Dollinger SJ (1995) Nitric oxide donor SIN-1 inhibits mammalian cardiac calcium current through cGMP-dependent protein kinase. Am J Physiol 268: C45-C54
29. Weiss HR, Sinha AK (1978) Regional oxygen saturation of small arteries and veins in the canine myocardium. Circ Res 42: 119-126
30. Weiss HR, Rodriguez E, Tse J, Scholz PM (1994) Effect of increased myocardial cyclic GMP induced by cyclic GMP-phosphodiesterase inhibition on oxygen consumption and supply of rabbit hearts. Clin Exp Pharmacol Physiol 21: 607-614
31. Wright CC, Kedem J, Weiss HR, Rodriguez E, Wong E, Mackenzie JW, Scholz PM (1991) Relationship between adenylate cyclase activity and regional myocardial energetics in experimental left ventricular hypertrophy. J Surg Res 50: 537-544
32. Zhu NH, Weiss HR (1991) Oxy- and carboxyhemoglobin saturation determination in frozen small vessels. Am J Physiol 260: H626-H631