Novenamines as inhibitors of two independent enzymes during DNA replication in a toluenized Escherichia coli cell system

Biochemical Pharmacology

Volumn 51, Issue 10, 1996, Pages 1373-1378

  Althaus, Irene W ^a   Kézdy, Ferenc J ^a   Peterson, Tillie ^a   Spilman, Charles H ^a   Reusser, Fritz ^a  

^a PFIZER INC   (United States)

Author keywords

amphiphilic inhibitors; bacterial DNA replication; gyrase; novenamines; topoisomerases

Indexed keywords

AMPHOPHILE; GYRASE INHIBITOR; MONOMER; NOVENAMINE; NOVOBIOCIN; TOLUENE; U 34445; U 35122; U 35401; U 6391; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA REPLICATION; DNA SYNTHESIS INHIBITION; ESCHERICHIA COLI; KINETICS; MICELLE; NONHUMAN; PRIORITY JOURNAL;

EID: 0343807216     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(96)00061-5     Document Type: Article

References (8)

1. Althaus IW, Franks KM, Langley KB, Kézdy FJ, Peterson T, Buxser SE, Dolak LA, Ulrich RG and Reusser F, The amphiphilic properties of novenamines determine their activity as inhibitors of HIV-1 RNase H. Experientia, in press.
2. Gellert M, O'Dea MH, Itoh T and Tomizawa J, Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase. Proc Natl Acad Sci USA 73: 4474-4478, 1976.
3. Reusser F and Dolak L, Novenamine is the active moiety in novobiocin. J Antibiot (Tokyo) 39: 272-274, 1986.
4. Althaus IW, Dolak L and Reusser F, Coumarins as inhibitors of bacterial DNA gyrase. J Antibiot (Tokyo) 41: 373-376, 1988.
5. Gellert M, DNA topoisomerases. Annu Rev Biochem 50: 879-910, 1981.
6. Moses RE and Richardson CC, Replication and repair of DNA in cells of Escherichia coli treated with toluene. Proc Natl Acad Sci USA 67: 674-681, 1970.
7. Moses RE, Replicative deoxyribonucleic acid synthesis in a system diffusible for macromolecules. J Biol Chem 247: 6031-6038, 1972.
8. Kornberg A, DNA replication. J Biol Chem 263: 1-4, 1988.