Effect of acetyl-L-carnitine on ethanol consumption and alcohol abstinence syndrome in rats

Drugs under Experimental and Clinical Research

Volumn 26, Issue 1, 2000, Pages 7-12

  Mangano, N G ^b   Clementi, G ^c   Costantino, G ^c   Calvani, M ^a   Matera, M ^c  

^a Sigma Tau SpA   (Italy)

^b UNIVERSITY OF CATANIA   (Italy)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCARNITINE; ALCOHOL;

ALCOHOL ABSTINENCE; ALCOHOL CONSUMPTION; ALCOHOLISM; ANIMAL EXPERIMENT; ARTICLE; HYPERACTIVITY; MALE; MUSCLE RIGIDITY; NONHUMAN; RAT; SEIZURE; SPASTICITY; TREMOR; WITHDRAWAL SYNDROME;

ACETYLCARNITINE; ALCOHOL DRINKING; ANIMALS; DOPAMINE; MALE; RATS; RATS, WISTAR; SUBSTANCE WITHDRAWAL SYNDROME;

EID: 0343729525     PISSN: 03786501     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Mirovsky Y., Wagner G.C., Sekowski A., Goldberg M., Fisher H. Simultaneous changes in striated dopamine, serotonin, and metabolites after withdrawal seizures in rats from dependence on alcohol. Alcohol, 12(3), 251, 1995.
2. Hosein E.A., Koh T.Y. Acetylcholine-like activity of acetyl-L-carnityl coA in subcellular particles of narcotized brain homogenates. Arch. Biochem. Biophys. 114(1), 94, 1966.
3. Friedman S. Reversible enzymatic acetylation of carnitine. Arch. Biochem. Biophys., 59, 491, 1985.
4. Falchetto S., Kato G., Provini L. The action of carnitines on cortical neurons. Can. J. Pnysiol. Pharmacol., 49, 1, 1971.
5. Nevo I., Hamon M. Neurotransmitter and neuromodulatory mechanisms involved in alcohol abuse and alcoholism. Nourochem. Int., 26(4), 305, 1995.
6. Diana M., Rossetti Z.L., Gessa G. Rewarding and aversive effects of ethanol: Interplay of GABA, glutamate and dopamine. Alcohol Suppl., 2, 315, 1995.
7. Propping P. Genetic control of ethanol action on the central nervous system. Hum. Genet., 35, 309, 1977.
8. Bohman M. Some genetic aspects of alcoholism and criminality. A population of adoptees. Arch. Gen. Psychiatry, 35, 269, 1978.
9. Blanchard B.A., Glick S.D. Sex differences in mesolimbic dopamine responses to ethanol and relationship to ethanol intake in rats. Recent Dev. Alcohol, 12, 321, 1995.
10. Liljequist S., Karcz-Kubicha M. Genetic aspects of the effects of ethanol and central stimulants on locomotor activity and brain dopamine metabolism in mice. Alcohol Suppl., 2, 457, 1995.
11. Phillips T.J., Crabbe J.C., Metten P., Belknap J.K. Localization of genes affecting alcohol drinking in mice. Alcohol Clin. Exp. Res., 18(4), 931, 1995.
12. McSwigan J.D., Crabbe J.C., Young E.R. Specific ethanol withdrawal seizures in genetically selected mice. Life Sci., 35, 2119, 1984.
13. Majchrowicz E., Hunt W. Temporal relationship of the induction of tolerance and physical dependence after continous intoxication with maximum tolerable doses of ethanol in rats. Psychopharmacology, 50, 107, 1976.
14. Burdick J.A., Johnson L.C., Smith J.W. Measurements of change during alcohol withdrawal in chronic alcoholics. Br. J. Addict. Alcohol Other Drugs. 65(4), 273, 1970.
15. Fadda F., Colombo G., Mosca E., Gessa G.L. Suppression by gamma-hydroxybutyric acid of ethanol withdrawal syndrome in rats. Alcohol Alcoholism, 24, 447, 1989.
16. Goldstein D.B., Pal N. Alcohol dependence produced in mice by inhalation of ethanol: Grading the withdrawal reaction. Science, 172, 288, 1971.
17. Hunt W.A., Majchrowicz E. Suppression of the ethanol withdrawal syndrome by aliphatic diols. J. Pharmacol. Exp. Ther., 213, 9, 1980.
18. Sachan D.S. Carnitine-mediated attenuation of ethanol etabolism. In: Carter A.L. (Ed.). "Current Concepts in Carnitine Research". CRC Press, Florida, 1992, pp. 79-91.
19. Sachan D.S., Cha Y.S. Acetylcarnitine inhibits alcohol dehydrogenase. Biochem. et Biophys. Res. Commun., 203(3), 1496, 1994.
20. Sershen H., Harsing L.G. Jr., Banay-Schwartz M., Hashim A., Ramacci M.T., Lajtha A. Effect of acetyl-L-carnitine on the dopaminergic system in aging brain. J. Neurosci. Res., 30(3), 555, 1991.
21. Harsin L.G., Sershen H., Toth E., Hashim A., Ramacci M.T., Lajtha A. Acetyi-L-carnitine releases dopamine in rat corpus striatum: An in vivo microdialysis study. Eur. J. Pharm., 218(1), 117, 1992.
22. Mereu G., Gessa G.L. Low doses of ethanol inhibit the firing of neurons in the substantia nigra, pars reticulata: A GABAergic effect? Brain Res., 360, 325, 1985.
23. Imperato A., Di Chiara G. Preferential stimulation of dopamine release in the nucleus accumbens of freely moving rats by ethanol. J. Pharmacol. Exp. Ther., 239, 219, 1986.
24. Darden G.H., Hunt W.A. Reduction of striatal dopamine release during an ethanol withdrawal syndrome. J. Neurochem., 31, 1223, 1977.