Aging impairs heart rate reflexes earlier in female than in male Sprague-Dawley rats

Neurobiology of Aging

Volumn 17, Issue 1, 1996, Pages 87-93

  Buñag, Ruben D ^a   Davidow, Lawrence W ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

Aging; Baroreflexes heart rate; Blood pressure; Gender differences; Phenylephrine; Sodium nitroprusside

Indexed keywords

NITROPRUSSIDE SODIUM; PHENYLEPHRINE;

AGED; AGING; ARTICLE; BLOOD PRESSURE; BRADYCARDIA; FEMALE; HEART RATE; MALE; NONHUMAN; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; RAT; SEX DIFFERENCE; TACHYCARDIA;

EID: 0343725829     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/0197-4580(95)02031-4     Document Type: Article

References (34)

1. Barringer, D.; Buñag, R. D. Differential anesthetic depression of chronotropic baroreflexes in rats. J. Cardiovasc. Pharmacol. 15:10-15; 1990.
2. Barringer, D.; Buñag, R. D. Autonomic regulation of reflex bradycardia in rats declines with age. Exp. Geront. 26:65-75; 1991.
3. Bruning, J. L.; Kintz, B. L. Computational Handbook of Statistics. Glenview, IL: Scott Foresman; 1987:18-109.
4. Buñag, R. D.; Eriksson, L.; Krizsan, D. Baroreceptor reflex impairment and mild hypertension in rats with dietary-induced obesity. Hypertension 15:397-406; 1990.
5. Buñag, R. D.; Krizsan, D.; Eriksson, L. Mediation of reflex tachycardia becomes exclusively β-adrenergic in old Fischer 344 rats. Mech. Age. Develop. 52:179-194; 1990.
6. Buñag, R. D.; Teravainen, T. Waning cardiovascular responses to adrenergic drugs in conscious ageing rats. Mech. Age. Develop. 61:313-326; 1991.
7. Buñag, R. D.; Teravainen, T. Tail-cuff detection of systolic hypertension in different strains of ageing rats. Mech. Age. Develop. 59:197-213; 1991.
8. Buñag, R. D.; Teravainen, T.; Eriksson, L. Enhanced sympathetic mediation of chronotropic baroreflexes in old Sprague-Dawley rats. Mech. Age. Develop. 53:195-208; 1990.
9. Buñag, R. D.; Walaszek, E.; Mueting N. Sex differences in reflex tachycardia induced by hypotcnsive drugs in unancsthetized rats. Am. J. Physiol. 229:652-656; 1975.
10. Coleman, G. L.; Barthold, S. W.; Osbaldiston, G. W.; Foster, S. J.; Jonas, A. M. Pathological changes during aging in barrier-reared Fischer 344 male rats. J. Geront. 23:21-36; 1983.
11. Cox, R. Age-related changes in arterial wall mechanics and composition of NIA Fischer rats. Mech. Age. Develop. 23:21-36; 1983.
12. Docherty, J.; Fitzgerald, D.; O'Malley, K. Age-related reduction of baroreflex tachycardia without loss of β-adrenoceptor-mediated tachycardia in Sprague-Dawley rats. J. Cardiovasc. Pharmacol. 8:376-380; 1986.
13. Ferrari, A. U.; Daffonchio A.; Albergati, F.; Mancia, G. Differential effects of aging on the heart rate and blood pressure influences of arterial baroreceptors in awake rats. J. Hypertension 9:615-621; 1991.
14. Fischer, G. M.; Swain, M. L. Effect of sex hormones on blood pressure and vascular connective tissue in castrated and noncastrated male rats. Am. J. Physiol. 232:H617-H621; 1977.
15. Fujita, H.; Chiba, M.; Ohta, M.; Kitani, K.; Suzuki, T. Alterations of plasma sex hormone levels associated with old age and its effect on hepatic drug metabolism in rats. J. Pharmacol. Exp. Ther. 253:369-374; 1990.
16. Greenburg, S.; George, W. R.; Kadowitz, P. J.; Wilson, W. R. Androgen-induced enhancement of vascular reactivity. Can. J. Physiol. Pharmacol. 52:14-22; 1974.
17. Hajduczok, G.; Chapleau, M. W.; Abboud, F. M. Rapid adaptation of central pathways explains the suppressed baroreflex with aging. Neuorobiol. Aging 12:601-604; 1991.
18. Hajduczok, G.; Chapleau, M. W.; Abboud, F. M. Increase in sympathetic activity with age II. Role of impairment of cardiopulmonary baroreflexes. Am. J. Physiol. 260:H1121-H1127; 1991.
19. Itoh, H.; Buñag, R. D. Age-related reduction of reflex bradycardia in conscious rats by catecholaminergic nucleus tractus solitarius lesions. Mech. Age. Develop. 67:47-63; 1993.
20. Kannel, W. B.; Doyle, J. T.; Ostfeld, A. M.; Jenkins, C. D.; Kuller, L.; Podell, R. N.; Stamler, J. Optimal resources for primary prevention of atherosclerotic diseases:Atherosclerosis Study Group. Circulation 70:157A-205A; 1984.
21. Kowaluk, E.; Seth, A. P.; Fung, H. L. Metabolic activation of sodium nitroprusside to nitric oxide in vascular smooth muscle. J. Pharmacol. Exp. Ther. 262:916-922; 1992.
22. Luscher, T. F.; Dohi, Y.; Tschudi, M. Endothelium-dependent regulation of resistance arteries: Alterations with aging and hypertension. J. Cardiovasc. Pharmacol. 19:s34-s42; 1992.
23. McCubbin, J. W.; Green, J. H.; Page, I. H. Baroreceptor function in chronic renal hypertension. Circ. Res. 4:205-212; 1956.
24. Mills, T. M.; Wiedmeier, V. T.; Stopper, V. S. Androgen maintenance of erectile function in the rat penis. Biol. Reprod. 46:342-348; 1992.
25. Nakamura, H.; Izumiyama, N.; Nakamura, K.; Ohtsubo, K. Age-associated ultrastructural changes in the aortic intima of rats with diet-induced hypercholesterolemia. Atherosclerosis 79:101-111; 1989.
26. Rothbaum, D.; Shaw, D.; Angell, C.; Shock, N. Age differences in the baroreceptor response of rats. J. Geront. 29:488-492; 1974.
27. Sasaki, S.; Yoneda, Y.; Fujita, H.; Uchida, A.; Takenaka, K.; Takesako, T.; Itoh, H.; Nakata, T.; Takeda, K.; Nakagawa, M. Association of blood pressure variability with induction of atherosclerosis in cholesterol-fed rats. Am. J. Hypertens. 7:453-459; 1994.
28. Takei, H.; Fredericks, W. R.; London, E. D.; Rapoport, S. I. Crebral blood flow and oxidative metabolism in conscious Fischer-344 rats of different ages. J. Neurochem. 40:801-805; 1983.
29. Tanabe, S.; Buñag, R. D. Age-related central and baroreceptor impairment in female Sprague-Dawley rats. Am. J. Physiol. 256: H1399-H1406; 1989.
30. Tanabe, S.; Buñag, R.D. Aging escalates baroreceptor reflex suppression by the posterior hypothalamus in rats. Hypertension 17:80-90; 1991.
31. Thomas, J.; Bertrand, H.; Stacy, C.; Herlihy, J. T. Long-term caloric restriction improves baroreflex sensitivity in aging Fischer 344 rats. J. Geront. 48:B151-B155; 1993.
32. Wei, J. Y.; Mendelowitz, D.; Anastasi, N.; Rowe, J. W. Influence of age on cardiovascular reflex response in anesthetized rats. Am. J. Physiol. 249:R31-R38; 1985.
33. Wei, J. Y.; Mendelowitz, D.; Anastasi, N.; Rowe, J. W. Maintenance of carotid baroreflex function in advanced age in the rat. Am. J. Physiol. 249:R31-R38; 1985.
34. Wexler, B. C. Spontaneous arteriosclerosis in old, male virgin Sprague-Dawley rats. Atherosclerosis 34:277-290; 1979.