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Volumn 41, Issue 11, 2000, Pages 1837-1840

A stepwise synthesis of triazine-based macrocyclic scaffolds

Author keywords

Combinatorial chemistry; Macrocycles; Scaffold; Triazines

Indexed keywords

MACROCYCLIC COMPOUND; TRIAZINE DERIVATIVE;

EID: 0343674738     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(00)00027-7     Document Type: Article
Times cited : (26)

References (20)
  • 2
    • 0033617124 scopus 로고    scopus 로고
    • (a) For some recent examples of unsymmetrically substituted macrocycles, see:
    • (a) Rasmussen, P. H.; Rebek Jr., J. Tetrahedron Lett. 1999, 40, 3511-3514.
    • (1999) Tetrahedron Lett. , vol.40 , pp. 3511-3514
    • Rasmussen, P.H.1    Rebek J., Jr.2
  • 7
    • 0342952223 scopus 로고    scopus 로고
    • Minimized using Quanta 97. MSI, 9685 Scranton Road, San Diego, CA 92121-3752
    • Minimized using Quanta 97. MSI, 9685 Scranton Road, San Diego, CA 92121-3752, 1996.
    • (1996)
  • 8
    • 0343387659 scopus 로고    scopus 로고
    • The synthesis of larger macrocycles was also investigated. Repetition of the elongation and functionalisation steps on compound 10b afforded the precursors for the tetra-, penta- and hexatriazine-piperazine macrocycles, which were cyclised into their corresponding scaffolds. In addition, ethylenediamine and xylene were used as spacers. These results will be reported elsewhere. See also Ref. 10.
    • The synthesis of larger macrocycles was also investigated. Repetition of the elongation and functionalisation steps on compound 10b afforded the precursors for the tetra-, penta- and hexatriazine-piperazine macrocycles, which were cyclised into their corresponding scaffolds. In addition, ethylenediamine and xylene were used as spacers. These results will be reported elsewhere. See also Ref. 10.
  • 11
    • 37049127787 scopus 로고
    • Koopman, H.; Daams, J. Rec. Trav. Chim. Pays-Bas 1958, 77, 235-240. See also: Beech, W. F. J. Chem. Soc. C 1967, 466-472.
    • (1967) J. Chem. Soc. C , pp. 466-472
    • Beech, W.F.1
  • 14
    • 0342518040 scopus 로고    scopus 로고
    • Compound 8a was also subjected to subsequent hydrogenolysis and a reaction with cyanuric chloride to afford the corresponding dichloride. However, we were not able to cyclise this precursor to the cyclic bistriazine.
    • Compound 8a was also subjected to subsequent hydrogenolysis and a reaction with cyanuric chloride to afford the corresponding dichloride. However, we were not able to cyclise this precursor to the cyclic bistriazine.
  • 15
    • 0342518039 scopus 로고    scopus 로고
    • High and low temperature NMR experiments showed that possibly the macrocyclic ring is able to invert at room temperature. However, if this does not occur, the unsymmetrically substituted trimers will be produced as a racemic mixture.
    • High and low temperature NMR experiments showed that possibly the macrocyclic ring is able to invert at room temperature. However, if this does not occur, the unsymmetrically substituted trimers will be produced as a racemic mixture.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.