Distribution of the receptor-anchoring protein gephyrin in the rat dentate gyrus and changes following entorhinal cortex lesion

Cerebral Cortex

Volumn 10, Issue 4, 2000, Pages 422-432

  Simburger E ^b   Plaschke, M ^b   Kirsch, J ^a   Nitsch, Robert ^b,c  

^a UNIVERSITY OF ULM   (Germany)

^b HUMBOLDT UNIVERSITY   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GEPHYRIN; PARVALBUMIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN INJURY; CONTROLLED STUDY; DENDRITE; DENTATE GYRUS; ENTORHINAL CORTEX; GRANULE CELL; IMMUNOREACTIVITY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; SYNAPSE; SYNAPTOGENESIS;

EID: 0343674529     PISSN: 10473211     EISSN: None     Source Type: Journal    
DOI: 10.1093/cercor/10.4.422     Document Type: Article

References (48)

1. Alvarez FJ, Dewey DE, Harrington DA, Fyffe RE (1997) Cell-type specific organization of glycine receptor clusters in the mammalian spinal cord. J Comp Neurol 379:150-170.
2. Amaral DG, Witter MP (1995) Hippocampal formation. In: The rat nervous system (Paxinos G ed.), pp. 443-493. Sydney: Academic Press.
3. Araki T, Yamano M, Murakami T, Wanaka A, Betz H, Tohyama M (1988) Localization of glycine receptors in the rat central nervous system: an immunocytochemical analysis using monoclonal antibody. Neuroscience 25:613-624.
4. Celio MR (1990) Calbindin D-28k and parvalbumin in the rat nervous system. Neuroscience 35:375-475.
5. Clusmann H, Nitsch R, Heinemann U (1994) Long lasting functional alterations in the rat dentate gyrus following entorhinal cortex lesion: a current source density analysis. Neuroscience 61:805-815.
6. Colin I, Rostaing P, Augustin A, Triller A (1998) Localization of components of glycinergic synapses during rat spinal cord development. J Comp Neurol 398:359-372.
7. Craig AM, Banker G, Chang W, McGrath ME, Serpinskaya AS (1996) Clustering of gephyrin at GABAergic but not glutamatergic synapses in cultured rat hippocampal neurons. J Neurosci 16:3166-3177.
8. Deller T (1998) The anatomical organization of the rat fascia dentata: new aspects of laminar organization as revealed by anterograde tracing with Phaseolus vulgaris-leucoagglutinin (PHAL). Anat Embryol 197:89-103.
9. Deller T, Nitsch R, Frotscher M (1995a) Phaseolus vulgaris-leucoagglutinin tracing of commissural fibers to the rat dentate gyrus: evidence for a previously unknown commissural projection to the outer molecular layer. J Comp Neurol 352:55-68.
10. Deller T, Frotscher M, Nitsch R (1995b) Morphological evidence for the sprouting of inhibitory commissural fibers in response to the lesion of the excitatory entorhinal input to the rat dentate gyrus. J Neurosci 15:6868-6878.
11. 2 subunit and gephyrin. Nature Neurosci 1:563-571.
12. Freund TF, Buzsáki G (1996) Interneurons of the hippocampus. Hippocampus 6:347-470.
13. A receptor heterogeneity in the adult rat brain: differential regional and cellular distribution of seven major subunits. J Comp Neurol 359:154-194.
14. A receptors containing the α1 subunit to neurochemically distinct subpopulations of rat hippocampal interneurons. Eur J Neurosci 6:837-853.
15. Gazzaley AH, Benson DL, Huntley GW, Morrison JH (1997) Differential subcellular regulation of NMDAR1 protein and mRNA in dendrites of dentate gyrus granule cells after perforant path transection. J Neurosci 17:2006-2017.
16. Geddes JW, Hess EJ, Hart RA, Kesslak JP, Cotman CW, Wilson MC (1990) Lesions of hippocampal circuitry define synaptosomal-associated protein-25 (SNAP-25) as a novel presynaptic marker. Neuroscience 38:515-525.
17. Germroth P, Schwerdtfeger WK, Buhl EH (1989) GABAergic neurons in the entorhinal cortex project to the hippocampus. Brain Res 494:187-192.
18. Germroth P, Schwerdtfeger WK, Buhl EH (1991) Ultrastructure and aspects of functional organization of pyramidal and nonpyramidal entorhinal projection neurons contributing to the perforant path. J Comp Neurol 305:215-231.
19. Giustetto M, Kirsch J, Fritschy J-M, Cantino D, Sassoè-Pognetto M (1998) Localization of the clustering protein gephyrin at GABAergic synapses in the main olfactory bulb of the rat. J Comp Neurol 395:231-244.
20. Goldowitz D, Vincent SR, Wu JK, Hokfelt T (1982) Immunohistochemical demonstration of plasticity in GABA neurons of the adult rat dentate gyrus. Brain Res 238:413-420.
21. Halasy K, Somogyi P (1993) Subdivisions in the multiple GABAergic innervation of granule cells in the dentate gyrus of the rat hippocampus. Eur J Neurosci 5:411-429.
22. Kirsch J, Betz H (1993) Widespread expression of gephyrin, a putative glycine receptor-tubulin linker protein, in rat brain. Brain Res 621:301-310.
23. Kirsch J, Betz H (1995) The postsynaptic localization of the glycine receptor-associated protein gephyrin is regulated by the cytoskeleton. J Neurosci 15:4148-4156.
24. Kirsch J, Betz H (1998) Glycine-receptor activation is required for receptor clustering in spinal neurons. Nature 392:717-720.
25. Kirsch J, Langosch D, Prior P, Littauer UZ, Schmitt B, Betz H (1991) The 93-kDa glycine receptor-associated protein binds to tubulin. J Biol Chem 266:22242-22245.
26. Kirsch J, Wolters I, Triller A, Betz H (1993) Gephyrin antisense oligonucleotides prevent glycine receptor clustering in spinal neurons. Nature 366:745-748.
27. Lim R, Alvarez FJ, Walmsley B (1999) Quantal size is correlated with receptor cluster area at glycinergic synapses in the rat brainstem. J Physiol 516:505-512.
28. Lynch G, Matthews DA, Mosko S, Parks T, Cotman C (1972) Induced acetylcholinesterase-rich layer in rat dentate gyrus following entorhinal lesions. Brain Res 42:311-318.
29. Masliah E, Fagan AM, Terry RD, DeTeresa R, Mallory M, Gage FH (1991) Reactive synaptogenesis assessed by synaptophysin immunoreactivity is associated with GAP-43 in the dentate gyrus of the adult rat. Exp Neurol 113:131-142.
30. Matthews DA, Cotman C, Lynch G (1976a) An electron microscopic study of lesion-induced synaptogenesis in the dentate gyrus of the adult rat. I. Magnitude and time course of degeneration. Brain Res 115:1-21.
31. Matthews DA, Cotman C, Lynch G (1976b) An electron microscopic study of lesion-induced synaptogenesis in the dentate gyrus of the adult rat. II. Reappearance of morphologically normal synaptic contacts. Brain Res 115:23-41.
32. Melloni RH Jr, Apostolides PJ, Hamos JE, DeGennaro LJ (1994) Dynamics of synapsin I gene expression during the establishment and restoration of functional synapses in the rat hippocampus. Neuroscience 58:683-703.
33. Mesulam MM, Geula C, Moran MA (1987) Anatomy of cholinesterase inhibition in Alzheimer's disease: effect of physostigmine and tetrahydroaminoacridine on plaques and tangles. Ann Neurol 22:683-691.
34. Meyer G, Kirsch J, Betz H, Langosch D (1995) Identification of a gephyrin binding motif on the glycine receptor β subunit Neuron 15:563-572.
35. 2/3 immunoreactivity in the dentate gyrus after perforant pathway lesion. Neuroreport 8:3379-3383.
36. Nadler JV, Cotman CW, Paoletti C, Lynch GS (1977) Histochemical evidence of altered development of cholinergic fibers in the rat dentate gyrus following lesions. II. Effects of partial entorhinal and simultaneous multiple lesions. J Comp Neurol 171:589-604.
37. A receptor subunit polypeptides increase in parallel but exhibit distinct distributions in the developing rat cerebellum. J Neurobiol 25:1533-1544.
38. Nitsch R, Klauer G (1989) Cryostat sections for coexistence studies and preembedding electron microscopic immunocytochemistry of central and peripheral nervous system tissue. Histochemistry 92:459-465.
39. Paxinos G, Watson C (1986) The rat brain in stereotaxic coordinates. Sydney: Academic Press.
40. Pfeiffer F, Simler R, Grenningloh G, Betz H (1984) Monoclonal antibodies and peptide mapping reveal structural similarities between the subunits of the glycine receptor of rat spinal cord. Proc Natl Acad Sci USA 81:7224-7227.
41. Ruth RE, Collier TJ, Routtenberg A (1982) Topography between the entorhinal cortex and the dentate septotemporal axis in rats: I. Medial and intermediate entorhinal projecting cells. J Comp Neurol 209:69-78.
42. Ruth RE, Collier TJ, Routtenberg A (1988) Topographical relationship between the entorhinal cortex and the septotemporal axis of the dentate gyrus in rats: II. Cells projecting from lateral entorhinal subdivisions. J Comp Neurol 270:506-516.
43. Sampedro MN, Bussineau CM, Cotman CW (1982) Turnover of brain postsynaptic densities after selective deafferentiation: detection by means of an antibody to antigen PSD-95. Brain Res 251:211-220.
44. A receptors, and the anchoring protein gephyrin. J Comp Neurol 381:158-174.
45. A receptor subunits in the rat hippocampus I: immunocytochemical distribution of 13 subunits Neuroscience 80:987-1000.
46. Steward O, Vinsant SL (1983) The process of reinnervation in the dentate gyrus of the adult rat: a quantitative electron microscopic analysis of terminal proliferation and reactive synaptogenesis. J Comp Neurol 214:370-386.
47. van den Pol AN, Gorcs T (1988) Glycine and glycine receptor immunoreactivity in brain and spinal cord. J Neurosci 8:472-492.
48. Zipp F, Nitsch R, Soriano E, Frotscher M (1989) Entorhinal fibers form synaptic contacts on parvalbumin-immunoreactive neurons in the rat fascia dentata. Brain Res 495:161-166.