Differential agonist-induced desensitization of P2Y2 nucleotide receptors by ATP and UTP

Molecular and Cellular Biochemistry

Volumn 206, Issue 1-2, 2000, Pages 75-89

  Velázquez, Betty ^a   Garrad, Richard C ^b   Weisman, Gary A ^b   González, Fernando A ^a  

^a UNIVERSITY OF PUERTO RICO   (Puerto Rico)

^b University of Missouri   (United States)

Author keywords

Individual cell measurements; Intracellular calcium mobilization; P2 nucleotide receptors; Receptor desensitization

Indexed keywords

ADENOSINE TRIPHOSPHATE; FURA 2 ACETOXYMETHYL ESTER; G PROTEIN COUPLED RECEPTOR; PURINE P2Y RECEPTOR; PURINERGIC RECEPTOR STIMULATING AGENT; RECEPTOR SUBTYPE; RECOMBINANT RECEPTOR; URIDINE TRIPHOSPHATE;

ANIMAL CELL; ARTICLE; ASTROCYTOMA CELL; CALCIUM MOBILIZATION; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; HUMAN; HUMAN CELL; MAMMAL CELL; MOUSE; NONHUMAN; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION;

ANIMALIA; MAMMALIA; MURINAE;

EID: 0343673835     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/a:1007091127392     Document Type: Article

References (34)

1. Turner JT, Weisman GA, Fedan JS: The P2 Nucleotide Receptors. Humana Press, Totowa, NJ, 1998
2. Weisman GA, Gonzalez FA, Erb L, Garrad RC, Turner JT: The cloning and expression of G protein-coupled P2Y nucleotide receptors. In: J.T. Turner, G.A. Weisman, J.S. Fedan (eds). The P2 Nucleotide Receptors, Humana Press, Totowa, NJ, 1998, pp 63-79
3. Lustig KD, Shiau AK, Brake AJ, Julius D: Expression cloning of an ATP receptor from mouse neuroblastoma cells. Proc Natl Acad Sci USA 90: 5113-5117, 1993
4. 2U nucleotide receptor: A target for cystic fibrosis pharmacotherapy. Proc Natl Acad Sci USA 91: 3275-3279, 1994
5. Gonzalez FA, Gross DJ, Heppel LA, Webb WW: Studies on the increase in cytosolic free calcium induced by epidermal growth factor, serum, and nucleotides in individual A431 cells. J Cell Physiol 135: 269-276, 1988
6. Gonzalez FA, Heppel LA, Gross DJ, Webb WW, Parries G: The rapid desensitization of receptors for platelet derived growth factor, bradykinin and ATP: Studies on individual cells using quantitative digital video microscopy. Biochem Biophys Res Commun 151: 1205-1212, 1988
7. 2Y-purinergic receptor-regulated phospholipase C. J Biol Chem 264: 19535-19539, 1989
8. Suter MM, Crameri FM, Slattery JP, Millard PJ, Gonzalez FA: Extracellular ATP and some of its analogs induce transient rises in cytosolic free calcium in individual canine keratinocytes. J Invest Dermatol 97: 223-229, 1991
9. 2Y purinoceptors and nucleotide receptors) coexisting on endothelial cells. Mol Pharmacol 45: 731-736, 1994
10. 2U receptors in single human gastric mucous cells. Biochem Biophys Res Commun 216: 637-641, 1995
11. 2+ responses. Biochem J 320: 215-219, 1996
12. Knowles MR, Clarke LL, Boucher RC: Activation by extracellular nucleotides of chloride secretion in the airway epithelia of patients with cystic fibrosis. N Engl J Med 325: 533-538, 1991
13. Knowles MR, Clarke LL, Boucher RC: Extracellular ATP and UTP induce chloride secretion in nasal epithelia of cystic fibrosis patients and normal subjects in vivo. Chest 101: 60S-63S, 1992
14. Stutts MJ, Chinet TC, Mason SJ, Fulton JM, Clarke LL, Boucher RC: Regulation of chloride channels in normal and cystic fibrosis airway epithelial cells by extracellular ATP. Proc Natl Acad Sci USA 89: 1621-1625, 1992
15. 2 nucleotide receptors in cystic fibrosis (CF) epithelium. Adv Exp Med Biol 431: 417-424, 1998
16. 2 receptor-activated transepithelial anion secretion. Am J Physiol 276: C777-C787, 1999
17. 2+ and cAMP levels by protein kinase C. Mol Pharmacol 44: 1185-1191, 1994
18. Matsuoka I, Zhou Q, Ishimoto H, Nakanishi H: Extracellular ATP stimulates adenylyl cyclase and phospholipase C through distinct purinoceptors in NG108-15 cells. Mol Pharmacol 47: 855-862, 1995
19. 7 (P2Z) receptor in N18TG-2 cells and NG108-15 cells. J Neurochem 70: 951-957, 1998
20. 2 purinoceptors: Positively charged amino acids in transmembrane helices 6 and 7 affect agonist potency and specificity. J Biol Chem 270: 4185-4188, 1995
21. 2 nucleotide receptor: Consequences of truncation of the C-terminus. J Biol Chem 273: 29437-29444, 1998
22. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 260: 3440-3450, 1985
23. 2U purinergic receptor. Proc Natl Acad Sci USA 90: 10449-10453, 1993
24. 2+ in individual stimulated tumor mast cells. Proc Natl Acad Sci USA 85: 1854-1858, 1988
25. 2+ changes in human lung mast cells: Graded vs. all-or-nothing elevations after IgE-mediated stimulation. J Cell Biol 109: 123-134, 1989
26. Mahama PA, Linderman JJ: Calcium signaling in individual BC3H1 cells: Speed of calcium mobilization and heterogeneity. Biotechnol Prog 10: 45-54, 1994
27. Agrawal NGB, Linderman JJ: Calcium response of helper T lymphocytes to antigen-presenting cells in a single-cell assay. Biophys J 69: 1178-1190, 1995
28. 2+ responses of RBL-2H3 mast cells. Mol Biol Cell 6: 825-839, 1995
29. 2+ response heterogeneity at the single-cell level. J Cell Physiol 166: 643-652, 1996
30. 2+ fluxes in A431 cells. J Cell Physiol 141: 606-617, 1989
31. Kurihara K, Hosoi K, Ueha T: Characterization of ecto-nucleoside triphosphate on A-431 human epidermoidal carcinoma cells. Enzyme 46: 213-220, 1992
32. Lazarowski ER, Homolya L, Boucher RC, Harden TK: Identification of an ecto-nucleoside diphosphokinase and its contribution to interconversion of P2 receptor agonists. J Biol Chem 272: 20402-20407, 1997
33. Freedman NJ, Lefkowitz RJ: Desensitization of G protein-coupled receptors. Recent Prog Horm Res 51: 319-351, 1996
34. Oppermann M, Freedman NJ, Alexander RW, Lefkowitz RJ: Phosphorylation of the type 1A angiotensin II receptor by G protein-coupled receptor kinases and protein kinase C. J Biol Chem 271: 13266-13272, 1996