Application of similarity matrices and genetic neural networks in qualitative structure-activity relationships of 2- or 4-(4- methylpiperazino)pyrimidines: 5-HT(2A) receptor antagonists

Journal of Medicinal Chemistry

Volumn 43, Issue 10, 2000, Pages 1901-1909

  Borowski, Tomasz ^a   Król, Marcin ^a   Brocławik, Ewa ^b   Baranowski, Timothy C ^c   Strekowski, Lucjan ^c   Mokrosz, Maria J ^a  

^a JAGIELLONIAN UNIVERSITY   (Poland)

^b INSTITUTE OF CATALYSIS AND SURFACE CHEMISTRY   (Poland)

^c GEORGIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 METHYLPIPERAZINO)PYRIMIDINE; PYRIMIDINE DERIVATIVE; SEROTONIN ANTAGONIST; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONFORMATIONAL TRANSITION; CRYSTALLIZATION; CYTOARCHITECTURE; LIGAND BINDING; LIPID BILAYER; NERVE CELL NETWORK; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RECEPTOR AFFINITY;

ANIMALS; BINDING, COMPETITIVE; CEREBRAL CORTEX; CLOZAPINE; KETANSERIN; LIGANDS; MATHEMATICS; MODELS, CHEMICAL; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; NEURAL NETWORKS (COMPUTER); PYRIMIDINES; RATS; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, SEROTONIN; SEROTONIN ANTAGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0343618623     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9911332     Document Type: Article

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