In vitro competitive inhibition of plasma cholinesterase by cocaine: Normal and variant genotypes

Journal of Toxicology - Clinical Toxicology

Volumn 34, Issue 1, 1996, Pages 77-81

  Schwartz, Hardy J ^a   Johnson, David ^a,b  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b ALBERTA CHILDREN'S HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINESTERASE; COCAINE;

ARTICLE; CHOLINESTERASE INHIBITION; COMPETITIVE INHIBITION; CONTROLLED STUDY; GENOTYPE; HUMAN; IN VITRO STUDY; SERUM;

EID: 0343598065     PISSN: 07313810     EISSN: None     Source Type: Journal    
DOI: 10.3109/15563659609020237     Document Type: Article

References (16)

1. Inaba T. Cocaine: pharmacokinetics and biotransformation in man. Can J Physiol Pharmacol 1989;67: 1154-1157.
2. Stewart DJ, Inaba T, Tang BK, Kalow W. Hydrolysis of cocaine in human plasma by cholinesterase. Life Sci 1977;20:1557-1563.
3. Stewart DJ, Inaba T, Lucassen M, Kalow W. Cocaine metabolism: cocaine and norcocaine hydrolysis by liver and serum esterases. Clin Pharmacol Ther 1979;25:464-468.
4. Huffman RS, Henry GC, Howland MA, Weisman RS, Weil L, Goldfrank LR. Association between life-threatening cocaine toxicity and plasma cholinesterase activity. Ann Emerg Med 1992;21: 247-253.
5. Om A, Ellahham S, Ornato JP, et al. Medical complications of cocaine: possible relationship to low plasma cholinesterase enzyme. Am Heart J 1993;125: 1114-1117.
6. Devenyi P. Cocaine complications and pseudocholinesterase. Ann Intern Med 1989;110:167-168.
7. Kalow W, Genest K. A method for the detection of atypical forms of human serum cholinesterase. Determination of dibucaine numbers. Can J Biochem Physiol 1957;35:339-346.
8. Harris H, Whittaker M. Differential inhibition of human serum cholinesterase with fluoride: Recognition of two new phenotypes. Nature 1961; 191:496-498.
9. La Du BN, Bartels CF, Nogueira CP, et al. Phenotypic and molecular biological analysis of human butyrylcholinesterase variants. Clin Biochem 1990;23:423-431.
10. Dietz AA, Rubinstein HM, Lubrano T. Colorimetric determination of serum cholinesterase and its genetic variants by the propionylthiocholine-dithiobis (nitrobenzoic acid) procedure. Clin Chem 1973;19: 1309-1313.
11. Kambam JR, Naukam R, Berman ML. Inhibition of pseudocholinesterase activity protects from cocaine-induced cardiorespiratory toxicity in rats. J Lab Clin Med 1992;119:553-556.
12. Kambam I, Mets B, Hickman R, James P, James MF, Kirsch R. The effects of inhibition of plasma cholinesterase activity on systemic toxicity and blood catechotamine levels from cocaine infusion in pigs. J Lab Clin Med 1993;122:188-196.
13. Hoffman RS, Henry GC, Wax PM, Weisman RS, Howland MA, Goldfrank LR. Decreased plasma cholinesterase activity enhances cocaine toxicity in mice. J Pharmacol Exp Ther 1992;263:698-702.
14. Hoffman RS, Morasco R, Goldtrank LR. Human plasma cholinesterase protects against cocaine toxicity in mice. Vet Hum Toxicol 1993;35:349a.
15. Johns ME, Henderson RL. Cocaine use by the otolaryngologist: a survey. Trans Am Acad Ophthalmol Otolaryngol 1977;84:969-973.
16. Feehan HF, Mancusi-Ungaro A. The use of cocaine as a topical anesthetic in nasal surgery. A survey report. Plast Reconstr Surg 1976;57:62-65.