Hypoxic excitation in neurons cultured from the rostral ventrolateral medulla of the neonatal rat

Journal of Applied Physiology

Volumn 88, Issue 6, 2000, Pages

  Mazza Jr , Emilio ^a   Edelman, Norman H ^b   Neubauer, Judith A ^a  

^a ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b STONY BROOK UNIVERSITY   (United States)

Author keywords

Respiratory; Sodium cyanide; Sympathetic; Whole cell perforated patch clamp

Indexed keywords

CALCIUM ION; CATION CHANNEL; MAGNESIUM ION; SODIUM CYANIDE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; HYPERPOLARIZATION; HYPOXIA; MEDULLA OBLONGATA; NERVE CELL MEMBRANE CONDUCTANCE; NERVE CELL MEMBRANE POTENTIAL; NERVE CELL STIMULATION; NEWBORN; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; SYMPATHETIC NERVE;

EID: 0343517079     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.2000.88.6.2319     Document Type: Article

References (52)

1. Alcayaga J, Varas R, Arroyo J, Iturriaga R, and Zapata P. Responses to hypoxia of petrosal ganglia in vitro. Brain Res 845: 28-34, 1999.
2. Bayliss DA, Viana F, Bellingham MC, and Berger AJ. Characteristics and postnatal development of a hyperpolarization-activated inward current in rat hypoglossal motoneurons in vitro. J Neurophysiol 11: 119-128, 1994.
3. Buckler KJ and Vaughan-Jones RD. Effects of hypoxia on membrane potential and intracellular calcium in rat neonatal carotid body type I cells. J Physiol (Lond) 476: 423-428, 1994.
4. Butera, RJ Jr, Rinzel J, and Smith JC. Models of respiratory rhythm generation in the pre-Botzinger complex. I. Bursting pacemaker neurons. J Neurophysiol 82: 382-397, 1999.
5. Butera, RJ Jr, Rinzel J, and Smith JC. Models of respiratory rhythm generation in the pre-Botzinger complex. II. Populations of coupled pacemaker neurons. J Neurophysiol 82: 398-415, 1999.
6. Chae LO, Melton JE, Neubauer JA, and Edelman NH. Phrenic and sympathetic nerve responses to glutamergic blockade during normoxia and hypoxia. J Appl Physiol 74: 1954-1963, 1993.
7. 2 sensor protein in the rat carotid body. Biochem J 272: 743-747, 1990.
8. Cummins TR, Donnelly DF, and Haddad GG. Effect of metabolic inhibition on the excitability of isolated hippocampal CAl neurons: developmental aspects. J Neurophysiol 66: 1471-1482, 1991.
9. Cummins TR, Jiang C, and Haddad GG. Human neocortical excitability is decreased during anoxia via sodium channel modulation. J Clin Invest 91: 608-615, 1993.
10. Dawes GS, Gardner WN, Johnston BM, and Walker DW. Breathing in fetal lambs: the effect of brainstem section. J Physiol (Lond) 335: 535-553, 1983.
11. Dillon GH and Waldrop TG. In vitro response of caudal hypothalamic neurons to hypoxia and hypercapnia. Neuroscience 51: 941-950, 1992.
12. Duchen MR. Effects of metabolic inhibition on the membrane properties of isolated mouse primary sensory neurones. J Physiol (Lond) 424: 387-409, 1990.
13. Duchen MR and Biscoe TJ. Mitochondrial function in type I cells isolated from rabbit arterial chemoreceptors. J Physiol (Lond) 450: 13-31, 1992.
14. Ellenhorn MJ and Barceloux DG. Cyanide. In: Medical Toxicology. Diagnosis and Treatment of Human Poisoning. New York: Elsevier, 1988, p. 829-835.
15. Erdemili G and Crunelli V. Response of thalamocortical neurons to hypoxia: a whole-cell patch-clamp study. J Neurosci 18: 5212-5224, 1998.
16. Feldman JL and Smith JC. Neural control of respiratory pattern in mammals: an overview. In: Regulation of Breathing, edited by Dempsey JA and Pack AI. New York: Dekker, 1995.
17. Fujiwara N, Higashi H, Shimoji K, and Yoshimura M. Effects of hypoxia on rat hippocampal neurones in vitro. J Physiol (Lond) 384: 131-151, 1987.
18. Fujiwara N, Tanaka E, Yamamoto S, Shigemori M, and Higashi H. Contribution of ATP-sensitive potassium channels to hypoxic hyperpolarization in rat hippocampal CAl neurons in vitro. J Neurophysiol 77: 378-385, 1997.
19. Gonzalez C, Almaraz L, Obeso A, and Rigual R. Carotid body chemoreceptors: from natural stimuli to sensory discharges. Physiol Rev 74: 829-898, 1994.
20. Guntheroth WG and Kawabori I. Hypoxic apnea and gasping. J Clin Invest 56: 1371-1377, 1975.
21. 2+ of the hyperpolarization-activated inward currents in rabbit single sino-atrial node-cells. J Physiol (Lond) 409: 121-141, 1989.
22. Horn R and Marty A. Muscarinic activation of ionic current measured by a new whole-cell recording method. J Gen Physiol 92: 145-159, 1988.
23. h) cyclic nucleotides in guinea-pig afferent neurons. J Physiol (Lond) 494: 97-106, 1996.
24. Kay AR and Wong KS. Isolation of neurons suitable for patch-clamping from adult mammalian central nervous systems. J Neurosci Methods 16: 227-238, 1986.
25. Leblond J and Krnjevic K. Hypoxic changes in hippocampal neurons. J Neurophysiol 62: 1-14, 1989.
26. Lewis R, Ross P, and Cahalan M. Chloride channels activated by osmotic stress in T lymphocytes. J Gen Physiol 101: 801-826, 1993.
27. Lopez-Barneo J. Oxygen-sensing by ion channels and the regulation of cellular functions. Trends Neurosci 19: 435-440, 1996.
28. 2 in type I chemoreceptor cells. Science 241: 580-582, 1988.
29. Mazza E and Neubauer JA. Electrophysiological response to hypoxia after inhibition of heme oxygenase in neurons cultured from the rostral ventrolateral medulla (Abstract). FASEB J 12: A497, 1998.
30. McCarthy KD and DeVellis J. Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. J Cell Biol 85: 890-902, 1980.
31. Melton JE, Chae LO, Neubauer JA, and Edelman NH. Extracellular potassium homeostasis in the cat medulla during progressive brain hypoxia. J Appl Physiol 70: 1477-1482, 1991.
32. Millhorn DE and Eldridge FL. Role of ventrolateral medulla in regulation of respiratory and cardiovascular systems. J Appl Physiol 61: 1249-1263, 1986.
33. Mills E and Jöbsis FF. Simultaneous measurement of cytochrome 33 reduction and chemoreceptor afferent activity in the carotid body. Nature 225: 1147-1149, 1970.
34. Mills E and Jöbsis FF. Mitochondrial respiratory chain of carotid body and chemoreceptor response to changes in oxygen tension. J Neurophysiol 35: 405-428, 1972.
35. Mitra J, Dev NB, Romaniuk JR, Trivedi R, Prabhakar NR, and Cherniak NS. Cardiorespiratory changes induced by vertebral artery injection of sodium cyanide in cats. Respir Physiol 87: 49-61, 1992.
36. Murphy KPSJ and Greenfield SA. Neuronal selectivity of ATP-sensitive potassium channels in guinea pig substantia nigra neurons revealed by response to anoxia. J Physiol (Lond) 453: 167-183, 1992.
37. Neubauer JA, Melton JE, and Edelman NH. Modulation of respiration during brain hypoxia. J Appl Physiol 68: 441-451, 1990.
38. Nieber K, Sevcik J, and Iles P. Hypoxic changes in rat locus coeruleus neurons in vitro. J Physiol (Lond) 486: 33-46, 1995.
39. Nolan PC and Waldrop TG. In vivo and in vitro responses of neurons in the ventrolateral medulla to hypoxia. Brain Res 630: 101-114, 1993.
40. O'Malley E, Black I, and Dreyfus C. Local support cells promote survival of substantia nigra dopaminergic neurons in culture. Exp Neurol 112: 40-48, 1991.
41. Pape H. Queer current and pacemaker: the hyperpolarization-activated cation current in neurons. Annu Rev Physiol 58: 299-327, 1996.
42. Paxinos G and Watson C. The Rat Brain in Sterotaxic Coordinates. San Diego, CA: Academic, 1997.
43. Piantadosi CA, Sylvia AL, and Jöbsis-Vandervliet FF. Differences in brain cytochrome responses to carbon monoxide and cyanide in vivo. J Appl Physiol 62: 1277-1284, 1987.
44. Prabhakar NR, Dinerman JL, Agani FH, and Synder SH. Carbon monoxide: a role in carotid body chemoreception. Proc Natl Acad Sci USA 32; 1994-1997, 1995.
45. Smith JC, Ellenberger HH, Ballanyi K, Richter DW, and Feldman JL. Pre-Bötzinger complex: a brainstem region that may generate respiratory rhythm in mammals. Science 254: 726-729, 1991.
46. Solomon IC, Edelman NH, and Neubauer JA. Patterns of phrenic motor output evoked by chemical stimulation of neurons located in the pre-Bötzinger complex in vivo. J Neurophysiol 81: 1150-1161, 1999.
47. Solomon IC, Melton JE, Edelman NH, and Neubauer JA. Chemical stimulation in the pre-Bötzinger region produces an augmented or gasp-like pattern in the phrenic neurogram in cats (Abstract). FASEB J 9: A667, 1995.
48. Sun MK, Jeske IT, and Reis DJ. Cyanide excites medullary sympathoexcitatory neurons in rats. Am J Physiol Regulatory Integrative Comp Physiol 262: R182-R189, 1992.
49. Sun MK and Reis DJ. Hypoxia selectively excites vasomotor neurons of rostral ventrolateral medulla. Am J Physiol Regulatory Integrative Comp Physiol 266: R245-R256, 1994.
50. 2+ currents in pacemaker neurones of rat rostral ventrolateral medulla in vitro. J Physiol (Lond) 476: 101-116, 1994.
51. Wasicko MJ, Melton JE, Neubauer JA, Krawciw N, and Edelman NH. Cervical sympathetic and phrenic nerve responses to progressive brain hypoxia. J Appl Physiol 68: 53-58, 1990.
52. 3 of the mitochondrial respiratory chain. FEBS Lett 351: 370-374, 1994.