No loss of biomechanical effects after withdrawal of short-term PTH treatment in an aged, osteopenic, ovariectomized rat model

Bone

Volumn 20, Issue 5, 1997, Pages 429-437

  Thomsen, J S ^a   McOsker, J E ^b   Mosekilde, Lis ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b PROCTER AND GAMBLE PHARMACEUTICALS   (United States)

Author keywords

Bisphosphonate; Bone mass; Bone strength; Osteopenia; Ovariectomy; PTH; Rat model

Indexed keywords

PARATHYROID HORMONE[1-34]; RISEDRONIC ACID; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BONE MASS; BONE STRENGTH; CONTROLLED STUDY; CORTICAL BONE; DRUG EFFECT; FEMALE; FEMUR; FEMUR NECK; NONHUMAN; OSSIFICATION; OSTEOPENIA; OVARIECTOMY; RAT; SUBCUTANEOUS DRUG ADMINISTRATION; VERTEBRA BODY;

AGING; ANIMALS; BIOMECHANICS; BONE AND BONES; BONE DISEASES, METABOLIC; CALCIUM CHANNEL BLOCKERS; DRUG ADMINISTRATION SCHEDULE; ETIDRONIC ACID; FEMALE; OVARIECTOMY; OVARY; PARATHYROID HORMONE; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

EID: 0343487705     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S8756-3282(97)00024-0     Document Type: Article

References (38)

1. Conover, W. J. Practical nonparametric statistics. New York: Wiley; 1980; 229-237.
2. Ejersted, C., Andreassen, T. T., Oxlund, H., Jergensen, P. H., Bak, B., Häggblad, J., Tørring, O., and Nilsson, M. H. L. Human parathyroid hormone (1-34) and (1-84) increase the mechanical strength and thickness of cortical bone in rats. J Bone Miner Res 9:1097-1101; 1993.
3. Gasser, J. A. and Jerome, C. P. Parathyroid hormone: A cure for osteoporosis? Triangle 31:111-121; 1992.
4. Gunness-Hey, M. and Hock, J. M. Increased trabecular bone mass in rats treated with human synthetic parathyroid hormone. Metab Bone Dis Rel Res 5:177-181; 1984.
5. Gunness-Hey, M. and Hock, J. M. Loss of anabolic effect of parathyroid hormone on bone after discontinuation of hormone in rats. Bone 10:447-452; 1989.
6. Harris, S. T., Genant, H. K., Baylink, D. J., Gallagher, J. C., Karp, S. K., McConnell, M. A., Green, E. M., and Stoll, R. W. The effects of estrogen on spinal bone density of postmenopausal women. Arch Intern Med 151:1980-1984; 1991.
7. Hefti, E., Trechsel, U., Bonjour, J. P., Fleisch, H., and Schenk, R. Increase of whole body calcium and skeletal mass in normal and osteoporotic adult rats treated with parathyroid hormone. Clin Sci 62:389-396; 1982.
8. Hesch, R. D., Hock, J. M., Delling, G., Keck, E., Reeve, J., Canzler, H., Schober, O., and Harms, H. Results of a stimulatory therapy of low bone metabolism osteoporosis with (1-38) hPTH and diphosphonate EHDP. Klin Wochenschrift 66:976-984; 1988.
9. Hesch, R. D., Busch, U., Prokop, M., Delling, G., and Rittinghaus, E. F. Increase of vertebral density by combination therapy with pulsatile 1-38hPTH and sequential addition of calcitonin nasal spray in osteoporotic patients. Calcif Tissue Int 44:176-180; 1989.
10. Hock, J. M., Gera, I., Fonseca, J., and Raisz, L. G. Human parathyroid hormone-(1-34) increases bone mass in ovariectomized and orchidectomized rats. Endocrinology 122:2899-2904; 1988.
11. Kalu, D. N., Pennock, J., Doyle, F. H., and Foster, G. V. Parathyroid hormone and experimental osteosclerosis. Lancet i: 1363-1366; 1970.
12. Kalu, D. N., Echon, R., and Hollis, B. V. Modulation of ovariectomy-related bone loss by parathyroid hormone in rats. Mech Ageing Dev 56:49-62; 1990.
13. Li, Y., Li, X., and Jee, W. S. S. Prolonged bone formation after cessation of human parathyroid hormone treatment in adult rat skeleton [abstract]. J Bone Miner Res 1(Suppl. 1):144; 1986.
14. Li, M., Mosekilde, Li., Søgaard, C. H., and Wronski, T. J. Parathyroid hormone monotherapy and cotherapy with antiresorptive agents restore vertebral bone mass and strength in aged ovariectomized rats. Bone 16: 629-635; 1995.
15. Libermann, U. A., Weiss, S. R., Bröll, J., Minne, H. W., Quan, H., Bell, N. H., Rodriguez-Portales, J., Downs, R. W. Jr., Dequecker, J., Favus, M., Seeman, E., Recker, R. R., Capizzi, T., Santora, A. C., Lombardi, A., Shah, R. V., Hirsch, L. J., and Karpf, D. B. Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. N Engl J Med 333:1437-1443; 1995.
16. Liu, C. C. and Kalu, D. N. Human parathyroid hormone-(1-34) prevents bone loss and augments bone formation in sexually mature ovariectomized rats. J Bone Miner Res 5:973-982; 1990.
17. Liu, C. C., Kalu, D. N., Salerno, E., Echon, R., Mollis, B. W., and Ray, M. Pre-existing bone loss associated with ovariectomy in rats is reversed by parathyroid hormone. J Bone Miner Res 6:1071-1080; 1991.
18. Mosekilde, Li. Assessing bone quality - animal models in preclinical osteoporosis research. Bone 17(Suppl. 1):343S-352S; 1995.
19. Mosekilde, Li., Søgaard, C. H., Danielsen, C. C., Tørring, O., and Nilsson, M. H. L. The anabolic effects of human parathyroid hormone (hPTH) on rat vertebral body mass are also reflected in the quality of bone, assessed by biomechanical testing: A comparison study between hPTH(1-34) and hPTH(1-84). Endocrinology 129:421-428; 1991.
20. Mosekilde, Li., Søgaard, C. H., McOsker, J. E., and Wronski, T. J. PTH has a more pronounced effect on vertebral bone mass and biomechanical competence than antiresorptive agents (estrogen and bisphosphonate)-assessed in sexually mature, ovariectomized rats. Bone 15:401-408; 1994.
21. Mosekilde, Li., Danielsen, C. C., and Gasser, J. A. The effect on vertebral bone mass and strength of long term treatment with antiresorptive agents (estrogen and calcitonin), human parathyroid hormone (1-38), and combination therapy, assessed in aged ovariectomized rats. Endocrinology 134:2126-2134; 1994.
22. Mosekilde, Li., Danielsen, C. C., Søgaard, C. H., McOsker, J. E., and Wronski, T. J. The anabolic effects of parathyroid hormone on cortical bone mass, dimensions and strength-assessed in a sexually mature, ovariectomized rat model. Bone 16:223-230; 1995.
23. Reeve, J., Meunier, P. J., Parsons, J. A., Bernard, M., Buvoet, O. L. M., Courpron, P., Edouard, C., Klenerman, L., Neer, R. M., Renier, J. C., Slovik, O., Vismans, F. J. F. E., and Potts, J. T., Jr. Anabolic effect of human parathyroid hormone fragment on trabecular bone in involutional osteoporosis: A multicenter trial. BMJ 280:1340-1344; 1980.
24. Reeve, J., Davies, U. M., Hesp, R., McNally, E., and Katz, D. Treatment of osteoporosis with human parathyroid peptide and observations on effect of sodium fluoride. BMJ 301:314-318; 1990.
25. Reeve, J., Bradbeer, J. N., Arlot, M., Davies, U. M., Green, J. R., Hampton, L., Edouard, C., Hesp, R., Hulme, P., Ashby, J. P., Zanelli, J. M., and Meunier, P. J. hPTH 1-34 treatment of osteoporosis with added hormone replacement therapy: Biochemical, kinetic and histological responses. Osteopor Int 1:162-170; 1991.
26. Reginster, J.-Y. Management of high turnover osteoporosis with calcitonin. Bone 13(Suppl. 1):S37-S40; 1992.
27. Slovik, D. M., Neer, R. M., and Potts, J. T. Short-term effects of synthetic human parathyroid hormone-(1-34) administration on bone mineral metabolism in osteoporotic patients. J Clin Invest 68:1261-1271; 1981.
28. Slovik, D. M., Rosenthal, D. I., Dopplet, S. H., Potts, J. T. Jr., Daly, M. A., Canbell, J. A., and Neer, R. M. Restoration of spinal bone in osteopenic men by treatment with human parathyroid hormone (1-34) and 1,25 dihydroxyvitamin D. J Bone Miner Res 1:377-381; 1986.
29. Storm, T., Thamsborg, G., Steiniche, T., Genant, H. K., and Sørensen, O. H. Effect of intermittent cyclical etidronate therapy on bone mass and fracture rate in women with postmenopausal osteoporosis. N Engl J Med 322:1265-1271; 1990.
30. Søgaard, C. H., Wronski, T. J., McOsker, J. E., and Mosekilde, Li. The positive effect of parathyroid hormone on femoral neck bone strength in ovariectomized rats is more pronounced than that of estrogen or bisphosphonates. Endocrinology 134:650-657; 1994.
31. Takahashi, H. E., Tanizawa, T., Hori, M., and Uzawa, T. Effect of intermittent administration of human parathyroid hormone (1-34) on experimental osteoporosis in rats induced by ovariectomy. The aged rat model for bone biology studies. Cells Mater (Suppl. 1):113-117; 1991.
32. Tam, C. S., Heersche, J. N. M., Murray, T. M., and Parsons, J. A. Parathyroid hormone stimulates the bone apposition rate independently of its resorptive action: Differential effects of intermittent and continuous administration. Endocrinology 110:506-512; 1982.
33. Thomsen, J. S., Mosekilde, Li., Boyce, R. W., and Mosekilde, E. Stochastic simulation of vertebral trabecular bone remodeling. Bone 15:655-666; 1994.
34. Thomsen, J. S., Barlach, J., and Mosekilde, Li. Determination of connectivity density in human iliac crest biopsies - a new computerized method. Bone 18:459-465; 1996.
35. Watts, N. B., Harris, S. T., Genant, H. K., Wasnich, R. D., Miller, P. D., Jackson, R. D., Licata, A. A., Ross, P., Woodson, G. C., Janover, M. J., Mysiw, J. W., Kohse, L., Rao, M. B., Steiger, P., Richmond, B., and Chesnut, C. H. Intermittent cyclical etidronate treatment of postmenopausal osteoporosis. N Engl J Med 323:73-79; 1990.
36. Wronski, T. J., Schenck, P. A., Cintrón, M., and Walsh, C. C. Effect of body weight on osteopenia in ovariectomized rats. Calcif Tissue Int 40:155-159; 1987.
37. Wronski, T. J., Yen, C.-F., and Dann, L. M. Parathyroid hormone is more effective than estrogen or bisphosphonates for restoration of lost bone mass in ovariectomized rats. Endocrinology 132:823-831; 1993.
38. Wronski, T. J. and Yen, C.-F. Anabolic effects of parathyroid hormone on cortical bone in ovariectomized rats. Bone 15:51-58; 1994.