Effects of clomipramine and desipramine on a C-fiber reflex in rats

European Journal of Pharmacology

Volumn 335, Issue 1, 1997, Pages 1-8

  Mestre, Christine ^a   Hernández, Alejandro ^b   Eschalier, Alain ^a   Pelissier, Teresa ^c  

^a UNIVERSITÉ CLERMONT AUVERGNE   (France)

^b UNIVERSIDAD DE SANTIAGO DE CHILE   (Chile)

^c UNIVERSITY OF CHILE   (Chile)

Author keywords

Analgesia; C fiber reflex; Clomipramine; Desipramine; Pain; Tricyclic antidepressant

Indexed keywords

CLOMIPRAMINE; DESIPRAMINE;

ADRENERGIC SYSTEM; ANESTHESIA; ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; BICEPS BRACHII MUSCLE; CONTROLLED STUDY; DOSE RESPONSE; ELECTROMYOGRAM; ELECTROSTIMULATION; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRATHECAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL; RAT; REFLEX; SEROTONINERGIC SYSTEM; SURAL NERVE;

ANIMALS; ANTIDEPRESSIVE AGENTS, TRICYCLIC; CLOMIPRAMINE; DESIPRAMINE; ELECTRIC STIMULATION; INJECTIONS, INTRAVENTRICULAR; NERVE FIBERS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0343487674     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)01156-4     Document Type: Article

References (65)

1. Aghajanian G.K., Foote W.E., Sheard M.H. Actions of psychotogenic drugs on single midbrain raphe neurons. J. Pharmacol. Exp. Ther. 171:1970;178-187.
2. Ardid D., Eschalier A., Lavarenne J. Evidence for a central but not a peripheral analgesic effect of clomipramine in rats. Pain. 45:1991;95-100.
3. Ardid D., Marty H., Fialip J., Privat A.M., Eschalier A., Lavarenne J. Comparative effects of different uptake inhibitor antidepressants in two pain tests in mice. Fundam. Clin. Pharmacol. 16:1992;75-82.
4. Ardid D., Jourdan D., Mestre C., Villanueva L., Le Bars D., Eschalier A. Involvement of bulbospinal pathways in the antinociceptive effect of clomipramine in the rat. Brain Res. 695:1995;253-256.
5. Beitz A.J. The nuclei of origin of brainstem serotonergic projections to the rodent spinal trigeminal nucleus. Neurosci. Lett. 32:1982;223-228.
6. Botney M., Fields H.L. Amitriptyline potentiates morphine analgesia by a direct action on the central nervous system. Ann. Neurol. 13:1983;160-164.
7. Carlton S.M., Lamotte C.C., Honda C.N., Surmeier D.J., Delanerolle N.C., Willis W.D. Ultrastructural analysis of axosomatic contacts on functionally identified primate spinothalamic tract neurons. J. Comp. Neurol. 281:1989;555-566.
8. Carlton S.M., Honda C.N., Willcockson W.S., Lacrampe M., Zhang D., Denoroy L., Chung J.M., Willis W.D. Descending adrenergic input to the primate spinal cord and its possible role in modulation of spinothalamic cells. Brain Res. 543:1991;77-90.
9. Cesselin, F., Laporte, A.-M., Miquel, M.-C., Bourgoin, S., Hamon, M., 1994. Serotonergic mechanisms of pain control. In: Gebhart, G.F., Hammond, D.L., Jensen, T.S. (Eds.), Progress in Pain Research and Management, vol. 2. IASP Press, Seattle, pp. 669-695.
10. Coquoz D., Porchet H.C., Dayer P. Central analgesic effect of desipramine, fluvoxamine and moclobemide after a single oral dosing. A study in healthy volunteers. Clin. Pharmacol. Ther. 54:1991;339-344.
11. Danysz W., Minor B.G., Post C., Archer T. Chronic treatment with antidepressant drugs and the analgesia induced by 5-methoxy-N,N-dimethyltryptamine: Attenuation by desipramine. Acta Pharmacol. Toxicol. 59:1986;103-112.
12. Davidoff G., Guarracini M., Roth E., Sliwa J., Yarkony G. Trazodone hydrochloride in the treatment of dysesthetic pain in traumatic myelopathy: A randomized, double-blind, placebo-controlled study. Pain. 29:1987;151-161.
13. 2 receptors on rat brainstem neurons. Br. J. Pharmacol. 94:1988;483-491.
14. De Felipe M.C., De Ceballos M.L., Fuentes J.A. Hypoalgesia inducted by antidepressants in mice: A case for opioids and serotonin. Eur. J. Pharmacol. 125:1986;193-199.
15. Dirksen R., Van Diejen D., Van Luijtelaar E.L.J.M., Booij L.H.D.J. Site- and test-dependent antinociceptive efficacy of amitriptyline in rats. Pharmacol. Biochem. Behav. 47:1994;21-22.
16. Eschalier, A., 1990. Antidepressants and Pain Management. In: Besson, J.M. (Ed.), Serotonin and Pain. Excerpta Medica, Amsterdam, pp. 300-325.
17. Eschalier A., Fialip J., Varoquaux O., Makambila M.-C., Marty H., Bastide P. Pharmacokinetic patterns of repeated administration of antidepressants in animals. I. Implications for antinociceptive action of clomipramine. J. Pharm. Exp. Ther. 245:1988;963-968.
18. Eschalier A., Ardid D., Coudoré F. Pharmacological studies of the analgesic effect of antidepressants. Clin. Neuropharmacol. 15 (Suppl. 1):1992;373A-374A.
19. Eschalier A., Mestre C., Dubray C., Ardid D. Why are antidepressants effective as pain relief? CNS Drugs. 2:1994;261-267.
20. Falinower S., Willer J.-C., Junian J.-L., Le Bars D. A C-fibre reflex modulated by heterotopic noxious somatic stimuli in the rat. J. Neurophysiol. 72:1994;194-213.
21. Fasmer O.B., Hunskaar S., Hole K. Antinociceptive effects of serotonergic reuptake inhibitors in mice. Neuropharmacology. 28:1989;1363-1366.
22. Fleetwood-Walker, S.M., 1992. The antinociceptive effects of noradrenergics agonists on the activity of the spinal dorsal horn neurons. In: Besson, J.M., Guilbaud, G. (Eds.), Towards the Use of Noradrenergic Agonists for the Treatment of Pain. Excerpta Medica, Versailles, pp. 181-195.
23. Frank R.G., Kashani J.H., Parker J.C., Beck N.C., Brownlee-Duffeck M., Elliott T.R., Haut A.E., Atwood C., Smith E., Kay D.R. Antidepressant analgesia in rheumatoid arthritis. J. Rheumatol. 15:1988;1632-1638.
24. Guirimand F., Strimbu-Gozariu M., Willer J.-C., Le Bars D. Effects of mu, delta and kappa opioid antagonists on the depression of a C-fiber reflex by intrathecal morphine and DAGO in the rat. J. Pharmacol. Exp. Ther. 269:1994;1007-1020.
25. Guirimand F., Chauvin M., Willer J.-C., Le Bars D. Effects of intravenous morphine and buprenorphine on a C-fibre reflex in the rat. J. Pharmacol. Exp. Ther. 273:1995;830-841.
26. Hammond D.L., Levy R.A., Proufidth H.K. Hypoalgesia following microinjection of noradrenergic antagonists in the nucleus raphe magnus. Pain. 9:1980;85-105.
27. Howe J.R., Wang J.Y., Yaksh T.L. Selective antagonism of the antinociceptive effects of intrathecally applied alpha-adrenergic agonist by intrathecal prazosin and intrathecal yohimbine. J. Pharmacol. Exp. Ther. 224:1983;552-558.
28. Hwang A.S., Wilcox G.L. Analgesic properties of intrathecally administered heterocyclic antidepressants. Pain. 28:1987;343-355.
29. Imahita T., Shimizu T. Imipramine inhibits intrathecal substance P-induced behavior and blocks spinal cord substance P receptors in mice. Brain Res. 581:1992;59-66.
30. Kehl L.J., Wilcox G.L. Antinociceptive effect of tricyclic antidepressants following intrathecal administration. Anesth. Prog. 31:1984;82-84.
31. Larsen J.-J., Arnt J. Spinal 5-HT or NA uptake inhibition potentiates supraspinal morphine antinociception in rats. Acta Pharmacol. Toxicol. 54:1984;72-75.
32. Larsen J.-J., Christensen A.V. Subarachnoidal administration of the 5-HT uptake inhibitor citalopram points to the spinal role of 5-HT in morphine antinociception. Pain. 14:1982;339-346.
33. Le Bars, D., 1988. Serotonin and pain. In: Osborne, N.N., Hamon, M. (Eds.), Neuronal Serotonin. Wiley, Chichester, pp. 171-229.
34. Llewelyn M.B., Azami J., Roberts H.T. The effect of modification of 5-hydroxytryptamine function in nucleus raphe magnus on nociceptive threshold. Brain Res. 306:1984;165-170.
35. Loldrup D., Langemark M., Hansen H.J., Olesen J., Bech P. Clomipramine and mianserin in chronic idiopathic pain syndrome: A placebo controlled study. Psychopharmacology. 99:1989;1-7.
36. Lund A., Tjolsen A., Hole K. The apparent antinociceptive effect of desipramine and zimelidine in the tail flick test in rats is mainly caused by changes in tail skin temperature. Pain. 38:1989;65-69.
37. Lund A., Tjolsen A., Hole K. Antinociceptive effect of intrathecally-administered desipramine and zimelidine in rats. Neuropharmacology. 29:1990;819-823.
38. Magni G. The used of antidepressants in the treatment of chronic pain. Drugs. 42:1991;730-748.
39. Max M.B., Lynch S.A., Muir J., Shoaf S.E., Smoller B., Dubner R. Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy. New Engl. J. Med. 326:1992;1250-1256.
40. Messing R.B., Lytle L.D. Serotonin-containing neurons: Their possible role in pain and analgesia. Pain. 4:1977;1-21.
41. Mestre C., Pelissier T., Fialip J., Wilcox G., Eschalier A. A method to perform direct transcutaneous intrathecal injection in rats. J. Pharmacol. Toxicol. Methods. 32:1994;197-200.
42. Michael-Titus A., Costentin J. Analgesic effects of metapramine and evidence against the involvement of endogenous enkephalins in the analgesia induced by tricyclic antidepressants. Pain. 31:1987;391-400.
43. Onghena P., Van Houdenhove B. Antidepressant-induced analgesia in chronic non-malignant pain: A meta-analysis of 39 placebo-controlled studies. Pain. 49:1992;205-220.
44. Pellegrino, L.J., Cushman, A.J., 1967. A Stereotaxic Atlas of the Rat Brain. Appleton-Century-Crofts, New York.
45. Proudfit, H.B., 1988. Pharmacologic evidence for the modulation of nociception by noradrenergic neurons. In: Fields, H.L., Besson, J.-M. (Eds.), Progress in Brain Research, vol. 77. Elsevier Science Publishers B.V., Amsterdam, pp. 357-370.
46. Rigal F., Eschalier A., Devoize J.-L., Pechadre J.-C. Activities of five antidepressants in behavioral pain test in rats. Life Sci. 32:1983;2965-2971.
47. Reichenberg K., Gaillard-Plaza G., Montastruc J.L. Influence of naloxone on the antinociceptive effects of some antidepressant drugs. Arch. Int. Pharmacodyn. Ther. 275:1985;78-85.
48. Sacerdote P., Brini A., Mantegazza P., Panerai A.E. A role for serotonin and betaendorphin in the analgesia induced by some tricyclic antidepressant drugs. Pharmacol. Biochem. Behav. 26:1987;153-158.
49. Sagen J., Proudfit H.K. Evidence for pain modulation by pre- and postsynaptic noradrenergic receptors in the medulla oblongata. Brain Res. 331:1985;285-293.
50. Sagen J., Proudfit H.K. Alterations in nociception following lesions of the A5 catecholamine nucleus. Brain Res. 370:1986;93-100.
51. Sierralta F., Pinardi G., Miranda H.F. Effect of p-chlorophenylalanine and α-methyltyrosine on the antinociceptive effect of antidepressant drugs. Pharmacol. Toxicol. 77:1995;276-280.
52. Sierralta F., Pinardi G., Mendez M., Miranda H.F. Interaction of opioid with antidepressant-induced antinociception. Psychopharmacology. 122:1995;374-378.
53. Sindrup S.H. Antidepressants in the treatment of diabetic neuropathy symptoms. Pharmacodynamic, pharmacokinetic, and pharmacogenetic aspects. Dan. Med. Bull. 41:1994;66-78.
54. Sindrup S.H., Gram L.F., Brosen K., Eshoy O., Mogensen E.F. The selective serotonin reuptake inhibitor paroxetine is effective in the treatment of diabetic neuropathy symptoms. Pain. 42:1990;135-144.
55. Sindrup S.H., Bjerre U., Dejgaard A., Brosen K., Aaes-Jorgensen T., Gram L.F. The selective serotonin reuptake inhibitor citalopram relieves the symptoms of diabetic neuropathy. Clin. Pharmacol. Ther. 52:1992;547-552.
56. Sjaastad O. So-called 'tension headache' the response to a 5HT uptake inhibitor: Femoxetine. Cephalgia. 3:1983;53-60.
57. Sorkin, L.S., McAdoo, D.J., Willis, W.D., 1990. Release of serotonin following brainstem stimulation: correlation with inhibition of nociceptive dorsal horn neurons. In: Besson, J.M. (Ed.), Serotonin and Pain. Excerpta Medica, Amsterdam, pp. 105-116.
58. Sorkin L.S., McAdoo D.J., Willis W.D. Stimulation in the ventral posterior lateral nucleus of the primate thalamus leads to release of serotonin in the lumbar spinal cord. Brain Res. 581:1992;307-310.
59. Spiegel K., Kalb R., Pasternak G.W. Analgesic activity of tricyclic antidepressants. Ann. Neurol. 13:1983;462-465.
60. Strimbu-Gozariu M., Guirimand F., Willer J.-C., Le Bars D. A sensitive test for studying effects of opioids on a C-fibre reflex elicited by a wide range of stimulus intensities in the rat. Eur. J. Pharmacol. 237:1993;197-205.
61. Taiwo Y.O., Fabian A., Pazoles C.J., Fields H.L. Potentiation of morphine antinociception by monoamine reuptake inhibitors in the rat spinal cord. Pain. 21:1985;329-337.
62. Takahashi R.N., Paz M.M. Influence of naloxone on analgesic effects of antidepressants in mice. Braz. J. Med. Biol. Res. 20:1987;607-610.
63. Takano Y., Yaksh T.L. Characterization of the pharmacology of intrathecally administered alpha-2 agonists and antagonists in rats. J. Pharmacol. Exp. Ther. 261:1992;764-772.
64. Tura B., Tura S.M. The analgesic effect of tricyclic antidepressants. Brain Res. 518:1990;19-22.
65. Ventafridda V., Bianchi M., Ripamonti C., Sacerdote P., De Conno F., Zecca E., Panerai A.E. Studies on the effects of antidepressant drugs on the antinociceptive action of morphine and on plasma morphine in rat and man. Pain. 43:1990;155-162.