LDL receptor activity in human leukocyte subtypes: Regulation by insulin

Clinical Biochemistry

Volumn 30, Issue 7, 1997, Pages 531-538

  Nägele, Herbert ^a   Gebhardt, Angelika ^a   Niendorf, Axel ^a   Kroschinski, Jörg ^a   Zeller, Wolfgang ^b  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b UNIVERSITY OF HAMBURG   (Germany)

Author keywords

Fluorescence; Insulin; LDL receptor; Leukocytes; Monoclonal antibodies

Indexed keywords

INSULIN; LOW DENSITY LIPOPROTEIN RECEPTOR;

ARTICLE; ATHEROGENESIS; B LYMPHOCYTE; CELL MEMBRANE TRANSPORT; HORMONAL REGULATION; HUMAN; HUMAN CELL; LIPID TRANSPORT; LYMPHOCYTE SUBPOPULATION; PRIORITY JOURNAL; PROTEIN LIPID INTERACTION; RECEPTOR DENSITY; T LYMPHOCYTE;

BLOOD DONORS; FLOW CYTOMETRY; HUMANS; INSULIN; LEUKOCYTES; LEUKOCYTES, MONONUCLEAR; LIPOPROTEINS, LDL; RECEPTORS, LDL; REFERENCE VALUES; REPRODUCIBILITY OF RESULTS;

EID: 0343487588     PISSN: 00099120     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-9120(97)00051-9     Document Type: Article

References (63)

1. Brown MS, Goldstein JL. A receptor mediated pathway for cholesterol homeostasis. Science. 232:1986;34-47.
2. Anderson RG, Goldstein JL, Brown MS. Localization of low density lipoprotein receptors on plasma membrane of normal human fibroblasts and their absence in cells from a familial hypercholesterolemia homozygote. Proc Natl Acad Sci USA. 73:1976;2434-2438.
3. Brown MS, Goldstein JL. Lipoprotein receptors in the liver. Control signals for plasma cholesterol traffic. J Clin Invest. 72:1983;743-747.
4. Semenkovich CF, Ostlund RE Jr. The low density lipoprotein receptor on human peripheral blood monocytes and lymphocytes visualization by ligand blotting and immunoblotting techniques . J Clin Endocrinol Metab. 62:1986;1279-1287.
5. Aviram M, Brook JG, Tatarsky I, Levy Y, Carter A. Increased low-density lipoprotein levels after splenectomy a role for the spleen in cholesterol metabolism in myeloproliferative disorders . Am J Med Sci. 291:1986;25-28.
6. Fogelman AM, Van Lenten BJ, Warden C, Haberland ME, Edwards PA. Macrophage lipoprotein receptors. J Cell Sci Suppl. 9:1988;135-149.
7. Swaminathan N, Venkataraman K, Gadgil U, Margolin K. Possible mechanism of interleukin-2-induced decline of serum cholesterol during adoptive cellular immunotherapy in cancer patients. Biochem Med Metab Biol. 49:1993;212-216.
8. Cuthbert JA, Lipsky PE. Immunoregulation by low density lipoproteins in man. Inhibition of mitogen-induced T lymphocyte proliferation by interference with transferrin metabolism. J Clin Invest. 73:1984;992-1003.
9. Cuthbert JA, Lipsky PE. Low-density lipoprotein (LDL) and lymphocyte responses direct suppression by native LDL and indirect inhibition from zinc chelation by contaminating EDTA . Biochim Biophys Acta. 876:1986;210-219.
10. Gerrity RG. The role of the monocyte in atherogenesis. I. Transition of blood-borne monocytes into foam cells in fatty lesions II. Migration of foam cells from atherosclerotic plaques. Am J Pathol. 103:1981;181-200.
11. Aqel NM, Ball RY, Waldmann H, Mitchinson MJ. Monocytic origin of foam cells in human atherosclerotic plaques. Atherosclerosis. 53:1984;265-271.
12. Pedréno J, Sanchez JL, Zambón D, Ros E. In-vitro effect of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors on non-hepatic LDL receptor activity evidence of lack of stimulatory effect of pravastatin . Coronary Art Dis. 5:1994;971-977.
13. Stulnig TM, Klocker H, Harwood HJ Jr, Juergens G, Schoenitzer D, Jarosch E, Huber LA, Amberger A, Wick G. In vivo LDL receptor and HMG-CoA reductase regulation in human lymphocytes and its alterations during aging. Arterioscler Thromb Vasc Biol. 15:1995;872-878.
14. Brown MS, Goldstein JL. Regulation of the activity of the low density lipoprotein receptor in human fibroblasts. Cell. 6:1975;307-316.
15. Smith JR, Osborne TF, Goldstein JL, Brown MS. Identification of nucleotides responsible for enhancer activity of sterol regulatory element in low density lipoprotein receptor gene. J Biol Chem. 265:1990;2306-2310.
16. Wade DP, Knight BL, Soutar AK. Hormonal regulation of low-density lipoprotein (LDL) receptor activity in human hepatoma Hep G2 cells. Insulin increases LDL receptor activity and diminishes its suppression by exogenous LDL. Eur J Biochem. 174:1988;213-218.
17. Brown MS, Kovanen P, Goldstein JL. Regulation of plasma cholesterol by lipoprotein receptors. Science. 212:1981;628-635.
18. Krone W, Nägele H, Behnke B, Greten H. Opposite effects of insulin and catecholamines on LDL-receptor activity in human mononuclear leukocytes. Diabetes. 37:1988;1386-1391.
19. Chait A, Bierman EL, Albers JJ. Regulatory role of triiodothyronine in the degradation of low density lipoprotein by cultured human skin fibroblasts. J Clin Endocrinol Metab. 48:1979;887-889.
20. Chait A, Bierman EL, Albers JJ. Regulatory role of insulin in the degradation of low density lipoprotein by cultured human skin fibroblasts. Biochim Biophys Acta. 529:1978;292-299.
21. Mazzone T, Foster D, Chait A. In vivo stimulation of low-density lipoprotein degradation by insulin. Diabetes. 33:1984;333-338.
22. Sato Y, Shiraishi S, Oshida Y, Ishiguro T, Sakamoto N. Experimental atherosclerosis-like lesions induced by hyperinsulinism in Wistar rats. Diabetes. 38:1989;91-96.
23. Stout RW. Insulin and atheroma - an update. Lancet 1987; 1: 8541, 1077-9.
24. Beisiegel U, Schneider W, Goldstein JL, Anderson R, Brown MS. Monoclonal antibodies to the low density lipoprotein receptor as probes for study of receptor-mediated endocytosis and the genetics of familial hypercholesterolemia. J Biol Chem. 256:1981;11923-11931.
25. Gherardi E, Bowyer DE, Fitzsimmons C, Le Cras T, Hutchings A, Butcher G. Probing of the expression of the low-density lipoprotein receptor in vivo using an anti-receptor monoclonal antibody. Biochem J. 280:1991;1-7.
26. Pedréno J, de Castellarnau C, Cullare C, Sanchez J, Gomez-Gerique J, Ordonez-Llanos J, Gonzalez-Sastre F. LDL binding sites on platelets differ from the "classical" receptor of nucleated cells. Arterioscler Thromb. 12:1992;1353-1362.
27. Barak LS, Webb WW. Fluorescent low density lipoprotein for observation of dynamics of individual receptor complexes in cultured human fibroblasts. J Cell Biol. 90:1981;595-604.
28. Sakai H, Kaneshige H, Endoh M. Determination of LDL receptors on cultured lymphocytes using fluorescein-labeled LDL. Am J Clin Pathol. 78:1982;58-62.
29. Berg KA, Berry ML, Sapareto SA, Petty HR. Fluorescence studies of macrophage recognition and endocytosis of native and acetylated low-density lipoprotein. Biochim Biophys Acta. 887:1986;304-314.
30. Ranganathan S, Hattori H, Kashyap ML. A rapid flow cytometric assay for low-density lipoprotein receptors in human peripheral blood mononuclear cells. J Lab Clin Med. 125:1995;479-486.
31. Yen CF, Kalunta CI, Chen FS, Kaptein JS, Lin CK, Lad PM. Flow cytometric evaluation of LDL receptors using Dil-LDL uptake and its application to B and T lymphocytic cell lines. J Immunol Methods. 177:1994;55-67.
32. Traill KN, Boeck G, Winter U, Hilchenbach M, Juergens G, Wick G. Simple method for comparing large numbers of flow cytometry histograms exemplified by analysis of the CD4 (T4) antigen and LDL receptor on human peripheral blood lymphocytes. J Histochem Cytochem. 34:1986;1217-1221.
33. Via PV, Smith LC. Fluorescence labeling of lipoproteins. Met Enzymol. 129:1986;848-857.
34. Bohn B. Flow Cytometry A novel approach for the quantitative analysis of receptor-ligand interactions on surfaces of living cells . Moll Cell Endocrinol. 20:1980;1-15.
35. Böyum A. Isolation of mononuclear cells and granulocytes from human blood. Scand J Clin Lab Invest Suppl. 97:1968;77-89.
36. Havel RJ, Eder HA, Bragdon JH. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J Clin Invest. 34:1955;1345-1353.
37. Hinton RH, Al-Tamer Y, Mallinson A, Marks V. The use of density gradient centrifugation for the separation of serum lipoproteins. Clin Chim Acta. 53:1974;355-360.
38. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the folin phenol reagent. J Biol Chem. 193:1951;265-275.
39. Stöhr M, Vogt-Schaden M. A new dual staining technique for simultaneous flow cytometric DNA analysis of living and dead cells. Flow Cytometry. IV:1980;96-99.
40. Goldstein JL, Brown MS. Binding and degradation of low density lipoprotein by cultured human fibroblasts. Comparison of cells from a normal subject and from a patient with homozygous familial hypercholesterolemia. J Biol Chem. 249:1974;5153-5162.
41. Anderson RGW, Brown MS, Goldstein JL. Role of the coated endocytic vesicle in the uptake of receptor-bound low density lipoprotein in human fibroblasts. Cell. 10:1977;351-364.
42. Pittman R, Attie A, Carew T, Steinberg D. Tissue sites of degradation of low density lipoproteins application of a method for determining the fate of plasma proteins . Proc Natl Acad Sci USA. 76:1979;5345-5349.
43. Krieger M, Brown MS, Faust J, Goldstein JL. Replacement of endogenous cholesteryl esters of low density lipoprotein with exogenous cholesteryl linoleate. Reconstitution of a biologically active lipoprotein. J Biol Chem. 253:1979;4093-4101.
44. Handley DA, Arbeeny CM, Witte LD, Chien S. Colloidal gold-low density lipoprotein conjugates as membrane receptor probes. Proc Natl Acad Sci USA. 78:1981;368-371.
45. Beisiegel U, Kita T, Anderson RGW, Schneider WJ, Brown MS, Goldstein JL. Immunologic cross-reactivity of the low density lipoprotein receptor from bovine adrenal cortex, human fibroblasts, canine liver and adrenal gland and rat liver. J Biol Chem. 256:1981;4071-4078.
46. Daniel T, Schneider WJ, Goldstein JL, Brown MS. Visualization of lipoprotein receptors by ligand blotting. J Biol Chem. 258:1983;4606-4611.
47. Huettinger M, Corbett JR, Schneider WJ, Willerson JT, Brown MS, Goldstein JL. Imaging of hepatic low density lipoprotein receptors by radionuclide scintiscanning in vivo. Proc Natl Acad Sci USA. 81:1984;7599-7603.
48. Lees R, Garabedian H, Lees A, Schumacher J, Miller A. Technetium-99m low density lipoproteins preparation and biodistribution . J Nucl Med. 26:1985;1056-1062.
49. Wade DP, Knight BL, Soutar A. Detection of the low-density-lipoprotein receptor with biotin-low-density lipoprotein. A rapid new method for ligand blotting. Biochem J. 229:1985;785-790.
50. Preobrazhensky SN, Ivanov V, Fuki I, Tsibulsky V, Kameneva A. Enzyme-linked immunoreceptor assay of low-density-lipoprotein receptors. Analyt Biochem. 149:1985;269-274.
51. Preobrazhensky SN, Tsibulsky VP, Fuki IV, Ivanov VO, Repin VS, Smirnov VN. Enzyme immunoassay of the receptors for modified low density lipoprotein. Analyt Biochem. 154:1986;382-387.
52. Roach PD, Zollinger M, Noel SP. Detection of the low density lipoprotein (LDL) receptor on nitrocellulose paper with colloidal gold-LDL conjugates. J Lip Res. 28:1987;1515-1521.
53. Rayner HC, Horsburgh T, Brown SL, Lavender FL, Winder AF, Walls J. Receptor-mediated endocytosis of low-density lipoprotein by cultured human glomerular cells. Nephron. 55:1990;292-299.
54. Ho YK, Brown MS, Bilheimer DW, Goldstein JL. Regulation of low density lipoprotein receptor activity in freshly isolated human lymphocytes. J Clin Invest. 58:1976;1465-1474.
55. Cuthbert JA, Lipsky PE. Assessment of functional low-density lipoprotein receptor activity on lymphocytes of normal subjects and patients with familial hypercholesterolemia. Trans Assoc Am Physicians. 101:1988;1-11.
56. Schmitz G, Bruening T, Kovacs E, Barlage S. Fluorescence flow cytometry of human leukocytes in the detection of LDL receptor defects in the differential diagnosis of hypercholesterolemia. Arterioscler Thromb. 13:1993;1053-1065.
57. Hayashi K, Nakashima K, Saeki M, Kurushima H, Kurokawa J, Kuga Y, Nomura S, Ohkura Y, Ohtani H, Tanaka K. Identification of a functional receptor differing from the LDL receptor that catabolizes chylomicron remnant in Hep G2 cells. Atherosclerosis. 104:1993;105-115.
58. Glaeser C, Handschug K, Ludvik S, Schell U, Hehr A, Kuechenhoff A, Robenek H. The importance of the alpha 2MR/LRP for human genetics. Investigations of the receptor expression in different human blood cells. Ann N Y Acad Sci. 737:1994;447-450.
59. Suresh S, Warty V, Virji M, Sanghvi A. Effect of insulin on low density lipoprotein metabolism in human lymphocytes in vitro. Biochem J. 233:1986;565-570.
60. Traill KN, Huber LA, Wick G, Juergens G. Lipoprotein interactions with T cells an update . Immunology Today. 11:1990;411-417.
61. Endemann G, Stanton LW, Madden KS, Bryant CM, White RT, Protter AA. CD36 is a receptor for oxidized low density lipoprotein. J Biol Chem. 268:1993;11811-11816.
62. Lestavel-Delattre S, Martin-Nizard F, Clavey V, et al. Low-density lipoprotein for delivery of an acrylophenone antineoplastic molecule into malignant cells. Canc Res. 52:1992;3629-3635.
63. Juompan L, Puel J, Fournie GJ, Benoist H. Study of LDL and acetylated LDL endocytosis by mononuclear cells in HIV infection. Biochim Biophys Acta. 1272:1995;21-28.