In vitro degradation of serum albumin microcapsules: Effect of process variables

International Journal of Pharmaceutics

Volumn 152, Issue 2, 1997, Pages 145-151

  Andry, M C ^a   Levy M C ^a  

^a UNIVERSITÉ DE REIMS CHAMPAGNE ARDENNE   (France)

Author keywords

Human serum albumin; Interfacial cross linking; Microcapsule; Peptsin; Terephthaloyl chloride; Trypsin

Indexed keywords

HUMAN SERUM ALBUMIN; PEPSIN A; TRYPSIN;

ARTICLE; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG MANUFACTURE; DRUG STABILITY; IN VITRO STUDY; MICROCAPSULE; MICROSCOPY; PH; PRIORITY JOURNAL; REACTION TIME; SOLUBILIZATION;

EID: 0343471999     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(97)04923-5     Document Type: Article

References (15)

1. Andry, M.-C., Edwards-Lévy, F. and Lévy, M.-C., Free amino group content of serum albumin microcapsules: III. A study at low pH values. Int. J. Pharm., 128 (1996) 197-202.
2. Desnuelle, P., Trypsin. In Boyer, P.D., Hardy, H. and Myrback, K. (Eds), The Enzymes, Vol. 4, Academic Press, New York, 1960, pp. 63-92.
3. Dixon, M. and Webb, E.C., Enzyme specificity. In Dixon, M. and E.C. (Eds), Enzymes, Longmans, London, 1965, pp. 199-258.
4. Edwards-Lévy, F., Andry, M.-C. and Lévy, M.-C., Determination of free amino group content of serum albumin microcapsules using trinitrobenzenesulfonic acid: effect of variations in polycondensation pH. Int. J. Pharm., 96 (1993) 85-90.
5. Edwards-Lévy, F., Andry, M.-C. and Lévy, M.-C., Determination of free amino group content of serum albumin microcapsules: II. Effect of variations in reaction time and in terephthaloylchloride concentration. Int. J. Pharm., 103 (1994) 253-257.
6. Gupta, P.K. and Hung, C.T., Review. Albumin microspheres I: physico-chemical characteristics. J. Microencapsulation, 6 (1989a) 427-462.
7. Gupta, P.K. and Hung, C.T., Review. Albumin microspheres II: applications in drug delivery. J. Microencapsulation, 6 (1989b) 463-472.
8. Hettler, D., Andry, M.-C. and Lévy, M.-C., Polyhydroxamic microcapsules prepared from proteins: a novel type of chelating microcapsules. J. Microencapsulation, 11 (1994) 213-224.
9. Lee, T.K., Sokoloski, T.D. and Royer, G.P., Serum albumin beads: an injectable, biodegradable system for the sustained release of drugs. Science, 213, (1981) 233-235.
10. Lévy, M.-C., Andry, M.-C., Terrey, V. and Pierron, C., An evaluation of gelatin microcapsules prepared using an interfacial cross-linking process. Life Sci. Adv., 9, (1990) 219-227.
11. Lévy, M.-C., Lefèbvre, S., Rahmouni, M., Andry, M.-C. and Manfait, M., Fourier transform infrared spectroscopic studies of human serum albumin microcapsules prepared by interfacial cross-linking with terephthaloylchloride: influence of polycondensation pH on spectra and relation with microcapsule morphology and size. J. Pharm. Sci., 80 (1991) 578-585.
12. Lévy, M.-C., Lefèbvre, S., Andry, M.-C., Rahmouni, M. and Manfait, M., Fourier transform infrared spectroscopic studies of human serum albumin microcapsules. 2. Influence of reaction time on spectra and correlation with microcapsule morphology and size. J. Pharm. Sci., 83 (1994) 419-422.
13. Lévy, M.-C., Lefèbvre, S., Andry, M.-C. and Manfait, M., Fourier transform infrared spectroscopic studies of human serum albumin microcapsules. 3. Influence of terephthaloyl chloride concentration on spectra and correlation with microcapsule morphology and size. J. Pharm. Sci., 84 (1995) 161-165.
14. Magee, G.A., Halbert, G.H. and Wilmott, N., Effect of process variables on the in vitro degradation of protein microspheres. J. Controlled Release, 37 (1995) 11-19.
15. Willmott, N., Cummings, J., Stuart, J.F.B, and Florence, A.T., Adriamycin-loaded albumin microspheres: in vivo distribution and drug release rate in the rat. Biopharm. Drug Dispos., 6 (1985) 91-104.