Delayed decrease of excitatory amino acid neurotransmitters in parietotemporal cortex and hippocampus after complete cerebral ischemia in aged rats

Archives of Gerontology and Geriatrics

Volumn 24, Issue 1, 1997, Pages 23-33

  M̈ldner, Albrecht ^a   Hoyer, Siegfried ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Age; Amino acid neurotransmitters; Brain; Ischemia; Postischemic recirculation

Indexed keywords

4 AMINOBUTYRIC ACID; AMINO ACID RECEPTOR AFFECTING AGENT; ASPARTIC ACID; EXCITATORY AMINO ACID; GLUTAMIC ACID; GLYCINE; NEUROTRANSMITTER;

AGED; ANIMAL EXPERIMENT; ARTICLE; BRAIN ISCHEMIA; BRAIN METABOLISM; ENERGY METABOLISM; HIPPOCAMPUS; MALE; NERVE CELL LESION; NONHUMAN; PARIETAL LOBE; PRIORITY JOURNAL; RAT; TEMPORAL CORTEX;

EID: 0343471486     PISSN: 01674943     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4943(96)00724-8     Document Type: Article

References (26)

1. Andine, P., Orwar, O., Jacobson, I., Sandberg, M. and Hagberg, H. (1991): Changes in extracellular amino acids and spontaneous neuronal activity during ischemia and extended reflow in the CA1 of the rat hippocampus. J. Neurochem., 57, 222-229.
2. Beneviste, H., Drejer, J., Schousboe, A. and Diemer, N. H. (1984): Elevation of the extracellular concentration of glutamate and aspartate in rat hippocampus during transient cerbral ischemia monitored by intracerebral microdialysis. J. Neurochem., 43, 1369-1374.
3. Cobo, M., Exposito, I., Porras, A. and Mora, F. (1992): Release of amino acid neurotransmitters in different cortical areas of conscious adult and aged rats. Neurobiol. Aging, 13, 705-709.
4. Dawson, R. Jr., Wallace, D. R. and Meldrum, M. J. (1989): Endogenous glutamate release from frontal cortex of adult and aged rats. Neurobiol. Aging, 10, 665-668.
5. Degrell, I., Krier, C. and Hoyer, S. (1983): Carbohydrate and energy metabolism of the aging rat brain in severe arterial hypoxemia. In: Brain Aging: Neuropathology and Neuropharmacology (Aging, Vol. 21), pp. 289-300. Editors: J. Cervos-Navarro and H.J. Sarkander. Raven, New York.
6. Erecinska, M., Nelson, D., Wilson, D.F. and Silver, I.A. (1984): Neurotransmitter amino acids in the CNS.I. Regional changes in amino acid levels in rat brain during ischemia and reperfusion. Brain Res., 304, 9-22.
7. Globus, M.Y.-T., Busto, R., Dietrich, W.D., Martinez, E., Valdes, I. and Ginsberg, M.D. (1988): Effect of ischemia on the in vivo release of striatal dopamine, glutamate and gamma-aminobutyric acid studied by intracerebral microdialysis. J. Neurochem., 60, 66-71.
8. Globus, M.Y.-T., Ginsberg, M.D. and Busto, R. (1991): Excitotoxic index - a biochemical marker of selective vulnerability. Neurosci. Lett., 127, 39-42.
9. Hagberg, H., Lehmann, A., Sandberg, M., Nystr̈m, B., Jacobson, I. and Hamberger, A. (1985): Ischemia-induced shift of inhibitory and excitatory amino acids from intra-to extracellular compartments. J. Cereb. Blood Flow Metab., 5, 413-419.
10. Hatakeyama, Y., Matsumoto, M., Brengman, J.M. and Yanagihara, T. (1988): Immunohistochemical investigation of ischemic and postischemic damage after bilateral carotid occlusion in gerbils. Stroke, 19, 1526-1534.
11. Hauptmann, M., Nelson, D., Wilson, D.F. and Erecinska, M. (1984): Neurotransmitter acids in the CNS. II. Some changes in amino acid levels in rat brain synaptosomes during and after in vitro anoxia and simulated ischemia. Brain Res., 304, 23-35.
12. Hollander, C.F., van Zwieten, M.J. and Zurcher, C. (1983): The aged animal. In: Aging of the Brain, pp. 187-196. Editors: W.H. Gispen and J. Traber. Eisevier, Amsterdam.
13. Hoyer, S. (1985): The effect of age on glucose and energy metabolism in brain cortex of rats. Arch. Gerontol. Geriatr., 4, 193-203.
14. Hoyer, S. (1988): Glucose and related brain metabolism in normal aging. Age, 11, 150-156.
15. Hoyer, S. and Krier, C. (1986): Ischemia and the aging brain. Studies on glucose and energy metabolism in rat cerebral cortex. Neurobiol. Aging, 7, 23-29.
16. Hoyer, S. and Betz, K. (1988): Abnormalities in glucose and energy metabolism are more severe in the hippocampus than in the cerebral cortex in postischemic recovery in aged rats. Neurosci. Lett., 94, 167-172.
17. Johnson, J.W. and Ascher, P. (1987): Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature, 325, 529-531.
18. Lerma, J., Zukin, R.S. and Bennett, M.V.L. (1990): Glycine decreases desensitization of N-methyl-D-as-partate (NMDA) receptors expressed in Xenopus oocytes and is required for NMDA responses. Proc. Natl. Acad. Sci. USA, 87, 2354-2358.
19. Martinez, M., Hernanz, A., Ferrandiz, M.L., De Juan, E., Sevila, I., Martinez, N. and Miquel, J. (1995): Glucose deprivation increases aspartic acid release from synaptosomes of aged mice. Brain Res., 673, 149-152.
20. Matsumoto, K., Lo, E.H., Pierce, A.R., Halpern, E.F. and Newcomb, R. (1996): Secondary elevation of extracellular neurotransmitter amino acids in the reperfusion phase following focal cerebral ischemia. J. Cereb. Blood Flow Metab., 16, 114-124.
21. Mitani, A., Andou, Y., Masuda, S. and Katakoa, K. (1991): Transient forbrain ischemia of three-minute duration consistently induces severe neuronal damage in field CA1 of the hippocampus in the normothermic gerbil. Neurosci. Lett., 131, 171-174.
22. Palmer, A.M., Robichaud, P.J. and Reiter, C.T. (1994): The release and uptake of excitatory amino acids in rat brain: effect of aging and oxidative stress. Neurobiol. Aging, 15, 103-111.
23. Rothman, S.M. and Olney, J.W. (1987): Excitotoxicity and the NMDA receptor. Trends Neurosci., 10, 299-302.
24. Taguchi, J., Graf, R., Rosner, G., Matsumoto, K. and Heiss, W.D. (1993): Evolution of neuronal death in penumbra may be related to glutamate increase in cat focal ischemia. J. Cereb. Blood Flow Metab., 13, S757.
25. Tapia, R. (1975): Biochemical pharmacology of GABA in CNS. In: Handbook of Pharmacology, Vol. 4, Amino Acid Neurotransmitters, pp. 1-58. Editors: L.L. Iversen, S.D. Iversen and S.H. Snyder. Plenum Press, New York.
26. Tomimoto, H., Wahita, H., Akiguchi, I., Nakamura, S. and Kimura, J. (1994): Temporal profiles of accumulation of amyloid beta/A4 protein precursor in the gerbil after graded ischemic stress. J. Cereb. Blood Flow Metab., 14, 565-573.