Ovarian resistance to luteinizing hormone: A novel cause of amenorrhea and infertility

Fertility and Sterility

Volumn 67, Issue 2, 1997, Pages 394-397

  Arnhold, Ivo Jorge Prado ^a,b   Carvalho, Filomena Marino ^a,b   Latronico, Ana Claudia ^a,b   Chrousos, George Panagiotis ^a,b   Batista, Marcelo Cidade ^a,b   Mendonça, Berenice Bilharinho ^a,b  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Amenorrhea; gonadotropins; infertility; luteinizing hormone receptor; ovarian physiology; polycystic ovaries

Indexed keywords

CHORIONIC GONADOTROPIN; DEXAMETHASONE; FOLLITROPIN; LUTEINIZING HORMONE;

ADULT; AMENORRHEA; ARTICLE; CASE REPORT; CORPUS LUTEUM FUNCTION; FEMALE; FEMALE INFERTILITY; FEMINIZATION; GENE SEQUENCE; HISTOLOGY; HORMONE RESISTANCE; HUMAN; KARYOTYPING; OVARY FOLLICLE; OVARY FOLLICLE DEVELOPMENT; OVULATION; PATHOGENESIS; PRIORITY JOURNAL; PSEUDOHERMAPHRODITISM;

EID: 0343471460     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0015-0282(97)81929-2     Document Type: Article

References (6)

1. Kremer N, Kraaij R, Toledo SPA, Post M, Fridman JB, Hayashida CY, et al. Male pseudohermaphroditism due to a homozygous missence mutation of the luteinizing hormone receptor gene. Nature Genet 1995;9:160-4.
2. Latronico AC, Anasti J, Arnhold IJP, Rapaport R, Mendonça BB, Bloise W, et al. Testicular and ovarian resistance to luteinizing hormone caused by homozygous inactivating mutations of the luteinizing hormone receptor gene. N Engl J Med 1996;334:507-12.
3. Saldanha PH, Arnhold IJP, Mendonça BB, Bloise W, Toledo SPA. A clinico-genetic investigation of Leydig cell hypoplasia. Am J Med Genet 1987;23:337-44.
4. Magoffin DA, Gelety TJ, Magarelli PC. Follicular development: the role of LH. In: Filicori M, Flamigni C, editors. Ovulation induction: basic science and clinical advances. Amsterdam: Elsevier Science B.V., 1994:25-36.
5. McNatty KP, Makris A, DeGrazia C, Osathanondh R, Ryan KJ. The production of progesterone, androgens, and estrogens by granulosa cells, thecal tissue, and stromal tissue from human ovaries in vitro. J Clin Endocrinol Metab 1979;49:687-99.
6. School DC, Coelingh-Bennink HJT, Mannaerts BMJL, Lamberts SWJ, Bouchard P, Fauser BCJM. Human recombinant follicle-stimulating hormone induces growth of preovulatory follicles without concomitant increase in androgen and estrogen biosynthesis in a woman with isolated gonadotropin deficiency. J Clin Endocrinol Metab 1992;74:1471-3.