Synthesis of enantiomerically pure forms of trans-3-phenylglycidic acid.

Tetrahedron Letters

Volumn 38, Issue 5, 1997, Pages 861-864

  Plucińska, Krystyna ^a   Kasprzykowski, Franciszek ^a   Kozian, Elzbieta ^a  

^a UNIVERSITY OF GDA SK   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

3 PHENYLGLYCIDIC ACID; PROPIONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG PURITY; DRUG SYNTHESIS; ENANTIOMER; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; REACTION ANALYSIS;

EID: 0343417027     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(96)02426-4     Document Type: Article

References (19)

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18. The optically pure trans-3-phenylglycidc acids can be stored as crystals for several weeks in a refrigerator (<0°C), in dry conditions.HPLC test on the stability of the acids in benzene solution at RT, indicates c.a. 20% of decomposition after 1hr. The complete deterioration of the sample is observed within minutes, at 50°C.
19. Therefore, the oxirane ring may serve as a competitive electrophilic center causing by-product formation.