Further evidence for the increased power of LOD scores compared with nonparametric methods

American Journal of Human Genetics

Volumn 64, Issue 1, 1999, Pages 281-289

  Durner, Martina ^a   Vieland, Veronica J ^c   Greenberg, David A ^a,b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b MOUNT SINAI MEDICAL CENTER   (United States)

^c UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; DOMINANT INHERITANCE; GENE LOCUS; GENETIC ANALYSIS; GENETIC LINKAGE; HUMAN; PRIORITY JOURNAL; RECESSIVE INHERITANCE; SEGREGATION ANALYSIS;

EID: 0343399663     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/302181     Document Type: Article

References (26)

1. Blackwelder WC, Elston RC (1985) A comparison of sib-pair linkage tests for disease susceptibility loci. Genet Epidemiol 2:85-97
2. Cavalli-Sforza LL, Bodmer WF (1971) The genetics of human populations. WH Freeman, San Francisco, pp 310-313
3. Clerget-Darpoux F, Bonaiti-Pellie C, Hoches J (1986) Effects of misspecifying genetic parameters in lod score analysis. Biometrics 42:393-399
4. Davis S, Weeks DE (1997) Comparison of nonparametric statistics for detection of linkage in nuclear families: single-marker evaluation. Am J Hum Genet 61:1431-1444
5. Dizier M-H, Babron M-C, Clerget-Darpoux (1996) Conclusions of LOD- score analysis for family data generated under two-locus models. Am J Hum Genet 58:1338-1346
6. Dizier M-H, Bonaïti-Pellié C, Clerget-Darpoux F (1993) Conclusions of segregation analysis for family data generated under two-locus models. Am J Hum Genet 53:1338-1346
7. Durner M, Greenberg DA (1992) Effect of heterogeneity and assumed mode of inheritance on lod scores. Am J Med Genet 42:271-275
8. Durner M, Greenberg DA, Hodge SE (1992) Inter- and intrafamilial heterogeneity: effective sampling strategies and comparison of analysis methods. Am J Hum Genet 51:859-870
9. Goldin LR (1994) Genetic heterogeneity and other complex models: a problem for linkage detection. In: Gershon ES, Cloninger CR (eds) Genetic approaches to mental disorders. American Psychiatric Press, Washington, DC, pp 77-87
10. Goldin LR, Weeks DE (1993) Two-locus models of disease: comparison of likelihood and nonparametric linkage methods. Am J Hum Genet 53:908-915
11. Greenberg DA (1986) The effect of proband designation on segregation analysis. Am J Hum Genet 39:329-339
12. _ (1990) Linkage analysis assuming a single-locus mode of inheritance for traits determined by two loci: inferring mode of inheritance and estimating penetrance. Genet Epidemiol 7:467-479
13. Greenberg DA, Abreu P, Hodge SE (1998) The power to detect linkage in complex disease by means of simple LOD-score analyses. Am J Hum Genet 63:870-879
14. Greenberg DA, Hodge SE (1989) Linkage analysis under "random" and "genetic" reduced penetrance. Genet Epidemiol 6:259-264
15. Greenberg DA, Hodge SE, Vieland VJ, Spence MA (1996) Affecteds-only linkage methods are not a panacea. Am J Hum Genet 58:892-895
16. Hodge SE (1998) Exact ELODs and exact power for affected sib pairs analyzed for linkage under simple right and wrong models. Am J Med Genet 81:66-72
17. Hodge SE, Abreu PC, Greenberg DA (1997) Magnitude of type I error when single-locus linkage analysis is maximized over models: a simulation study. Am J Hum Genet 60:217-227
18. Hodge SE, Elston RC (1994) Lods, wrods, and mods: the interpretation of lod scores calculated under different models. Genet Epidemiol 11:329-342
19. Kidd K (1997) Can we find genes for schizophrenia? Am J Med Genet 74:104-111
20. Knapp M, Seuchter SA, Baur MP (1994) Linkage analysis in nuclear families. II. Relationship between affected sib-pair tests and lod score analysis. Hum Hered 44:44-51
21. Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES (1996) Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet 58:1347-63
22. Lalouel JM, Yee S (1980) POINTER: a computer program for complex segregation analysis with pointers. Tech rep, Population Genetics Laboratory, University of Hawaii, Honolulu
23. Lathrop GM, Ott J (1990) Analysis of complex diseases under oligogenic models and intrafamilial heterogeneity by the LINKAGE programs. Am J Hum Genet Suppl 47:A188
24. Ott J (1974) Estimation of the recombination fractions in human pedigrees. Am J Hum Genet 26:588-597
25. Vieland VJ, Greenberg DA, Hodge SE (1992) Adequacy of single-locus approximations for linkage analyses of oligogenic traits. Genet Epidemiol 9:45-59
26. Vieland VJ, Greenberg DA, Hodge SE (1993) Adequacy of single-locus approximations for linkage analyses of oligogenic traits: extension to multigenerational pedigree structures. Hum Hered 43:329-336