Functional, biochemical, and molecular investigations of renal kallikrein-kinin system in diabetic rats

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 277, Issue 6 46-6, 1999, Pages

  Tschope C ^a   Reinecke, A ^b   Seidl, U ^c   Yu, M ^b   Gavriluk, V ^b   Riester, U ^c   Gohlke, P ^b   Graf, K ^e   Bader, M ^d   Hilgenfeldt, U ^c   Pesquero, J B ^d,f   Ritz, E ^c   Unger, T ^b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF KIEL   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^e HUMBOLDT UNIVERSITY   (Germany)

^f FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Angiotensin converting enzyme; Bradykinin B2 receptor; Diabetic nephropathy; Kininogen; Neutral endopeptidase 24.11; Streptozotocin

Indexed keywords

BRADYKININ; BRADYKININ B2 RECEPTOR; DIPEPTIDYL CARBOXYPEPTIDASE; KININASE; KININOGEN; MEMBRANE METALLOENDOPEPTIDASE; PREKALLIKREIN; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC NEPHROPATHY; ENZYME ACTIVITY; GLOMERULUS FILTRATION RATE; HYPERGLYCEMIA; KALLIKREIN KININ SYSTEM; MALE; NONHUMAN; POLYURIA; PRIORITY JOURNAL; PROTEINURIA; RAT;

EID: 0343340435     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1999.277.6.h2333     Document Type: Article

References (53)

1. Allen, T. J., Z. Cao, S. Youssef, L. Hulthen, and M. E. Cooper. Role of angiotensin II and bradykinin in experimental diabetic nephropathy. Functional and structural studies. Diabetes 46: 1612-1618, 1997.
2. Amundsen, E., J. Putter, P. Friberger, M. Knös, M. Larsbraten, and G. Claesen. Methods for the determination of glandular kallikrein by means of a chromogenic tripeptide substrate. Adv. Exp. Med. Biol. 120: 83-95, 1979.
3. Anderson, S., F. F. Jung, and J. R. Ingelfinger. Renal renin-angiotensin system in diabetes: functional, immunohistochemical, and molecular biological correlations. Am. J. Physiol. 265 (Renal Fluid Electrolyte Physiol. 34): F477-F486, 1993.
4. Bank, N., M. A. G. Lahorra, H. S. Aynedjian, and D. Schlondorff. Vasoregulatory hormones and the hyperfiltration of diabetes. Am. J. Physiol. 254 (Renal Fluid Electrolyte Physiol. 23): F202-F209, 1988.
5. Carone, F. A., T. N. Pullman, S. Oparil, and S. Nakamuras. Micropuncture evidence of rapid hydrolysis of bradykinin by rat proximal tubule. Am. J. Physiol. 230: 1420-1424, 1976.
6. Craven, G., P. Friberger, M. Knös, and E. Eriksson. Methods for determination of prekallikrein in plasma, glandular kallikrein, and urokinase. Haemostasis 7: 76-78, 1978.
7. Correa-Rotter, R., T. H. Hostetter, and M. E. Rosenberg. Renin and angiotensinogen gene expression in experimental diabetes mellitus. Kidney Int. 41: 796-804, 1992.
8. Craven, P. A., and F. R. DeRubertis. Role for local prostaglandin and thromboxane production in the regulation of glomerular filtration rate in the rat with streptozocin-induced diabetes. J. Lab. Clin. Med. 113: 674-681, 1989.
9. Craven, P. A., R. K. Studer, and F. R. DeRubertis. Impaired nitric oxide-dependent cyclic guanosine monophosphate generation in glomeruli from diabetic rats. Evidence for protein kinase C-mediated suppression of the cholinergic response. J. Clin. Invest. 93: 311-320, 1994.
10. Flammenbaum, W., J. Gagnon, and P. Ramwell. Bradykinin-induced renal hemodynamic alterations: renin and prostaglandin relationships. Am. J. Physiol. 237 (Renal Fluid Electrolyte Physiol. 6): F433-F440, 1979.
11. Harvey, N. J., W. A. Edmundson, A. A. Jaffa, L. L. Martin, and R. K. Mayfield. Renal excretion of kallikrein and eicosanoids in patients with Type 1 (insulin-dependent) diabetes mellitus. Relationship to glomerular and tubular function. Diabetologia 35: 857-862, 1992.
12. Hilgenfeldt, U., R. Linke, U. Riester, W. König, and G. Breipohl. Strategy of measuring bradykinin and kallidin and their concentration in plasma and urine. Anal. Biochem. 228: 35-41, 1995.
13. Hostetter, T. H., J. L. Troy, and B. M. Brenner. Glomerular hemodynamics in experimental diabetes mellitus. Kidney Int. 19: 410-415, 1981.
14. Ichikawa, I., M. L. Purkerson, S. Klahr, J. L. Troy, M. Martinez-Maldonado, and B. M. Brenner. Mechanism of reduced glomerular filtration rate in chronic malnutrition. J. Clin. Invest. 65: 982-988, 1980.
15. Jaffa, A. A., D. H. Miller, G. S. Bailey, J. Chao, H. S. Margolius, and R. K. Mayfield. Abnormal regulation of renal kallikrein in experimental diabetes. J. Clin. Invest. 80: 1651-1659, 1987.
16. Jaffa, A. A., J. N. Harvey, S. E. Sutherland, H. S. Margolius, and R. K. Mayfield. Renal kallikrein responses to dietary protein: a possible mediator of hyperfiltration. Kidney Int. 36: 1003-1010, 1989.
17. Jaffa, A. A., K. X. Chai, J. Chao, L. Chao, and R. K. Mayfield. Effects of diabetes and insulin on expression of kallikrein and renin genes in the kidney. Kidney Int. 41: 789-795, 1992.
18. Jaffa, A. A., P. F. Rust, and R. K. Mayfield. Kinin, a mediator of diabetes-induced glomerular hyperfiltration. Diabetes 44: 156-160, 1995.
19. Jaffa, A. A., R. H. Silva, B. Kim, and R. K. Mayfield. Modulation of renal kallikrein production dietary protein in streptozotocin-induced diabetic rats. J. Am. Soc. Nephrol. 7: 721-727, 1996
20. Jensen, P. K., J. S. Christiansen, K. Steven, and H.-H. Parving. Strict metabolic control and renal function in streptozotocin diabetic rat. Kidney Int. 31: 47-51, 1986.
21. Kauker, M. K., J. T. Crofton, L. Share, and A. Nasjletti. Role of vasopressin in regulation of renal kinin excretion in Long-Evans and diabetes insipidus rats. J. Clin. Invest. 73: 824-831, 1984.
22. Kitagawa, H., N. Kitamura, H. Hayashida, T. Miyata, and S. Nakanashi. Differing expression patterns and evolution of the rat kininogen gene family. J. Biol. Chem. 262: 2190-2198, 1987.
23. Komers, R., and M. E. Cooper. Acute renal hemodynamic effects of ACE inhibition in diabetic hyperfiltration: role of kinins. Am. J. Physiol. 268 (Renal Fluid Electrolyte Physiol. 37): F588-F594, 1995.
24. Kühnle, H. F., P. Linzmeier, and L. Doerge. Determination of glomerular filtration rate in rats. In: Experimental and Genetic Rat Models of Chronic Renal Failure, edited by N. Gretz and M. Strauch. Basel, Switzerland: Karger, 1989, p. 331-336.
25. Levinsky, N. G. The renal kallikrein-kinin system. Circ. Res. 44: 441-451, 1979.
26. Lorens-Cortes C., B. Giros, and J. C. Schwartz. A novel potential metallopeptidase derived from the enkephalinase gene by alternative splicing. J. Neurochem. 55: 2146-2148, 1990.
27. Maeda, S., R. Kikkawa, M. Haneda, M. Togawa, D. Koya, N. Horide, N. Kajiwara, T. Uzu, and Y. Shigeta, Reduced activity of renal angiotensin-converting enzyme in streptozotocin-induced diabetic rats. J. Diabetes Complications 5: 225-229, 1991.
28. Majima, M., and M. Katori. Approaches to the development of novel antihypertensive drugs: crucial role of the renal kallikrein-kinin system. Trends Pharmacol. Sci. 16: 239-246, 1995.
29. Margolius, H. S. Tissue kallikreins and kinins: regulation and roles in hypertensive and diabetic diseases. Annu. Rev. Pharmacol. Toxicol. 29: 343-336, 1989.
30. Mayfield, R. K., H. S. Margolius, G. S. Bailey, D. H. Miller, D. A. Sens, J. Squires, and D. H. Namm Urinary and renal tissue kallikrein in the streptozocin-diabetic rat. Diabetes 34: 22-28, 1985.
31. Nasjletti, A., J. Colina-Chourie, and J. C. McGiff. Disappearance of bradykinin in the renal circulation of dogs. Effects of kininase inhibition. Circ. Res. 37: 162-165, 1978.
32. O'Donnell, M. P., B. L. Kasiske, and W. F. Keane. Glomerular hemodynamic and structural alterations in experimental diabetes. FASEB J. 2: 2339-2347, 1988.
33. Quilley, J., and J. C. McGiff. Influence of insulin on urinary eicosanoid excretion in rats with experimental diabetes mellitus. J. Pharmacol. Exp. Ther. 238: 606-611, 1986.
34. Reis, M. L., R. Paschoalato, and C. H. Serra. Kininogen changes in the alloxan-diabetic rat. Agents Actions Suppl. 36: 223-29, 1992.
35. Remuzzi, A., N. Perico, C. S. Amuchastegui, B. Malanchini, M. Mazerska, C. Battaglia, T. Bertani, and G. Remuzzi. Short- and long-term effect of angiotensin II receptor blockade in rats with experimental diabetes. J. Am. Soc. Nephrol 4: 40-49, 1993.
36. Scicli, G. A., S. F. Rabito, and O. A. Carretero. Effects of pH and amiloride on the intrarenal formation of kinins. Am. J. Physiol. 245 (Renal Fluid Electrolyte Physiol. 14): F198-F203, 1983.
37. Scicli, A. G., and O. A. Carretero. Renal kallikrein-kinin system. Kidney Int. 29: 120-30, 1986.
38. Siragy, H. M., A. A. Jaffa, H. S. Margolius, and R. M. Carey. Renin-angiotensin system modulates renal bradykinin production. Am. J. Physiol. 271 (Regulatory Integrative Comp. Physiol. 40): R1090-R1097, 1996.
39. Skidgel, R. A. Bradykinin-degrading enzymes: structure, function, distribution, and potential roles in cardiovascular pharmacology. J. Cardiovasc. Pharmacol. 20, Suppl. 9: S4-S9, 1992.
40. Stauss, B., K. Itoi, H. Stauss, and T. Unger. A novel inexpensive computer system to record and analyze hemodynamic data in conscious animals. Eur. J. Pharmacol. 183: 863-864, 1990.
41. Tschöpe, C., V. Gavriluk, A. Reinecke, U. Seidl, U. Riester, U. Hilgenfeldt, E. Ritz, and T. Unger. Bradykinin excretion is increased in severely hyperglycemic streptozotocin-diabetic rats. Immunopharmacology 33: 344-348, 1996.
42. Tschöpe, C., P. Gohlke, Y.-Z. Zhu, W. Linz, B. Schölkens, and T. Unger. Antihypertensive and cardioprotective effects after angiotensin-converting enzyme inhibition: role of kinins. J Card. Fail. 3: 133-148, 1997.
43. Tschöpe, C., M. Yu, A. Reinecke, T. Csikos, U. Hilgenfeldt, J. B. Pesquero, E. Ritz, and T. Unger. Renal expression of two rat kallikrein genes under diabetic conditions. J. Hypertens. 15: 1711-1714, 1997.
44. Uehara, S., S. Isogowa, W. Sakamoto, and A. Hirayama. Kallikrein-kinin system in diabetic patients. Arzneimittelforschung 38: 721-723, 1988.
45. Unger, T., B. Schüll, W. Rascher, E. R. Lang, and D. Ganten. Selective activation of the converting enzyme inhibitor MK 421 and comparison of its active diacid form with captopril in different tissues of the rat. Biochem. Pharmacol. 31: 3063-3070, 1982.
46. Ura, N., O. A. Carretero, and E. G. Erdös. Role of renal endopeptidase 24.11 in kinin metabolism in vitro and in vivo. Kidney Int. 32: 507-513, 1987
47. Vio, C. P., L. Churchill, S. F. Rabito, A. Terragno, O. A. Carretero, and N. A. Terragno. Renal kallikrein in venous effluent of filtering and non-filtering isolated kidneys. Adv. Exp. Med. Biol. 156: 897-907, 1983.
48. Vio, C. P. Renal kallikrein. In: Pathophysiology, Diagnosis and Management, edited by J. H. Laragh and B. M. Brenner. New York: Raven, 1990, p. 819-829.
49. Vora, J. P., T. T. Oyama, M. M. Thompson, and S. Anderson. Interactions of the kallikrein-kinin and renin-angiotensin systems in experimental diabetes. Diabetes 46: 107-112, 1997.
50. Wagner, J., G. Stein, J. Man, and E. Ritz. Influence of dietary factors on the renal renin-angiotensin system. Klin. Wochenschr. 69, Suppl. XXIX: 35-38, 1992.
51. Wang, C., C. Chao, L.-M. Chen, L. Chao, and J. Chao. High-salt diet upregulates kininogen and downregulates kallikrein expression in Dahl-SS and SHR rats. Am. J. Physiol. 271 (Renal Fluid Electrolyte Physiol. 40): F824-F830, 1996.
52. Yamasu, A., S. Oh-ishi, I. Hayashi, K. Hayashi, M. Hayashi, K. Yamaki, T. Nakano, and N. Sunahara. Differentiation of kinin fractions in ureter and bladder urine of normal and kininogen-deficient rats. J. Pharmacobiodyn. 12: 287-292, 1989.
53. Ziyadeh, F. N., and S. Goldfarb. The renal tubulointerstitium in diabetes mellitus. Kidney Int. 39: 464-475, 1991.