Beta-blockers inhibit the modification of low-density lipoproteins by sodium hypochlorite in vitro

Chemistry and Physics of Lipids

Volumn 85, Issue 1, 1997, Pages 13-21

  Seifert, T ^a   Zschornig O ^a   Arnhold, J ^a   Arnold, K ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Beta blockers; J774 macrophages; Laser electrophoresis; Low density lipoproteins (LDL); Sodium hypochlorite; Zeta potential

Indexed keywords

ACEBUTOLOL; ALPRENOLOL; ATENOLOL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CHOLESTEROL ESTER; DICLOFENAC; HYPOCHLORITE SODIUM; LOW DENSITY LIPOPROTEIN; NONSTEROID ANTIINFLAMMATORY AGENT; OXPRENOLOL; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG PROTEIN BINDING; ELECTROPHORESIS; HUMAN; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN MODIFICATION; SPECTROSCOPY;

ACEBUTOLOL; ADRENERGIC BETA-ANTAGONISTS; ALPRENOLOL; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARTERIOSCLEROSIS; ATENOLOL; BEPRIDIL; CHEMISTRY; CHOLESTEROL ESTERS; DICLOFENAC; FREE RADICALS; HUMANS; LIPOPROTEINS, LDL; MACROPHAGES; MOLECULAR STRUCTURE; OXPRENOLOL; PARTICLE SIZE; PICRATES; SODIUM HYPOCHLORITE; SPECTRUM ANALYSIS; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 0343196704     PISSN: 00093084     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-3084(96)02637-0     Document Type: Article

References (38)

1. Arnhold, J., Wiegel, D., Richter, O., Hammerschmidt, S., Arnold, K. and Krumbiegel, M. (1991) Modification of low density lipoproteins by sodium hypochlorite. Biomed. Biochim. Acta 50, 967-973.
2. Arnhold, J., Panasenko, O.M., Schiller, J., Vladimirov Yu. A. and Arnold, K. (1995) The action of hypochlorous acid on phosphatidylcholine liposomes in dependence on the content of double bonds. Chem. Phys. Lipids 78, 55-64.
3. Bowry, V.B. and Stocker, R. (1993) Tocopherol-mediated peroxidation. The prooxidant effect of vitamin E on the radical-initiated oxidation of human low-density lipoprotein. J. Am. Chem. Soc. 115, 6029-6045.
4. Chait, A., Gilmore, M. and Kawamura, M. (1994) Inhibition of low density lipoprotein oxidation in vitro by the 6- and 7-hydroxy-metabolites of doxazosin, an alpha-1-adrenergic antihypertensive agent. Am. J. Hypertens. 7, 159-167.
5. Cookson, F.B. (1971) The origin of foam cells in atherosclerosis. Br. J. Exp. Pathol. 52, 62-67.
6. Croft, K.D., Dimmit, S.B., Moulton, C. and Beilin, L.J. (1992) Low density lipoprotein composition and oxidizability in coronary disease - apparent favourable effects of beta blockers. Atherosclerosis 97, 123-130.
7. Daugherty, A., Dunn, J.L. and Heinecke, J.W. (1994) Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesions. J. Clin. Invest. 94, 437-444.
8. Esterbauer, H., Striegl, G., Puhl, H. and Rotheneder, M. (1988) Continuous monitoring of in vitro oxidation of human low density lipoprotein. Free Radic. Res. Commun. 6, 67-75.
9. Esterbauer, H., Dieber-Rotheneder, M., Waeg, G., Striegl, G. and Jürgens, G. (1990) Biochemical, structural and functional properties of oxidized low-density lipoproteins. Chem. Res. Toxicol. 3, 77-92.
10. Esterbauer, H., Gebicki, J., Puhl, H. and Jürgens, G. (1992) The role of lipid peroxidation and antioxidants in oxidative modification of LDL. Free Radic. Biol. Med. 13, 341-390.
11. Gieseg, S.P., Reibnegger, G., Wachter, H. and Esterbauer, H. (1995) 7,8-Dihydroneopterin inhibits low density lipoprotein oxidation in vitro. Evidence that this macrophage secreted pteridine is an antioxidant. Free Radic. Res. 23, 123-136.
12. Giessauf, A., Steiner, E. and Esterbauer, H. (1995) Early destruction of tryptophan residues of apolipoprotein B is a vitamin E independent process during copper mediated oxidation of LDL. Biochim. Biophys. Acta 1256, 221-232.
13. Havel, R.J., Eder, H.A. and Brangdon, J.H. (1955) The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J. Clin. Invest. 34, 1345-1353.
14. Hazell, L.J. and Stocker, R. (1993) Oxidation of low density lipoprotein with hypochlorite causes transformation of the lipoprotein into a high uptake form for macrophages. Biochem. J. 290, 165-172.
15. Hazell, L.J., van den Berg, J.J.M. and Stocker, R. (1994) Oxidation of low-density lipoprotein by hypochlorite causes aggregation that is mediated by modification of lysine residues rather than lipid oxidation. Biochem. J. 302, 297-304.
16. Hiramatsu, M., Liu, J., Edamatsu, R., Ohba, S., Kadowaki, D. and Mori, A. (1994) Probucol scavenged 1,1-diphenyl-2-picrylhydrazyl radicals and inhibited formation of thiobarbituric acid reactive substances. Free Radic. Biol. Med. 16, 201-206.
17. Kalyanaram, B., Darley-Usmar, V., Struck, A., Hogg, N. and Parthasarathy, S. (1995) Role of apolipoprotein B-derived radical and alpha-tocopheroxyl radical in peroxidase-dependent oxidation of low density lipoprotein. J. Lipid Res. 36, 1037-1045.
18. Kowanko, I.C., Bates, E.J. and Ferrante, A. (1989) Mechanisms of human neutrophil mediated cartilage damage in vitro: the role of lysosomal enzymes, hydrogen peroxide and hypochlorous acid. Immunol. Cell. Biol. 67, 321-329.
19. Krieger, M. and Herz, J. (1994) Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor-related protein (LRP). Annu. Rev. Biochem. 63, 601-637.
20. Lehtonen, A. (1986) The effects of adrenoceptor and adrenergic blocking drugs on plasma lipoproteins, in: Pharmacological Control of Hyperlipidaemia, J.R. Prous Science Publishers, S.A., New York, pp. 377-387.
21. Maeba, R., Shimasaki, H. and Ueta, N. (1994) Conformational changes in oxidized LDL recognized by mouse peritoneal macrophages. Biochim. Biophys. Acta 1215, 79-86.
22. Mazière, C., Auclair, M. and Mazière, J.-C. (1992) Lipophilic β-blockers inhibit monocyte and endothelial cell-mediated modification of low density lipoproteins. Biochim. Biophys. Acta 1126, 314-318.
23. Middeke, M., Richter, W.O., Schwandt, P., Beck, B. and Holzgreve, H. (1990) Normalization of lipid metabolism after withdrawal from antihypertensive long-term therapy with beta blockers and diuretics. Arteriosclerosis 10, 145-147.
24. Napoli, C., Ambrosio, G., Chiariello, P., Palumbo, G. and Chiariello, M. (1994) Protezione da parte dei bloccanti della perossidazione delle lipoprotein umane a bassa densita indotta dai radicali liberi dell' ossigenio. G. Ital. Cardiol. 24, 361-366 (in Italian).
25. Nenseter, M.S., Halvorsen, B., Rosvold, O., Rustan, A.C. and Drevon, C.A. (1995) Paracetamol inhibits copper ion-induced azo compound-initiated and mononuclear cell mediated oxidative modification of LDL. Arterioscler. Thromb. Vase. Biol. 15, 1338-1344.
26. O'Connell, A.M., Gieseg, S.P. and Stanley, K.K. (1994) Hypochlorite oxidation causes crosslinking of Lp(a). Biochim. Biophys. Acta 1225, 180-186.
27. -'. Free Radic. Biol. Med. 16, 143-148.
28. Parthasarathy, S., Young, S.G., Witztum, J.L., Pittmann, R.C. and Steinberg, D. (1986) Probucol inhibits oxidative modification of low density lipoprotein. J. Clin. Invest. 77, 641-644.
29. Santanam, V. and Parthasarathy, S. (1995) Paradoxical actions of antioxidants in the oxidation of low density lipoprotein by peroxidases. J. Clin. Invest. 95, 2594-2600.
30. Sassa, H., Kogure, K., Takaishi, Y. and Terada, H. (1994) Structural basis of the potent antiperoxidation activity of the triterpene celastrol in mitochondria: effect of negative membrane surface charge on lipid peroxidation. Free Radic. Biol. Med. 17, 201-207.
31. Selley, M.L., Czeti, A.L., McGuiness, J.A. and Ardlie, N.G. (1994) Dipyridamole inhibits the oxidative modification of low density lipoprotein. Atherosclerosis 111, 91-97.
32. Steinberg, D., Parthasarathy, S., Carew, T.E., Khoo, J.C. and Witztum, J.L. (1989) Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. N. Engl. J. Med. 320, 915-924.
33. Uchiyama, M. and Mihara, M. (1978) Determination of malondialdehyde precursor in tissues by thiobarbituric acid test. Anal. Biochem. 86, 279-286.
34. Vallner, J.J. and Chen, L. (1977) β-Lipoproteins: possible plasma transport proteins for basic drugs. J. Pharm. Sci. 66, 420-421.
35. Williams, P., Ongsakul, M., Proudfoot, J., Croft, K. and Beilin, L. (1995) Mangostin inhibits the oxidative modification of human low density lipoprotein. Free Radic. Res. 23, 175-184.
36. Winkler, L., Schlag, B., Rüger, H.-J. and Dargel, R. (1986) Eine Methodenvariante zur immunturbidimetrischen Bestimmung von Apolipoprotein A-I und B im Serum. Z. Med. Lab. Diagn. 27, 372-376 (in German).
37. Winterbourn, C.C. (1985) Comparative reactivities of various biological compounds with myeloperoxidase-hydrogen peroxide-chloride, and similarity of the oxidant to hypochlorite. Biochim. Biophys. Acta 840, 204-210.
38. Zschörnig, O., Wiegel, D. and Arnold, K. (1987) Interaction of beta-adrenergic blocking agents with human low density lipoproteins detected by EPR. Mol. Cryst. Liq. Cryst. 152, 363-367.