Ionizing radiation-induced death in bovine lens epithelial cells: Mechanisms and influence of irradiation dose rate

International Journal of Cancer

Volumn 90, Issue 3, 2000, Pages 138-144

  Belkacémi, Yazid ^a,b   Piel, Gaëlic ^c   Rat, Patrice ^a   Julia, Fréderic ^b   Touboul, Emmanuel ^b   Housset, Martin ^b   Warnet, Jean Michel ^a  

^a CENTRE HOSPITALIER NATIONAL D OPHTALMOLOGIE DES QUINZE VINGTS   (France)

^b HÔPITAL TENON   (France)

^c HÔPITAL PAUL BROUSSE   (France)

Author keywords

Apoptosis; Cataract; Dose rate; Fluorimetric methods; Lens cells; Radiation

Indexed keywords

ANIMAL CELL; ANIMAL MODEL; APOPTOSIS; ARTICLE; CATARACTOGENESIS; CELL VIABILITY; DNA MODIFICATION; DOSE RESPONSE; FLUOROMETRY; LENS EPITHELIUM; NONHUMAN; PRIORITY JOURNAL; RADIATION CATARACT; RADIATION DOSE;

ANIMALS; APOPTOSIS; BENZIMIDAZOLES; CATARACT; CATTLE; CELLS, CULTURED; EPITHELIAL CELLS; FLUOROMETRY; LENS, CRYSTALLINE; RADIATION DOSAGE;

EID: 0343167936     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0215(20000620)90:3<138::AID-IJC3>3.0.CO;2-Q     Document Type: Article

References (24)

1. Ozsahin M, Belkacémi Y, Pène F, Dominique C, Schwartz LH, Uzal C, Lefkopoulos D, Gindrey-Vie B, Vitu L, Touboul E, Schlienger M, Laugier A. Total body irradiation and cataract incidence: a randomized comparison of two instantaneous dose rates. Int J Radiat Oncol Biol Phys 1994;28:343-347.
2. Belkacémi Y, Ozsahin M, Pène F. Rio B, Laporte J-P, Leblond V, Touboul E, Schlienger M, Gorin NC, Laugier A. Cataractogenesis after total body irradiation. Int J Radiat Oncol Biol Phys 1996;35:53-60.
3. Belkacémi Y, Labopin M, Vernant JP, Prentice HG, Tichelli A, Schattenberg A, Boogaerts MA, Ernst P, Delia Volpe A, Goldstone AH, Jouet JP, Verdonck LF, Locasciulli A, Rio B, Ozsahin M, Gorin NC. Cataracts after total body irradiation and bone marrow transplantation in patients with acute leukemia in complete remission: a study of the European Group for Blood and Marrow Transplantation. Int J Radiat Oncol Biol Phys 1998;41:659-668.
4. Chalupecky H. Ueber die Wirkung der Röntgenstrahlen auf das Auge und die Haut. Zentralbl. Augenheilk 1897;21:234.
5. Aufderheide E, Rink H, Heiber L, Kraft G, Heavy ion effects on cellular DNA: strand break induction and repair in cultured diploid lens epithelial cells. Int J Radiat Oncol Biol Relat Stud Phys Chem Med I987;51: 779-790.
6. Baumstark-Khan C, Aufderheide E, Rink H. X-ray induced DNA strand break induction and rejoining in cultured bovine lens epithelial cells. Ophthalmic Res 1992;24:220-227.
7. Li WC, Spector A. Lens epithelial cell apoptosis is an early event in the development of UVB-induced cataract. Free Radic Biol Med 1996;20:301-311.
8. 60CO teletherapy unit for total body irradiation. Int J Radiat Oncol Biol Phys 1995;33: 951-957.
9. Balls M, Fentem JH. The use of basal cytotoxicity and target organ toxicity tests in hazard identification and risk assessment. Alternatives To Laboratory Animals 1992;20:368-388.
10. Rat P, Christen M-O, Thevenin M, Warnet J-M, Adolphe M. Cold light fluorimetry, a microtitration technology for cell culture. Applications to biothiols: cytoprotective effects evaluation. Methods Enzymol 1995; 252:331-340.
11. Rat P, Osseni R, Christen M-O, Thevenin M, Warnet J-M. Adolphe M. Microtitration fluorimetric assays on living cells: new tools for screening in cell pharmacotoxicology. In: van Zutphen LFM, Balls M, editors. Animal alternatives, welfare and ethics. Amsterdam: Elsevier; 1997. p 813-823.
12. Borenfreund E, Puerner JA. A simple quantitative procedure using monolayer cultures for cytotoxicity assays (HTD/NR-90). J Tissue Cult Methods 1984;9:7-9.
13. Rat P, Korwin-Zmijowska C, Warnet J-M, Adolphe M. New in vitro fluorimetric microtitration assays for toxicological screening of drugs. Cell Biol Toxicol 1994; 10:329-337.
14. Hall EJ. Radiation cataractogenesis. In: Hall EJ, editor. Radiobiology for the radiologist. Philadelphia: Lippincott: 1994. p 378-384.
15. Fife K, Milan S, Westbrook K, Powels R, Tait D. Risk factors for requiring cataract surgery following total body irradiation. Radiother Oncol 1994;33:93-98.
16. Lett JT, Cox AB, Lee AC. Some perspectives on cataractogenesis from heavy charged particles. Radiat Res 1985;8:S201-S207.
17. Lui J, Hales AM, Chamberlin CG, McAvoy JW. Induction of cataract-like changes in rat lens epithelial explants by transforming growth factor beta. Invest Ophthalmol Vis Sci 1994;35:388-401.
18. Verrelle P, Bourhis J. Modulation of cellular response to ionizing radiation: towards new molecular targets. Cancer Radiother 1997; 1:484-493.
19. Balls M. Clothier RH. Comments on the scientific validation and regulatory acceptance of in vitro toxicity tets. Toxicol In Vitro 1991;5:535-538.
20. Kleiman NJ, Wang RR, Spector A. Ultraviolet light induced DNA damage and repair in bovine lens epithelial cells. Curr Eye Res 1990;9:1185-1193.
21. Ishizaki Y, Voyvodic JT, Burne JF, Raff MC. Control of lens epithelial survival. J Cell Biol 1993;121:899-908.
22. Garadi R, Giblin FJ, Reddy VN. Disulfide-linked membrane protein in x-ray induced cataract. Ophthalmic Res 1987;19:141-149.
23. Hightower KR, Giblin FJ, Reddy VN. Changes in the distribution of lens calcium during development of x-ray cataract. Invest Ophthalmol Vis Sci 1983;24:1118-1193.
24. Harding JJ. Experimental opacification of the lens in vivo and in vitro. In: Harding J, editor. Cataract: biochemestry. epidemiology and pharmacology. London: Chapman and Hall; 1991. p 147-150.